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Site-Directed Chemical Mutations on Abzymes: Large Rate Accelerations in the Catalysis by Exchanging the Functionalized Small Nonprotein Components
Site-Directed Chemical Mutations on Abzymes: Large Rate Accelerations in the Catalysis by Exchanging the Functionalized Small Nonprotein Components
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Site-Directed Chemical Mutations on Abzymes: Large Rate Accelerations in the Catalysis by Exchanging the Functionalized Small Nonprotein Components

Ishikawa, Fumihiro ; Shirahashi, Masato ; Hayakawa, Hiroshi ; Yamaguchi, Asako ; Hirokawa, Takatsugu ; Tsumuraya, Takeshi ; Fujii, Ikuo

ACS chemical biology, 2016-10, Vol.11 (10), p.2803-2811 [Periódico revisado por pares]

United States: American Chemical Society

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2
In vitro abzyme evolution to optimize antibody recognition for catalysis
In vitro abzyme evolution to optimize antibody recognition for catalysis
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In vitro abzyme evolution to optimize antibody recognition for catalysis

Fujii, Ikuo ; Takahashi, Naoko ; Kakinuma, Hiroyuki ; Liu, Lidong ; Nishi, Yoshisuke

Nature biotechnology, 2001-06, Vol.19 (6), p.563-567 [Periódico revisado por pares]

New York, NY: Nature

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3
Directed evolution governed by controlling the molecular recognition between an abzyme and its haptenic transition–state analog
Directed evolution governed by controlling the molecular recognition between an abzyme and its haptenic transition–state analog
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Directed evolution governed by controlling the molecular recognition between an abzyme and its haptenic transition–state analog

Takahashi-Ando, Naoko ; Kakinuma, Hiroyuki ; Fujii, Ikuo ; Nishi, Yoshisuke

Journal of immunological methods, 2004-11, Vol.294 (1), p.1-14 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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4
Structural Basis of the Transition-state Stabilization in Antibody-catalyzed Hydrolysis
Structural Basis of the Transition-state Stabilization in Antibody-catalyzed Hydrolysis
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Structural Basis of the Transition-state Stabilization in Antibody-catalyzed Hydrolysis

Sakakura, Masayoshi ; Takahashi, Hideo ; Shimba, Nobuhisa ; Fujii, Ikuo ; Shimada, Ichio

Journal of molecular biology, 2007-03, Vol.367 (1), p.133-147 [Periódico revisado por pares]

England: Elsevier Ltd

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5
Thermodynamic and Structural Basis for Transition-State Stabilization in Antibody-Catalyzed Hydrolysis
Thermodynamic and Structural Basis for Transition-State Stabilization in Antibody-Catalyzed Hydrolysis
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Thermodynamic and Structural Basis for Transition-State Stabilization in Antibody-Catalyzed Hydrolysis

Oda, Masayuki ; Ito, Nobutoshi ; Tsumuraya, Takeshi ; Suzuki, Kayo ; Sakakura, Masayoshi ; Fujii, Ikuo

Journal of molecular biology, 2007-05, Vol.369 (1), p.198-209 [Periódico revisado por pares]

England: Elsevier Ltd

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6
Molecular Mechanisms of Improvement of Hydrolytic Antibody 6D9 by Site-Directed Mutagenesis
Molecular Mechanisms of Improvement of Hydrolytic Antibody 6D9 by Site-Directed Mutagenesis
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Molecular Mechanisms of Improvement of Hydrolytic Antibody 6D9 by Site-Directed Mutagenesis

Takahashi-Ando, Naoko ; Shimazaki, Kazuko ; Kakinuma, Hiroyuki ; Fujii, Ikuo ; Nishi, Yoshisuke

Journal of biochemistry (Tokyo), 2006-10, Vol.140 (4), p.509-515 [Periódico revisado por pares]

England: Oxford University Press

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7
Expression of Fab fragment of catalytic antibody 6D9 in an Escherichia coli in vitro coupled transcription/translation system
Expression of Fab fragment of catalytic antibody 6D9 in an Escherichia coli in vitro coupled transcription/translation system
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Expression of Fab fragment of catalytic antibody 6D9 in an Escherichia coli in vitro coupled transcription/translation system

Jiang, XiuPing ; Ookubo, Yuji ; Fujii, Ikuo ; Nakano, Hideo ; Yamane, Tsuneo

FEBS letters, 2002-03, Vol.514 (2), p.290-294 [Periódico revisado por pares]

England: Elsevier B.V

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8
Selective chemotherapeutic strategies using catalytic antibodies: a common pro-moiety for antibody-directed abzyme prodrug therapy
Selective chemotherapeutic strategies using catalytic antibodies: a common pro-moiety for antibody-directed abzyme prodrug therapy
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Selective chemotherapeutic strategies using catalytic antibodies: a common pro-moiety for antibody-directed abzyme prodrug therapy

Kakinuma, Hiroyuki ; Fujii, Ikuo ; Nishi, Yoshisuke

Journal of immunological methods, 2002-11, Vol.269 (1), p.269-281 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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9
Evolving catalytic antibodies in a phage-displayed combinatorial library
Evolving catalytic antibodies in a phage-displayed combinatorial library
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Evolving catalytic antibodies in a phage-displayed combinatorial library

Fujii, Ikuo ; Fukuyama, Shiro ; Iwabuchi, Yoshiharu ; Tanimura, Ryuji

Nature biotechnology, 1998-05, Vol.16 (5), p.463-467 [Periódico revisado por pares]

New York, NY: Nature

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10
Directed Evolution of Antibody Molecules in Phage-displayed Combinatorial Libraries
Directed Evolution of Antibody Molecules in Phage-displayed Combinatorial Libraries
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Directed Evolution of Antibody Molecules in Phage-displayed Combinatorial Libraries

FUJII, Ikuo

YAKUGAKU ZASSHI, 2007/01/01, Vol.127(1), pp.91-99 [Periódico revisado por pares]

Japan: The Pharmaceutical Society of Japan

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