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Refinado por: Base de dados/Biblioteca: American Chemical Society Journals remover assunto: Cell Line, Tumor remover assunto: Chemistry, Medicinal remover
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Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity
Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity
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Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity

Xiang, Xinrong ; Dai, Zhengyi ; Luo, Baozhu ; Zhao, Ninglin ; Liu, Song ; Sui, Jing ; Huang, Jiasheng ; Zhou, Yuanzheng ; Gu, Jinlong ; Zhang, Jiangnan ; Yang, Tao ; Bao, Rui ; Luo, Youfu

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6769-6792 [Periódico revisado por pares]

United States: American Chemical Society

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2
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
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Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Garcia Fortanet, Jorge ; Chen, Christine Hiu-Tung ; Chen, Ying-Nan P ; Chen, Zhouliang ; Deng, Zhan ; Firestone, Brant ; Fekkes, Peter ; Fodor, Michelle ; Fortin, Pascal D ; Fridrich, Cary ; Grunenfelder, Denise ; Ho, Samuel ; Kang, Zhao B ; Karki, Rajesh ; Kato, Mitsunori ; Keen, Nick ; LaBonte, Laura R ; Larrow, Jay ; Lenoir, Francois ; Liu, Gang ; Liu, Shumei ; Lombardo, Franco ; Majumdar, Dyuti ; Meyer, Matthew J ; Palermo, Mark ; Perez, Lawrence ; Pu, Minying ; Ramsey, Timothy ; Sellers, William R ; Shultz, Michael D ; Stams, Travis ; Towler, Christopher ; Wang, Ping ; Williams, Sarah L ; Zhang, Ji-Hu ; LaMarche, Matthew J

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7773-7782 [Periódico revisado por pares]

United States: American Chemical Society

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3
Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers
Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers
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Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers

Cottrell, Kevin M. ; Briggs, Kimberly J. ; Whittington, Douglas A. ; Jahic, Haris ; Ali, Janid A. ; Davis, Charles B. ; Gong, Shanzhong ; Gotur, Deepali ; Gu, Lina ; McCarren, Patrick ; Tonini, Matthew R. ; Tsai, Alice ; Wilker, Erik W. ; Yuan, Hongling ; Zhang, Minjie ; Zhang, Wenhai ; Huang, Alan ; Maxwell, John P.

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6064-6080 [Periódico revisado por pares]

United States: American Chemical Society

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4
Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)
Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)
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Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)

Hu, Jiantao ; Hu, Biao ; Wang, Mingliang ; Xu, Fuming ; Miao, Bukeyan ; Yang, Chao-Yie ; Wang, Mi ; Liu, Zhaomin ; Hayes, Daniel F ; Chinnaswamy, Krishnapriya ; Delproposto, James ; Stuckey, Jeanne ; Wang, Shaomeng

Journal of medicinal chemistry, 2019-02, Vol.62 (3), p.1420-1442 [Periódico revisado por pares]

United States: American Chemical Society

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5
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression
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Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

Zhou, Bing ; Hu, Jiantao ; Xu, Fuming ; Chen, Zhuo ; Bai, Longchuan ; Fernandez-Salas, Ester ; Lin, Mei ; Liu, Liu ; Yang, Chao-Yie ; Zhao, Yujun ; McEachern, Donna ; Przybranowski, Sally ; Wen, Bo ; Sun, Duxin ; Wang, Shaomeng

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.462-481 [Periódico revisado por pares]

United States: American Chemical Society

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6
Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro­[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)­bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development
Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro­[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)­bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development
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Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro­[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)­bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Aguilar, Angelo ; Lu, Jianfeng ; Liu, Liu ; Du, Ding ; Bernard, Denzil ; McEachern, Donna ; Przybranowski, Sally ; Li, Xiaoqin ; Luo, Ruijuan ; Wen, Bo ; Sun, Duxin ; Wang, Hengbang ; Wen, Jianfeng ; Wang, Guangfeng ; Zhai, Yifan ; Guo, Ming ; Yang, Dajun ; Wang, Shaomeng

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2819-2839 [Periódico revisado por pares]

United States: American Chemical Society

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7
1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors
1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors
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1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors

Dolbois, Aymeric ; Bedi, Rajiv K ; Bochenkova, Elena ; Müller, Anna ; Moroz-Omori, Elena V ; Huang, Danzhi ; Caflisch, Amedeo

Journal of medicinal chemistry, 2021-09, Vol.64 (17), p.12738-12760 [Periódico revisado por pares]

United States: American Chemical Society

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8
Discovery of Potent and Selective PI3Kδ Inhibitors for the Treatment of Acute Myeloid Leukemia
Discovery of Potent and Selective PI3Kδ Inhibitors for the Treatment of Acute Myeloid Leukemia
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Discovery of Potent and Selective PI3Kδ Inhibitors for the Treatment of Acute Myeloid Leukemia

Tang, Yongmei ; Zheng, Yanan ; Hu, Xueping ; Zhao, Huajun ; Cui, Sunliang

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6638-6657 [Periódico revisado por pares]

United States: American Chemical Society

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9
Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents
Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents
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Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents

Chen, Hao ; Deng, Shanshan ; Albadari, Najah ; Yun, Mi-Kyung ; Zhang, Sicheng ; Li, Yong ; Ma, Dejian ; Parke, Deanna N ; Yang, Lei ; Seagroves, Tiffany N ; White, Stephen W ; Miller, Duane D ; Li, Wei

Journal of medicinal chemistry, 2021-08, Vol.64 (16), p.12049-12074 [Periódico revisado por pares]

United States

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10
Discovery of the Irreversible Covalent FGFR Inhibitor 8‑(3-(4-Acryloyl­piperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)­pyrido[2,3‑d]­pyrimidin-7(8H)‑one (PRN1371) for the Treatment of Solid Tumors
Discovery of the Irreversible Covalent FGFR Inhibitor 8‑(3-(4-Acryloyl­piperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)­pyrido[2,3‑d]­pyrimidin-7(8H)‑one (PRN1371) for the Treatment of Solid Tumors
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Discovery of the Irreversible Covalent FGFR Inhibitor 8‑(3-(4-Acryloyl­piperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)­pyrido[2,3‑d]­pyrimidin-7(8H)‑one (PRN1371) for the Treatment of Solid Tumors

Brameld, Ken A ; Owens, Timothy D ; Verner, Erik ; Venetsanakos, Eleni ; Bradshaw, J. Michael ; Phan, Vernon T ; Tam, Danny ; Leung, Kwan ; Shu, Jin ; LaStant, Jacob ; Loughhead, David G ; Ton, Tony ; Karr, Dane E ; Gerritsen, Mary E ; Goldstein, David M ; Funk, Jens Oliver

Journal of medicinal chemistry, 2017-08, Vol.60 (15), p.6516-6527 [Periódico revisado por pares]

United States: American Chemical Society

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