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1
Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists
Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists
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Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists

Kambe, Tohru ; Maruyama, Toru ; Nakai, Yoshihiko ; Yoshida, Hideyuki ; Oida, Hiroji ; Maruyama, Takayuki ; Abe, Nobutaka ; Nishiura, Akio ; Nakai, Hisao ; Toda, Masaaki

Bioorganic & medicinal chemistry, 2012-04, Vol.20 (7), p.2235-2251 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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2
Synthesis and evaluation of novel modified γ-lactam prostanoids as EP4 subtype-selective agonists
Synthesis and evaluation of novel modified γ-lactam prostanoids as EP4 subtype-selective agonists
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Synthesis and evaluation of novel modified γ-lactam prostanoids as EP4 subtype-selective agonists

Kambe, Tohru ; Maruyama, Toru ; Nagase, Toshihiko ; Ogawa, Seiji ; Minamoto, Chiaki ; Sakata, Kiyoto ; Maruyama, Takayuki ; Nakai, Hisao ; Toda, Masaaki

Bioorganic & medicinal chemistry, 2012-01, Vol.20 (2), p.702-713 [Periódico revisado por pares]

England: Elsevier Ltd

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3
Discovery of an 8-Aza-5-thiaProstaglandin E1 Analog as a Highly Selective EP4 Receptor Agonist
Discovery of an 8-Aza-5-thiaProstaglandin E1 Analog as a Highly Selective EP4 Receptor Agonist
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Discovery of an 8-Aza-5-thiaProstaglandin E1 Analog as a Highly Selective EP4 Receptor Agonist

Kambe, Tohru ; Maruyama, Toru ; Naganawa, Atsushi ; Asada, Masaki ; Seki, Akiteru ; Maruyama, Takayuki ; Nakai, Hisao ; Toda, Masaaki

Chemical and Pharmaceutical Bulletin, 2011/12/01, Vol.59(12), pp.1494-1508 [Periódico revisado por pares]

Japan: The Pharmaceutical Society of Japan

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4
Discovery of Orally Available 8-Aza-5-thiaProstaglandin E1 Analogs as Highly Selective EP4 Agonists
Discovery of Orally Available 8-Aza-5-thiaProstaglandin E1 Analogs as Highly Selective EP4 Agonists
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Discovery of Orally Available 8-Aza-5-thiaProstaglandin E1 Analogs as Highly Selective EP4 Agonists

Kambe, Tohru ; Maruyama, Toru ; Nakano, Masayuki ; Yamaura, Yoshiyuki ; Shono, Tomoyuki ; Seki, Akiteru ; Sakata, Kiyoto ; Maruyama, Takayuki ; Nakai, Hisao ; Toda, Masaaki

Chemical and Pharmaceutical Bulletin, 2011/12/01, Vol.59(12), pp.1523-1534 [Periódico revisado por pares]

Japan: The Pharmaceutical Society of Japan

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5
Synthesis and evaluation of γ-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists
Synthesis and evaluation of γ-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists
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Synthesis and evaluation of γ-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists

Kambe, Tohru ; Maruyama, Toru ; Nakai, Yoshihiko ; Oida, Hiroji ; Maruyama, Takayuki ; Abe, Nobutaka ; Nishiura, Akio ; Nakai, Hisao ; Toda, Masaaki

Bioorganic & medicinal chemistry, 2012-06, Vol.20 (11), p.3502-3522 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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6
Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity
Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity
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Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity

Kambe, Tohru ; Maruyama, Toru ; Nakano, Masayuki ; Nakai, Yoshihiko ; Yoshida, Tadahiro ; Matsunaga, Naoki ; Oida, Hiroji ; Konaka, Akira ; Maruyama, Takayuki ; Nakai, Hisao ; Toda, Masaaki

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.396-401 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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7
Structural optimization and structure–functional selectivity relationship studies of G protein-biased EP2 receptor agonists
Structural optimization and structure–functional selectivity relationship studies of G protein-biased EP2 receptor agonists
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Structural optimization and structure–functional selectivity relationship studies of G protein-biased EP2 receptor agonists

Ogawa, Seiji ; Watanabe, Toshihide ; Moriyuki, Kazumi ; Goto, Yoshikazu ; Yamane, Shinsaku ; Watanabe, Akio ; Tsuboi, Kazuma ; Kinoshita, Atsushi ; Okada, Takuya ; Takeda, Hiroyuki ; Tani, Kousuke ; Maruyama, Toru

Bioorganic & medicinal chemistry letters, 2016-05, Vol.26 (10), p.2446-2449 [Periódico revisado por pares]

England: Elsevier Ltd

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8
Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE(1) and 9-beta-halo derivatives with improved stability
Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE(1) and 9-beta-halo derivatives with improved stability
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Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE(1) and 9-beta-halo derivatives with improved stability

Maruyama, Toru ; Asada, Masaki ; Shiraishi, Tai ; Yoshida, Hideyuki ; Maruyama, Takayuki ; Ohuchida, Shuichi ; Nakai, Hisao ; Kondo, Kigen ; Toda, Masaaki

Bioorganic & medicinal chemistry, 2002-06, Vol.10 (6), p.1743-1759 [Periódico revisado por pares]

England

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9
Discovery of G Protein-Biased EP2 Receptor Agonists
Discovery of G Protein-Biased EP2 Receptor Agonists
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Discovery of G Protein-Biased EP2 Receptor Agonists

Ogawa, Seiji ; Watanabe, Toshihide ; Sugimoto, Isamu ; Moriyuki, Kazumi ; Goto, Yoshikazu ; Yamane, Shinsaku ; Watanabe, Akio ; Tsuboi, Kazuma ; Kinoshita, Atsushi ; Kigoshi, Hideo ; Tani, Kousuke ; Maruyama, Toru

ACS medicinal chemistry letters, 2016-03, Vol.7 (3), p.306-311 [Periódico revisado por pares]

United States: American Chemical Society

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10
Discovery of Novel Seven-Membered Prostacyclin Analogues as Potent and Selective Prostaglandin FP and EP3 Dual Agonists
Discovery of Novel Seven-Membered Prostacyclin Analogues as Potent and Selective Prostaglandin FP and EP3 Dual Agonists
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Discovery of Novel Seven-Membered Prostacyclin Analogues as Potent and Selective Prostaglandin FP and EP3 Dual Agonists

Sugimoto, Isamu ; Kambe, Tohru ; Okino, Tomotaka ; Obitsu, Tetsuo ; Ohta, Nobukazu ; Nishiyama, Taihei ; Kinoshita, Akihiro ; Fujimoto, Taku ; Egashira, Hiromu ; Yamane, Shinsaku ; Shuto, Satoshi ; Tani, Kousuke ; Maruyama, Toru

ACS medicinal chemistry letters, 2017-01, Vol.8 (1), p.107-112 [Periódico revisado por pares]

United States: American Chemical Society

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