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1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors
1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors
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1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors

Tollefson, Michael B ; Acker, Brad A ; Jacobsen, E J ; Hughes, Robert O ; Walker, John K ; Fox, David N A ; Palmer, Michael J ; Freeman, Sandra K ; Yu, Ying ; Bond, Brian R

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (10), p.3125-3128 [Periódico revisado por pares]

England

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2
1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors
1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors
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1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors

TOLLEFSON, Michael B ; ACKER, Brad A ; JACOBSEN, E. J ; HUGHES, Robert O ; WALKER, John K ; FOX, David N. A ; PALMER, Michael J ; FREEMAN, Sandra K ; YING YU ; BOND, Brian R

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (10), p.3120-3124 [Periódico revisado por pares]

Amsterdam: Elsevier

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3
1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors
1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors
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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors

JIA, Zhaozhong J ; YANHONG WU ; HOLLENNBACH, Stanley J ; LAMBING, Joseph L ; SCARBOROUGH, Robert M ; ZHU, Bing-Yan ; WENRONG HUANG ; PENGLIE ZHANG ; YONGHONG SONG ; WOOLFREY, John ; SINHA, Uma ; ARFSTEN, Ann E ; EDWARDS, Susan T ; HUTCHALEELAHA, Athiwat

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1229-1234 [Periódico revisado por pares]

Oxford: Elsevier

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4
1-((3 S,4 S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes
1-((3 S,4 S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes
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1-((3 S,4 S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes

Andrews, Kim M. ; Beebe, David A. ; Benbow, John W. ; Boyer, David A. ; Doran, Shawn D. ; Hui, Yu ; Liu, Shenping ; McPherson, R. Kirk ; Neagu, Constantin ; Parker, Janice C. ; Piotrowski, David W. ; Schneider, Steven R. ; Treadway, Judith L. ; VanVolkenberg, Maria A. ; Zembrowski, William J.

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1810-1814 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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5
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer
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1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer

Vanderlaag, Kathy ; Su, Yunpeng ; Frankel, Arthur E ; Burghardt, Robert C ; Barhoumi, Rola ; Chadalapaka, Gayathri ; Jutooru, Indira ; Safe, Stephen

BMC cancer, 2010-12, Vol.10 (1), p.669-669, Article 669 [Periódico revisado por pares]

England: BioMed Central Ltd

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6
1,2-Benzothiazine 1,1-dioxide α-ketoamide analogues as potent calpain I inhibitors
1,2-Benzothiazine 1,1-dioxide α-ketoamide analogues as potent calpain I inhibitors
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1,2-Benzothiazine 1,1-dioxide α-ketoamide analogues as potent calpain I inhibitors

BIHOVSKY, Ron ; MING TAO ; MALLAMO, John P ; WELLS, Gregory J

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (4), p.1035-1038 [Periódico revisado por pares]

Oxford: Elsevier

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7
1,2-Dichloroethane induces cerebellum granular cell apoptosis via mitochondrial pathway in vitro and in vivo
1,2-Dichloroethane induces cerebellum granular cell apoptosis via mitochondrial pathway in vitro and in vivo
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1,2-Dichloroethane induces cerebellum granular cell apoptosis via mitochondrial pathway in vitro and in vivo

Huang, Manqi ; Zhong, Yizhou ; Lin, Li ; Liang, Boxuan ; Liu, Jun ; Jiang, Junying ; Hu, Manjiang ; Huang, Yuji ; Lin, Xi ; Lu, Lvliang ; Bian, Ziwei ; Zhong, Wenyu ; Wu, Jiejiao ; Zheng, Jiewei ; Rong, Weifeng ; Zhang, Yating ; Jiang, Liang ; Wu, Jieling ; Zhang, Xin ; Yang, Xingfen ; Hu, Qiansheng ; Huang, Zhenlie

Toxicology letters, 2020-04, Vol.322, p.87-97 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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8
1,2-Dioxetanes: Novel chemiluminescent enzyme substrates. Applications to immunoassays
1,2-Dioxetanes: Novel chemiluminescent enzyme substrates. Applications to immunoassays
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1,2-Dioxetanes: Novel chemiluminescent enzyme substrates. Applications to immunoassays

Bronstein, Irena ; Edwards, Brooks ; Voyta, John C.

Journal of bioluminescence and chemiluminescence, 1989-07, Vol.4 (1), p.99-111

Chichester, UK: John Wiley & Sons, Ltd

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9
1,2,3-Thiadiazole substituted pyrazolones as potent KDR/VEGFR-2 kinase inhibitors
1,2,3-Thiadiazole substituted pyrazolones as potent KDR/VEGFR-2 kinase inhibitors
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1,2,3-Thiadiazole substituted pyrazolones as potent KDR/VEGFR-2 kinase inhibitors

Tripathy, Rabindranath ; Ghose, Arup ; Singh, Jasbir ; Bacon, Edward R. ; Angeles, Thelma S. ; Yang, Shi X. ; Albom, Mark S. ; Aimone, Lisa D. ; Herman, Joseph L. ; Mallamo, John P.

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1793-1798 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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10
1,2,3-Triazole-Dithiocarbamate Hybrids, a Group of Novel Cell Active SIRT1 Inhibitors
1,2,3-Triazole-Dithiocarbamate Hybrids, a Group of Novel Cell Active SIRT1 Inhibitors
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1,2,3-Triazole-Dithiocarbamate Hybrids, a Group of Novel Cell Active SIRT1 Inhibitors

Zheng, Yi-Chao ; Wang, Long-Zhen ; Zhao, Li-Jie ; Zhao, Li-Juan ; Zhan, Qian-Na ; Ma, Jin-Lian ; Zhang, Bin ; Wang, Meng-Meng ; Wang, Zhi-Ru ; Li, Jin-Feng ; Liu, Ying ; Chen, Zhe-Sheng ; Shen, Dan-Dan ; Liu, Xue-Qi ; Ren, Meng ; Lv, Wen-Lei ; Zhao, Wen ; Duan, Ying-Chao ; Liu, Hong-Min

Cellular physiology and biochemistry, 2016-01, Vol.38 (1), p.185-193 [Periódico revisado por pares]

Basel, Switzerland: Cell Physiol Biochem Press GmbH & Co KG

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