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Material Type: Artigo
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A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumoursFRANCIS, R. J ; SHARMA, S. K ; O'MALLEY, D ; TSIOMPANOU, E ; SHAHBAKHTI, H ; WEBLEY, S ; HOCHHAUSER, D ; HILSON, A. J ; BLAKEY, D ; BEGENT, R. H. J ; SPRINGER, C ; GREEN, A. J ; HOPE-STONE, L. D ; SENA, L ; MARTIN, J ; ADAMSON, K. L ; ROBBINS, A ; GUMBRELL, LBritish journal of cancer, 2002-09, Vol.87 (6), p.600-607 [Periódico revisado por pares]Basingstoke: Nature Publishing GroupTexto completo disponível |
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2 |
Material Type: Artigo
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Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT)MAYER, A ; SHARMA, S. K ; TOLNER, B ; MINTON, N. P ; PURDY, D ; AMLOT, P ; THARAKAN, G ; BEGENT, R. H. J ; CHESTER, K. ABritish journal of cancer, 2004-06, Vol.90 (12), p.2402-2410 [Periódico revisado por pares]Basingstoke: Nature Publishing GroupTexto completo disponível |
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3 |
Material Type: Artigo
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A33scFv-cytosine deaminase: a recombinant protein construct for antibody-directed enzyme-prodrug therapyDECKERT, P. M ; RENNER, C ; COHEN, L. S ; JUNGBLUTH, A ; RITTER, G ; BERTINO, J. R ; OLD, L. J ; WELT, SBritish journal of cancer, 2003-03, Vol.88 (6), p.937-939 [Periódico revisado por pares]Basingstoke: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Recent developments in the design of bioreductive drugsDenny, W A ; Wilson, W R ; Hay, M PBritish journal of cancer. Supplement, 1996-07, Vol.27, p.S32-S38 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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5 |
Material Type: Artigo
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Cellular glutathione as a determinant of the sensitivity of colorectal tumour cell-lines to ZD2767 antibody-directed enzyme prodrug therapy (ADEPT)MONKS, N. R ; CALVETE, J. A ; CURTIN, N. J ; BLAKEY, D. C ; EAST, S. J ; NEWELL, D. RBritish journal of cancer, 2000-07, Vol.83 (2), p.267-269 [Periódico revisado por pares]Basingstoke: Nature Publishing GroupTexto completo disponível |
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6 |
Material Type: Artigo
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Plasma clearance of an antibody-enzyme conjugate in ADEPT by monoclonal anti-enzyme : its effect on prodrug activation in vivoROGERS, G. T ; BURKE, P. J ; SHARMA, S. K ; KOODIE, R ; BODEN, J. ABritish journal of cancer, 1995-12, Vol.72 (6), p.1357-1363 [Periódico revisado por pares]Basingstoke: Nature Publishing GroupTexto completo disponível |