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Peripherally delivered hepatopreferential insulin analog insulin‐406 mimics the hypoglycaemia‐sparing effect of portal vein human insulin infusion in dogs
Peripherally delivered hepatopreferential insulin analog insulin‐406 mimics the hypoglycaemia‐sparing effect of portal vein human insulin infusion in dogs
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Peripherally delivered hepatopreferential insulin analog insulin‐406 mimics the hypoglycaemia‐sparing effect of portal vein human insulin infusion in dogs

Gregory, Justin M. ; Kraft, Guillaume ; Scott, Melanie F. ; Neal, Doss W. ; Farmer, Ben ; Smith, Marta S. ; Hastings, Jon R. ; Madsen, Peter ; Kjeldsen, Thomas B. ; Hostrup, Susanne ; Brand, Christian L. ; Fledelius, Christian ; Nishimura, Erica ; Cherrington, Alan D.

Diabetes, obesity & metabolism, 2019-10, Vol.21 (10), p.2294-2304

Oxford, UK: Blackwell Publishing Ltd

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2
Molecular engineering of safe and efficacious oral basal insulin
Molecular engineering of safe and efficacious oral basal insulin
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Molecular engineering of safe and efficacious oral basal insulin

Hubálek, Frantisek ; Refsgaard, Hanne H F ; Gram-Nielsen, Sanne ; Madsen, Peter ; Nishimura, Erica ; Münzel, Martin ; Brand, Christian Lehn ; Stidsen, Carsten Enggaard ; Claussen, Christian Hove ; Wulff, Erik Max ; Pridal, Lone ; Ribel, Ulla ; Kildegaard, Jonas ; Porsgaard, Trine ; Johansson, Eva ; Steensgaard, Dorte Bjerre ; Hovgaard, Lars ; Glendorf, Tine ; Hansen, Bo Falck ; Jensen, Maja Kirkegaard ; Nielsen, Peter Kresten ; Ludvigsen, Svend ; Rugh, Susanne ; Garibay, Patrick W ; Moore, Mary Courtney ; Cherrington, Alan D ; Kjeldsen, Thomas

Nature communications, 2020-07, Vol.11 (1), p.3746-9, Article 3746 [Periódico revisado por pares]

England: Nature Publishing Group

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3
Insulin analog with additional disulfide bond has increased stability and preserved activity
Insulin analog with additional disulfide bond has increased stability and preserved activity
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Insulin analog with additional disulfide bond has increased stability and preserved activity

Vinther, Tine N. ; Norrman, Mathias ; Ribel, Ulla ; Huus, Kasper ; Schlein, Morten ; Steensgaard, Dorte B. ; Pedersen, Thomas Å. ; Pettersson, Ingrid ; Ludvigsen, Svend ; Kjeldsen, Thomas ; Jensen, Knud J. ; Hubálek, František

Protein science, 2013-03, Vol.22 (3), p.296-305 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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4
Commemorating insulin's centennial: engineering insulin pharmacology towards physiology
Commemorating insulin's centennial: engineering insulin pharmacology towards physiology
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Commemorating insulin's centennial: engineering insulin pharmacology towards physiology

Kurtzhals, Peter ; Nishimura, Erica ; Haahr, Hanne ; Høeg-Jensen, Thomas ; Johansson, Eva ; Madsen, Peter ; Sturis, Jeppe ; Kjeldsen, Thomas

Trends in pharmacological sciences (Regular ed.), 2021-08, Vol.42 (8), p.620-639 [Periódico revisado por pares]

Elsevier Ltd

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5
Receptor-isoform-selective insulin analogues give tissue-preferential effects
Receptor-isoform-selective insulin analogues give tissue-preferential effects
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Receptor-isoform-selective insulin analogues give tissue-preferential effects

Vienberg, Sara G ; Bouman, Stephan D ; Sørensen, Heidi ; Stidsen, Carsten E ; Kjeldsen, Thomas ; Glendorf, Tine ; Sørensen, Anders R ; Olsen, Grith S ; Andersen, Birgitte ; Nishimura, Erica

Biochemical journal, 2011-12, Vol.440 (3), p.301-308 [Periódico revisado por pares]

England: Portland Press

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6
815-P: Enhanced Disulphide Bond Stability Contributes to the Once Weekly PD Profile of Insulin Icodec
815-P: Enhanced Disulphide Bond Stability Contributes to the Once Weekly PD Profile of Insulin Icodec
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815-P: Enhanced Disulphide Bond Stability Contributes to the Once Weekly PD Profile of Insulin Icodec

HUBALEK, FRANTISEK ; CRAMER, CHRISTIAN ; HELLEBERG, HANS ; JOHANSSON, EVA ; SCHLUCKEBIER, GERD ; STEENSGAARD, DORTE B. ; STURIS, JEPPE ; KJELDSEN, THOMAS

Diabetes (New York, N.Y.), 2023-06, Vol.72 (Supplement_1), p.1 [Periódico revisado por pares]

New York: American Diabetes Association

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7
Cell free protein synthesis versus yeast expression – A comparison using insulin as a model protein
Cell free protein synthesis versus yeast expression – A comparison using insulin as a model protein
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Cell free protein synthesis versus yeast expression – A comparison using insulin as a model protein

Jensen, Astrid B. ; Hubálek, Franta ; Stidsen, Carsten Enggaard ; Johansson, Eva ; Öberg, Fredrik Kryh ; Skjøt, Michael ; Kjeldsen, Thomas

Protein expression and purification, 2021-10, Vol.186, p.105910-105910, Article 105910 [Periódico revisado por pares]

United States: Elsevier Inc

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8
The road to the first, fully active and more stable human insulin variant with an additional disulfide bond
The road to the first, fully active and more stable human insulin variant with an additional disulfide bond
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The road to the first, fully active and more stable human insulin variant with an additional disulfide bond

Vinther, Tine N. ; Kjeldsen, Thomas B. ; Jensen, Knud J. ; Hubálek, František

Journal of peptide science, 2015-11, Vol.21 (11), p.797-806 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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9
Expression, Receptor Binding, and Biophysical Characterization of Guinea Pig Insulin desB30: A Monomeric Insulin Variant
Expression, Receptor Binding, and Biophysical Characterization of Guinea Pig Insulin desB30: A Monomeric Insulin Variant
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Expression, Receptor Binding, and Biophysical Characterization of Guinea Pig Insulin desB30: A Monomeric Insulin Variant

Engholm, Ebbe ; Hansen, Thomas H. ; Johansson, Eva ; Strauss, Holger M. ; Vinther, Tine N. ; Jensen, Knud J. ; Hubálek, Frantisek ; Kjeldsen, Thomas B.

Chembiochem : a European journal of chemical biology, 2015-04, Vol.16 (6), p.954-958 [Periódico revisado por pares]

Weinheim: WILEY-VCH Verlag

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10
Engineering of insulin receptor isoform-selective insulin analogues
Engineering of insulin receptor isoform-selective insulin analogues
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Engineering of insulin receptor isoform-selective insulin analogues

Glendorf, Tine ; Stidsen, Carsten E ; Norrman, Mathias ; Nishimura, Erica ; Sørensen, Anders R ; Kjeldsen, Thomas Shirihai, Orian S.

PloS one, 2011-05, Vol.6 (5), p.e20288 [Periódico revisado por pares]

United States: Public Library of Science

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