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Decoupling of catalysis and transition state analog binding from mutations throughout a phosphatase revealed by high-throughput enzymology
Decoupling of catalysis and transition state analog binding from mutations throughout a phosphatase revealed by high-throughput enzymology
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Decoupling of catalysis and transition state analog binding from mutations throughout a phosphatase revealed by high-throughput enzymology

Markin, Craig J ; Mokhtari, Daniel A ; Du, Siyuan ; Doukov, Tzanko ; Sunden, Fanny ; Cook, Jordan A ; Fordyce, Polly M ; Herschlag, Daniel

Proceedings of the National Academy of Sciences - PNAS, 2023-07, Vol.120 (29), p.e2219074120-e2219074120 [Periódico revisado por pares]

United States: National Academy of Sciences

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2
Characterization of Brain Neurons That Express Enzymes Mediating Neurosteroid Biosynthesis
Characterization of Brain Neurons That Express Enzymes Mediating Neurosteroid Biosynthesis
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Characterization of Brain Neurons That Express Enzymes Mediating Neurosteroid Biosynthesis

Agís-Balboa, Roberto C. ; Pinna, Graziano ; Zhubi, Adrian ; Maloku, Ekrem ; Veldic, Marin ; Costa, Erminio ; Guidotti, Alessandro

Proceedings of the National Academy of Sciences - PNAS, 2006-09, Vol.103 (39), p.14602-14607 [Periódico revisado por pares]

United States: National Academy of Sciences

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3
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
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Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

Julien, Olivier ; Zhuang, Min ; Wiita, Arun P. ; O’Donoghue, Anthony J. ; Knudsen, Giselle M. ; Craik, Charles S. ; Wells, James A.

Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (14), p.E2001-E2010 [Periódico revisado por pares]

United States: National Academy of Sciences

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4
Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions
Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions
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Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions

Sohn, Mira ; Ivanova, Pavlina ; Brown, H. Alex ; Toth, Daniel J. ; Varnai, Peter ; Kim, Yeun Ju ; Balla, Tamas

Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (16), p.4314-4319 [Periódico revisado por pares]

United States: National Academy of Sciences

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5
HDAC6 is a target for protection and regeneration following injury in the nervous system
HDAC6 is a target for protection and regeneration following injury in the nervous system
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HDAC6 is a target for protection and regeneration following injury in the nervous system

Rivieccio, Mark A ; Brochier, Camille ; Willis, Dianna E ; Walker, Breset A ; D'Annibale, Melissa A ; McLaughlin, Kathryn ; Siddiq, Ambreena ; Kozikowski, Alan P ; Jaffrey, Samie R ; Twiss, Jeffery L ; Ratan, Rajiv R ; Langley, Brett

Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (46), p.19599-19604 [Periódico revisado por pares]

United States: National Academy of Sciences

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6
Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney
Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney
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Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney

Ebrahimkhani, Mohammad R ; Daneshmand, Ali ; Mazumder, Aprotim ; Allocca, Mariacarmela ; Calvo, Jennifer A ; Abolhassani, Nona ; Jhun, Iny ; Muthupalani, Sureshkumar ; Ayata, Cenk ; Samson, Leona D

Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (45), p.E4878-E4886 [Periódico revisado por pares]

United States: National Academy of Sciences

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7
Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques
Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques
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Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

Gowrishankar, Swetha ; Yuan, Peng ; Wu, Yumei ; Schrag, Matthew ; Paradise, Summer ; Grutzendler, Jaime ; De Camilli, Pietro ; Ferguson, Shawn M.

Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (28), p.E3699-E3708 [Periódico revisado por pares]

United States: National Academy of Sciences

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8
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Xu, Ming ; Tchkonia, Tamara ; Ding, Husheng ; Ogrodnik, Mikolaj ; Lubbers, Ellen R. ; Pirtskhalava, Tamar ; White, Thomas A. ; Johnson, Kurt O. ; Stout, Michael B. ; Mezera, Vojtech ; Giorgadze, Nino ; Jensen, Michael D. ; LeBrasseur, Nathan K. ; Kirkland, James L.

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (46), p.E6301-E6310 [Periódico revisado por pares]

United States: National Academy of Sciences

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9
Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis
Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis
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Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis

Dai, Jianye ; Liang, Kai ; Zhao, Shan ; Jia, Wentong ; Liu, Yuan ; Wu, Hongkun ; Lv, Jia ; Cao, Chen ; Chen, Tao ; Zhuang, Shentian ; Hou, Xiaomeng ; Zhou, Shijie ; Zhang, Xiannian ; Chen, Xiao-Wei ; 陈晓伟 ; Huang, Yanyi ; Xiao, Rui-Ping ; Wang, Yan-Ling ; Luo, Tuoping ; Xiao, Junyu ; Wang, Chu

Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (26), p.E5896-E5905 [Periódico revisado por pares]

United States: National Academy of Sciences

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10
In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia
In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia
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In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia

Skala, Melissa C ; Riching, Kristin M ; Gendron-Fitzpatrick, Annette ; Eickhoff, Jens ; Eliceiri, Kevin W ; White, John G ; Ramanujam, Nirmala

Proceedings of the National Academy of Sciences - PNAS, 2007-12, Vol.104 (49), p.19494-19499 [Periódico revisado por pares]

United States: National Academy of Sciences

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