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1
Medicinal Chemistry of Combretastatin A4:  Present and Future Directions
Medicinal Chemistry of Combretastatin A4:  Present and Future Directions
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Medicinal Chemistry of Combretastatin A4:  Present and Future Directions

Tron, Gian Cesare ; Pirali, Tracey ; Sorba, Giovanni ; Pagliai, Francesca ; Busacca, Sara ; Genazzani, Armando A

Journal of medicinal chemistry, 2006-06, Vol.49 (11), p.3033-3044 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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2
Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity
Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity
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Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity

Xiang, Xinrong ; Dai, Zhengyi ; Luo, Baozhu ; Zhao, Ninglin ; Liu, Song ; Sui, Jing ; Huang, Jiasheng ; Zhou, Yuanzheng ; Gu, Jinlong ; Zhang, Jiangnan ; Yang, Tao ; Bao, Rui ; Luo, Youfu

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6769-6792 [Periódico revisado por pares]

United States: American Chemical Society

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3
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
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Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Garcia Fortanet, Jorge ; Chen, Christine Hiu-Tung ; Chen, Ying-Nan P ; Chen, Zhouliang ; Deng, Zhan ; Firestone, Brant ; Fekkes, Peter ; Fodor, Michelle ; Fortin, Pascal D ; Fridrich, Cary ; Grunenfelder, Denise ; Ho, Samuel ; Kang, Zhao B ; Karki, Rajesh ; Kato, Mitsunori ; Keen, Nick ; LaBonte, Laura R ; Larrow, Jay ; Lenoir, Francois ; Liu, Gang ; Liu, Shumei ; Lombardo, Franco ; Majumdar, Dyuti ; Meyer, Matthew J ; Palermo, Mark ; Perez, Lawrence ; Pu, Minying ; Ramsey, Timothy ; Sellers, William R ; Shultz, Michael D ; Stams, Travis ; Towler, Christopher ; Wang, Ping ; Williams, Sarah L ; Zhang, Ji-Hu ; LaMarche, Matthew J

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7773-7782 [Periódico revisado por pares]

United States: American Chemical Society

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4
Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)
Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)
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Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)

Hu, Jiantao ; Hu, Biao ; Wang, Mingliang ; Xu, Fuming ; Miao, Bukeyan ; Yang, Chao-Yie ; Wang, Mi ; Liu, Zhaomin ; Hayes, Daniel F ; Chinnaswamy, Krishnapriya ; Delproposto, James ; Stuckey, Jeanne ; Wang, Shaomeng

Journal of medicinal chemistry, 2019-02, Vol.62 (3), p.1420-1442 [Periódico revisado por pares]

United States: American Chemical Society

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5
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression
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Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

Zhou, Bing ; Hu, Jiantao ; Xu, Fuming ; Chen, Zhuo ; Bai, Longchuan ; Fernandez-Salas, Ester ; Lin, Mei ; Liu, Liu ; Yang, Chao-Yie ; Zhao, Yujun ; McEachern, Donna ; Przybranowski, Sally ; Wen, Bo ; Sun, Duxin ; Wang, Shaomeng

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.462-481 [Periódico revisado por pares]

United States: American Chemical Society

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6
Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro­[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)­bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development
Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro­[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)­bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development
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Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro­[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)­bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Aguilar, Angelo ; Lu, Jianfeng ; Liu, Liu ; Du, Ding ; Bernard, Denzil ; McEachern, Donna ; Przybranowski, Sally ; Li, Xiaoqin ; Luo, Ruijuan ; Wen, Bo ; Sun, Duxin ; Wang, Hengbang ; Wen, Jianfeng ; Wang, Guangfeng ; Zhai, Yifan ; Guo, Ming ; Yang, Dajun ; Wang, Shaomeng

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2819-2839 [Periódico revisado por pares]

United States: American Chemical Society

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7
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)

Rai, Ganesha ; Brimacombe, Kyle R ; Mott, Bryan T ; Urban, Daniel J ; Hu, Xin ; Yang, Shyh-Ming ; Lee, Tobie D ; Cheff, Dorian M ; Kouznetsova, Jennifer ; Benavides, Gloria A ; Pohida, Katie ; Kuenstner, Eric J ; Luci, Diane K ; Lukacs, Christine M ; Davies, Douglas R ; Dranow, David M ; Zhu, Hu ; Sulikowski, Gary ; Moore, William J ; Stott, Gordon M ; Flint, Andrew J ; Hall, Matthew D ; Darley-Usmar, Victor M ; Neckers, Leonard M ; Dang, Chi V ; Waterson, Alex G ; Simeonov, Anton ; Jadhav, Ajit ; Maloney, David J

Journal of medicinal chemistry, 2017-11, Vol.60 (22), p.9184-9204 [Periódico revisado por pares]

United States: American Chemical Society

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8
Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy
Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy
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Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy

Liu, Tingting ; Wan, Yichao ; Xiao, Yuliang ; Xia, Chengcai ; Duan, Guiyun

Journal of medicinal chemistry, 2020-09, Vol.63 (17), p.8977-9002 [Periódico revisado por pares]

United States: American Chemical Society

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9
Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Antitumor Activity in Cancer Cells That Display Resistance to Proapoptotic Stimuli: An Investigation of Structure−Activity Relationship and Mechanistic Insight
Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Antitumor Activity in Cancer Cells That Display Resistance to Proapoptotic Stimuli: An Investigation of Structure−Activity Relationship and Mechanistic Insight
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Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Antitumor Activity in Cancer Cells That Display Resistance to Proapoptotic Stimuli: An Investigation of Structure−Activity Relationship and Mechanistic Insight

Lamoral-Theys, Delphine ; Andolfi, Anna ; Van Goietsenoven, Gwendoline ; Cimmino, Alessio ; Le Calvé, Benjamin ; Wauthoz, Nathalie ; Mégalizzi, Véronique ; Gras, Thierry ; Bruyère, Céline ; Dubois, Jacques ; Mathieu, Véronique ; Kornienko, Alexander ; Kiss, Robert ; Evidente, Antonio

Journal of medicinal chemistry, 2009-10, Vol.52 (20), p.6244-6256 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

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10
1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors
1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors
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1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors

Dolbois, Aymeric ; Bedi, Rajiv K ; Bochenkova, Elena ; Müller, Anna ; Moroz-Omori, Elena V ; Huang, Danzhi ; Caflisch, Amedeo

Journal of medicinal chemistry, 2021-09, Vol.64 (17), p.12738-12760 [Periódico revisado por pares]

United States: American Chemical Society

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