skip to main content
Idioma:
Resultados 1 2 3 4 5 next page
Refinado por: Base de dados/Biblioteca: American Chemical Society Journals remover assunto: Chemistry, Medicinal remover assunto: Drug Discovery remover
Result Number Material Type Add to My Shelf Action Record Details and Options
1
Medicinal Chemistry of Combretastatin A4:  Present and Future Directions
Medicinal Chemistry of Combretastatin A4:  Present and Future Directions
Material Type:
Artigo 		Adicionar ao Meu Espaço

Medicinal Chemistry of Combretastatin A4:  Present and Future Directions

Tron, Gian Cesare ; Pirali, Tracey ; Sorba, Giovanni ; Pagliai, Francesca ; Busacca, Sara ; Genazzani, Armando A

Journal of medicinal chemistry, 2006-06, Vol.49 (11), p.3033-3044 [Periódico revisado por pares]

Washington, DC: American Chemical Society

Texto completo disponível

Citações Citado por
2
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
Material Type:
Artigo 		Adicionar ao Meu Espaço

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Garcia Fortanet, Jorge ; Chen, Christine Hiu-Tung ; Chen, Ying-Nan P ; Chen, Zhouliang ; Deng, Zhan ; Firestone, Brant ; Fekkes, Peter ; Fodor, Michelle ; Fortin, Pascal D ; Fridrich, Cary ; Grunenfelder, Denise ; Ho, Samuel ; Kang, Zhao B ; Karki, Rajesh ; Kato, Mitsunori ; Keen, Nick ; LaBonte, Laura R ; Larrow, Jay ; Lenoir, Francois ; Liu, Gang ; Liu, Shumei ; Lombardo, Franco ; Majumdar, Dyuti ; Meyer, Matthew J ; Palermo, Mark ; Perez, Lawrence ; Pu, Minying ; Ramsey, Timothy ; Sellers, William R ; Shultz, Michael D ; Stams, Travis ; Towler, Christopher ; Wang, Ping ; Williams, Sarah L ; Zhang, Ji-Hu ; LaMarche, Matthew J

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7773-7782 [Periódico revisado por pares]

United States: American Chemical Society

Texto completo disponível

Citações Citado por
3
Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers
Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers
Material Type:
Artigo 		Adicionar ao Meu Espaço

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers

Cottrell, Kevin M. ; Briggs, Kimberly J. ; Whittington, Douglas A. ; Jahic, Haris ; Ali, Janid A. ; Davis, Charles B. ; Gong, Shanzhong ; Gotur, Deepali ; Gu, Lina ; McCarren, Patrick ; Tonini, Matthew R. ; Tsai, Alice ; Wilker, Erik W. ; Yuan, Hongling ; Zhang, Minjie ; Zhang, Wenhai ; Huang, Alan ; Maxwell, John P.

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6064-6080 [Periódico revisado por pares]

United States: American Chemical Society

Texto completo disponível

Citações Citado por
4
Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro­[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)­bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development
Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro­[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)­bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development
Material Type:
Artigo 		Adicionar ao Meu Espaço

Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro­[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)­bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Aguilar, Angelo ; Lu, Jianfeng ; Liu, Liu ; Du, Ding ; Bernard, Denzil ; McEachern, Donna ; Przybranowski, Sally ; Li, Xiaoqin ; Luo, Ruijuan ; Wen, Bo ; Sun, Duxin ; Wang, Hengbang ; Wen, Jianfeng ; Wang, Guangfeng ; Zhai, Yifan ; Guo, Ming ; Yang, Dajun ; Wang, Shaomeng

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2819-2839 [Periódico revisado por pares]

United States: American Chemical Society

Texto completo disponível

Citações Citado por
5
Discovery of Potent and Selective PI3Kδ Inhibitors for the Treatment of Acute Myeloid Leukemia
Discovery of Potent and Selective PI3Kδ Inhibitors for the Treatment of Acute Myeloid Leukemia
Material Type:
Artigo 		Adicionar ao Meu Espaço

Discovery of Potent and Selective PI3Kδ Inhibitors for the Treatment of Acute Myeloid Leukemia

Tang, Yongmei ; Zheng, Yanan ; Hu, Xueping ; Zhao, Huajun ; Cui, Sunliang

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6638-6657 [Periódico revisado por pares]

United States: American Chemical Society

Texto completo disponível

Citações Citado por
6
An Update on Poly(ADP-ribose)polymerase‑1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy
An Update on Poly(ADP-ribose)polymerase‑1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy
Material Type:
Artigo 		Adicionar ao Meu Espaço

An Update on Poly(ADP-ribose)polymerase‑1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy

Wang, Ying-Qing ; Wang, Ping-Yuan ; Wang, Yu-Ting ; Yang, Guang-Fu ; Zhang, Ao ; Miao, Ze-Hong

Journal of medicinal chemistry, 2016-11, Vol.59 (21), p.9575-9598 [Periódico revisado por pares]

United States: American Chemical Society

Texto completo disponível

Citações Citado por
7
Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents
Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents
Material Type:
Artigo 		Adicionar ao Meu Espaço

Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents

Chen, Hao ; Deng, Shanshan ; Albadari, Najah ; Yun, Mi-Kyung ; Zhang, Sicheng ; Li, Yong ; Ma, Dejian ; Parke, Deanna N ; Yang, Lei ; Seagroves, Tiffany N ; White, Stephen W ; Miller, Duane D ; Li, Wei

Journal of medicinal chemistry, 2021-08, Vol.64 (16), p.12049-12074 [Periódico revisado por pares]

United States

Texto completo disponível

Citações Citado por
8
Selectively Nonselective Kinase Inhibition: Striking the Right Balance
Selectively Nonselective Kinase Inhibition: Striking the Right Balance
Material Type:
Artigo 		Adicionar ao Meu Espaço

Selectively Nonselective Kinase Inhibition: Striking the Right Balance

Morphy, Richard

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1413-1437 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

Texto completo disponível

Citações Citado por
9
Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression
Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression
Material Type:
Artigo 		Adicionar ao Meu Espaço

Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression

Rej, Rohan Kalyan ; Wang, Changwei ; Lu, Jianfeng ; Wang, Mi ; Petrunak, Elyse ; Zawacki, Kaitlin P ; McEachern, Donna ; Yang, Chao-Yie ; Wang, Lu ; Li, Ruiting ; Chinnaswamy, Krishnapriya ; Wen, Bo ; Sun, Duxin ; Stuckey, Jeanne A ; Zhou, Yunlong ; Chen, Jianyong ; Tang, Guozhi ; Wang, Shaomeng

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14540-14556 [Periódico revisado por pares]

United States: American Chemical Society

Texto completo disponível

Citações Citado por
10
Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure–Activity Relationships
Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure–Activity Relationships
Material Type:
Artigo 		Adicionar ao Meu Espaço

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure–Activity Relationships

Leung, Leo ; Niculescu-Duvaz, Dan ; Smithen, Deborah ; Lopes, Filipa ; Callens, Cedric ; McLeary, Robert ; Saturno, Grazia ; Davies, Lawrence ; Aljarah, Mohammed ; Brown, Michael ; Johnson, Louise ; Zambon, Alfonso ; Chambers, Tim ; Ménard, Delphine ; Bayliss, Natasha ; Knight, Ruth ; Fish, Laura ; Lawrence, Rae ; Challinor, Mairi ; Tang, HaoRan ; Marais, Richard ; Springer, Caroline

Journal of medicinal chemistry, 2019-06, Vol.62 (12), p.5863-5884 [Periódico revisado por pares]

United States: American Chemical Society

Texto completo disponível

Citações Citado por
Resultados 1 2 3 4 5 next page

Personalize Seus Resultados

  1. Editar

Refine Search Results

Expandir Meus Resultados

  1.   

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.