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β‑Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences
β‑Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences
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β‑Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences

Hansen, Jacob C ; Bjørn-Yoshimoto, Walden E ; Bisballe, Niels ; Nielsen, Birgitte ; Jensen, Anders A ; Bunch, Lennart

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.8771-8786 [Periódico revisado por pares]

United States: American Chemical Society

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2
4-Hydroxy-1,2,5-oxadiazol-3-yl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Molecular Pharmacological Characterization at Ionotropic Glutamate Receptors of Compounds Related to Glutamate and Its Homologues
4-Hydroxy-1,2,5-oxadiazol-3-yl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Molecular Pharmacological Characterization at Ionotropic Glutamate Receptors of Compounds Related to Glutamate and Its Homologues
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4-Hydroxy-1,2,5-oxadiazol-3-yl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Molecular Pharmacological Characterization at Ionotropic Glutamate Receptors of Compounds Related to Glutamate and Its Homologues

Lolli, Marco L ; Giordano, Cecilia ; Pickering, Darryl S ; Rolando, Barbara ; Hansen, Kasper B ; Foti, Antonio ; Contreras-Sanz, Alberto ; Amir, Ahmad ; Fruttero, Roberta ; Gasco, Alberto ; Nielsen, Birgitte ; Johansen, Tommy N

Journal of medicinal chemistry, 2010-05, Vol.53 (10), p.4110-4118 [Periódico revisado por pares]

United States: American Chemical Society

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3
Synthesis and pharmacological evaluation of conformationally constrained glutamic acid higher homologues
Synthesis and pharmacological evaluation of conformationally constrained glutamic acid higher homologues
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Synthesis and pharmacological evaluation of conformationally constrained glutamic acid higher homologues

Tamborini, Lucia ; Cullia, Gregorio ; Nielsen, Birgitte ; De Micheli, Carlo ; Conti, Paola ; Pinto, Andrea

Bioorganic & medicinal chemistry, 2016-11, Vol.24 (22), p.5741-5747 [Periódico revisado por pares]

England

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4
Binding Mode of an α‑Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1
Binding Mode of an α‑Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1
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Binding Mode of an α‑Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1

Demmer, Charles S ; Møller, Charlotte ; Brown, Patricia M. G. E ; Han, Liwei ; Pickering, Darryl S ; Nielsen, Birgitte ; Bowie, Derek ; Frydenvang, Karla ; Kastrup, Jette S ; Bunch, Lennart

ACS chemical neuroscience, 2015-06, Vol.6 (6), p.845-854 [Periódico revisado por pares]

United States: American Chemical Society

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5
The Glutamate Receptor GluR5 Agonist (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization
The Glutamate Receptor GluR5 Agonist (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization
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The Glutamate Receptor GluR5 Agonist (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization

CLAUSEN, Rasmus P ; NAUR, Peter ; NIELSEN, Birgitte ; PICKERING, Darryl S ; BREHM, Lotte ; GAJHEDE, Michael ; KROGSGAARD-LARSEN, Povl ; KASTRUP, Jette S ; KRISTENSEN, Anders S ; GREENWOOD, Jeremy R ; STRANGE, Mette ; BRAUNER-OSBORNE, Hans ; JENSEN, Anders A ; NIELSEN, Anne Sophie T ; GENESER, Ulla ; RINGGAARD, Lone M

Journal of medicinal chemistry, 2009-08, Vol.52 (15), p.4911-4922 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

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6
Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: Synthesis, modelling and molecular pharmacology
Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: Synthesis, modelling and molecular pharmacology
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Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: Synthesis, modelling and molecular pharmacology

Frølund, Bente ; Greenwood, Jeremy R. ; Holm, Mai M. ; Egebjerg, Jan ; Madsen, Ulf ; Nielsen, Birgitte ; Bräuner-Osborne, Hans ; Stensbøl, Tine B. ; Krogsgaard-Larsen, Povl

Bioorganic & medicinal chemistry, 2005-09, Vol.13 (18), p.5391-5398 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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7
Structure–Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)‑3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid
Structure–Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)‑3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid
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Structure–Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)‑3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid

Krogsgaard-Larsen, Niels ; Storgaard, Morten ; Møller, Charlotte ; Demmer, Charles S ; Hansen, Jeanette ; Han, Liwei ; Monrad, Rune N ; Nielsen, Birgitte ; Tapken, Daniel ; Pickering, Darryl S ; Kastrup, Jette S ; Frydenvang, Karla ; Bunch, Lennart

Journal of medicinal chemistry, 2015-08, Vol.58 (15), p.6131-6150 [Periódico revisado por pares]

United States: American Chemical Society

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8
Discovery of a New Class of Ionotropic Glutamate Receptor Antagonists by the Rational Design of (2S,3R)-3-(3-Carboxyphenyl)-pyrrolidine-2-carboxylic Acid
Discovery of a New Class of Ionotropic Glutamate Receptor Antagonists by the Rational Design of (2S,3R)-3-(3-Carboxyphenyl)-pyrrolidine-2-carboxylic Acid
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Discovery of a New Class of Ionotropic Glutamate Receptor Antagonists by the Rational Design of (2S,3R)-3-(3-Carboxyphenyl)-pyrrolidine-2-carboxylic Acid

Larsen, Ann M ; Venskutonytė, Raminta ; Valadés, Elena Antón ; Nielsen, Birgitte ; Pickering, Darryl S ; Bunch, Lennart

ACS chemical neuroscience, 2011-02, Vol.2 (2), p.107-114 [Periódico revisado por pares]

United States: American Chemical Society

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9
Design, Synthesis, and Pharmacology of a Highly Subtype-Selective GluR1/2 Agonist, (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic Acid (Cl-HIBO)
Design, Synthesis, and Pharmacology of a Highly Subtype-Selective GluR1/2 Agonist, (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic Acid (Cl-HIBO)
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Design, Synthesis, and Pharmacology of a Highly Subtype-Selective GluR1/2 Agonist, (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic Acid (Cl-HIBO)

Bjerrum, Esben J ; Kristensen, Anders S ; Pickering, Darryl S ; Greenwood, Jeremy R ; Nielsen, Birgitte ; Liljefors, Tommy ; Schousboe, Arne ; Bräuner-Osborne, Hans ; Madsen, Ulf

Journal of medicinal chemistry, 2003-05, Vol.46 (11), p.2246-2249 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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10
Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors
Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors
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Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

Szymanska, Ewa ; Frydenvang, Karla ; Pickering, Darryl S ; Krintel, Christian ; Nielsen, Birgitte ; Kooshki, Ayesheh ; Zachariassen, Linda G ; Olsen, Lars ; Kastrup, Jette S ; Johansen, Tommy N

Journal of medicinal chemistry, 2016-01, Vol.59 (1), p.448-461 [Periódico revisado por pares]

United States: American Chemical Society

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