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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma
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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma

Marimuthu, Adhirai ; D'Andrea, Kurt ; Lin, Paul S ; Puzanov, Igor ; Chapman, Paul B ; Zhang, Jiazhong ; Tsai, James ; Ibrahim, Prabha N ; Cho, Hanna ; West, Brian L ; Nathanson, Katherine L ; Zhang, Kam Y. J ; Zhang, Ying ; Nolop, Keith ; Schlessinger, Joseph ; Grippo, Joseph ; Shellooe, Rafe ; Zhang, Chao ; Flaherty, Keith T ; Tsang, Garson ; Powell, Ben ; Kim, Kevin B ; Wong, Bernice ; Stumm, Michael ; Ribas, Antoni ; Spevak, Wayne ; Higgins, Brian ; Sosman, Jeffrey A ; Artis, Dean R ; Habets, Gaston ; Hirth, Peter ; Burton, Elizabeth A ; Iyer, Raman ; Su, Fei ; Koehler, Astrid ; Lee, Richard J ; Bollag, Gideon ; Nguyen, Hoa ; McArthur, Grant A ; Xu, Xiaowei

Nature (London), 2010-09, Vol.467 (7315), p.596-599 [Periódico revisado por pares]

London: Nature Publishing Group

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2
A novel monoclonal antibody with improved FcγR blocking ability demonstrated non-inferior efficacy compared to IVIG in cynomolgus monkey ITP model at considerably lower dose
A novel monoclonal antibody with improved FcγR blocking ability demonstrated non-inferior efficacy compared to IVIG in cynomolgus monkey ITP model at considerably lower dose
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A novel monoclonal antibody with improved FcγR blocking ability demonstrated non-inferior efficacy compared to IVIG in cynomolgus monkey ITP model at considerably lower dose

Nakajima-Kato, Yuko ; Komai, Masato ; Yoshida, Tadashi ; Kanai, Akiko

Clinical and experimental immunology, 2023-03, Vol.211 (1), p.23-30 [Periódico revisado por pares]

England: Oxford University Press

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3
"Cytokine Storm" in the Phase I Trial of Monoclonal Antibody TGN1412: Better Understanding the Causes to Improve PreClinical Testing of Immunotherapeutics
"Cytokine Storm" in the Phase I Trial of Monoclonal Antibody TGN1412: Better Understanding the Causes to Improve PreClinical Testing of Immunotherapeutics
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"Cytokine Storm" in the Phase I Trial of Monoclonal Antibody TGN1412: Better Understanding the Causes to Improve PreClinical Testing of Immunotherapeutics

Stebbings, Richard ; Findlay, Lucy ; Edwards, Cherry ; Eastwood, David ; Bird, Chris ; North, David ; Mistry, Yogesh ; Dilger, Paula ; Liefooghe, Emily ; Cludts, Isabelle ; Fox, Bernard ; Tarrant, Gill ; Robinson, Jane ; Meager, Tony ; Dolman, Carl ; Thorpe, Susan J ; Bristow, Adrian ; Wadhwa, Meenu ; Thorpe, Robin ; Poole, Stephen

Journal of Immunology, 2007-09, Vol.179 (5), p.3325-3331 [Periódico revisado por pares]

United States: Am Assoc Immnol

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4
DU‐176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles
DU‐176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles
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DU‐176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles

FURUGOHRI, T. ; ISOBE, K. ; HONDA, Y. ; KAMISATO‐MATSUMOTO, C. ; SUGIYAMA, N. ; NAGAHARA, T. ; MORISHIMA, Y. ; SHIBANO, T.

Journal of thrombosis and haemostasis, 2008-09, Vol.6 (9), p.1542-1549 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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5
Granzyme B‐expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis‐infected cynomolgus macaques
Granzyme B‐expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis‐infected cynomolgus macaques
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Granzyme B‐expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis‐infected cynomolgus macaques

Mattila, Joshua T. ; Maiello, Pauline ; Sun, Tao ; Via, Laura E. ; Flynn, JoAnne L.

Cellular microbiology, 2015-08, Vol.17 (8), p.1085-1097 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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6
Inhibition of von Willebrand factor‐mediated platelet activation and thrombosis by the anti‐von Willebrand factor A1‐domain aptamer ARC1779
Inhibition of von Willebrand factor‐mediated platelet activation and thrombosis by the anti‐von Willebrand factor A1‐domain aptamer ARC1779
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Inhibition of von Willebrand factor‐mediated platelet activation and thrombosis by the anti‐von Willebrand factor A1‐domain aptamer ARC1779

DIENER, J. L. ; DANIEL LAGASSÉ, H. A. ; DUERSCHMIED, D. ; MERHI, Y. ; TANGUAY, J‐F. ; HUTABARAT, R. ; GILBERT, J. ; WAGNER, D. D. ; SCHAUB, R.

Journal of thrombosis and haemostasis, 2009-07, Vol.7 (7), p.1155-1162 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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7
Preclinical safety and efficacy of andexanet alfa in animal models
Preclinical safety and efficacy of andexanet alfa in animal models
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Preclinical safety and efficacy of andexanet alfa in animal models

Lu, G. ; Hollenbach, S. J. ; Baker, D. C. ; Tan, S. ; Hutchaleelaha, A. ; Curnutte, J. T. ; Conley, P. B.

Journal of thrombosis and haemostasis, 2017-09, Vol.15 (9), p.1747-1756 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

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8
Preclinical development of CAT‐354, an IL‐13 neutralizing antibody, for the treatment of severe uncontrolled asthma
Preclinical development of CAT‐354, an IL‐13 neutralizing antibody, for the treatment of severe uncontrolled asthma
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Preclinical development of CAT‐354, an IL‐13 neutralizing antibody, for the treatment of severe uncontrolled asthma

May, RD ; Monk, PD ; Cohen, ES ; Manuel, D ; Dempsey, F ; Davis, NHE ; Dodd, AJ ; Corkill, DJ ; Woods, J ; Joberty‐Candotti, C ; Conroy, LA ; Koentgen, F ; Martin, EC ; Wilson, R ; Brennan, N ; Powell, J ; Anderson, IK

British journal of pharmacology, 2012-05, Vol.166 (1), p.177-193 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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9
Age‐related telomere length dynamics in peripheral blood mononuclear cells of healthy cynomolgus monkeys measured by Flow FISH
Age‐related telomere length dynamics in peripheral blood mononuclear cells of healthy cynomolgus monkeys measured by Flow FISH
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Age‐related telomere length dynamics in peripheral blood mononuclear cells of healthy cynomolgus monkeys measured by Flow FISH

Lee, Won‐Woo ; Nam, Ki‐Hoan ; Terao, Keiji ; Yoshikawa, Yasuhiro

Immunology, 2002-04, Vol.105 (4), p.458-465 [Periódico revisado por pares]

Oxford, UK: Blackwell Science Ltd

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10
The origin of projections from the posterior cingulate and retrosplenial cortices to the anterior, medial dorsal and laterodorsal thalamic nuclei of macaque monkeys
The origin of projections from the posterior cingulate and retrosplenial cortices to the anterior, medial dorsal and laterodorsal thalamic nuclei of macaque monkeys
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The origin of projections from the posterior cingulate and retrosplenial cortices to the anterior, medial dorsal and laterodorsal thalamic nuclei of macaque monkeys

Aggleton, John P. ; Saunders, Richard C. ; Wright, Nicholas F. ; Vann, Seralynne D.

The European journal of neuroscience, 2014-01, Vol.39 (1), p.107-123 [Periódico revisado por pares]

Oxford: Blackwell Publishing Ltd

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