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Using human genetics to understand the disease impacts of testosterone in men and women
Using human genetics to understand the disease impacts of testosterone in men and women
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Using human genetics to understand the disease impacts of testosterone in men and women

Ruth, Katherine S ; Day, Felix R ; Tyrrell, Jessica ; Thompson, Deborah J ; Wood, Andrew R ; Mahajan, Anubha ; Beaumont, Robin N ; Wittemans, Laura ; Martin, Susan ; Busch, Alexander S ; Erzurumluoglu, A Mesut ; Hollis, Benjamin ; O'Mara, Tracy A ; McCarthy, Mark I ; Langenberg, Claudia ; Easton, Douglas F ; Wareham, Nicholas J ; Burgess, Stephen ; Murray, Anna ; Ong, Ken K ; Frayling, Timothy M ; Perry, John R B

Nature medicine, 2020-02, Vol.26 (2), p.252-258 [Periódico revisado por pares]

United States: Nature Publishing Group

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2
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
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Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

Jones, Samuel E ; Lane, Jacqueline M ; Wood, Andrew R ; van Hees, Vincent T ; Tyrrell, Jessica ; Beaumont, Robin N ; Jeffries, Aaron R ; Dashti, Hassan S ; Hillsdon, Melvyn ; Ruth, Katherine S ; Tuke, Marcus A ; Yaghootkar, Hanieh ; Sharp, Seth A ; Jie, Yingjie ; Thompson, William D ; Harrison, Jamie W ; Dawes, Amy ; Byrne, Enda M ; Tiemeier, Henning ; Allebrandt, Karla V ; Bowden, Jack ; Ray, David W ; Freathy, Rachel M ; Murray, Anna ; Mazzotti, Diego R ; Gehrman, Philip R ; Lawlor, Debbie A ; Frayling, Timothy M ; Rutter, Martin K ; Hinds, David A ; Saxena, Richa ; Weedon, Michael N

Nature communications, 2019-01, Vol.10 (1), p.343-11, Article 343 [Periódico revisado por pares]

England: Nature Publishing Group

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3
Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting
Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting
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Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting

Wright, Caroline F. ; West, Ben ; Tuke, Marcus ; Jones, Samuel E. ; Patel, Kashyap ; Laver, Thomas W. ; Beaumont, Robin N. ; Tyrrell, Jessica ; Wood, Andrew R. ; Frayling, Timothy M. ; Hattersley, Andrew T. ; Weedon, Michael N.

American journal of human genetics, 2019-02, Vol.104 (2), p.275-286 [Periódico revisado por pares]

United States: Elsevier Inc

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4
Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis
Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis
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Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis

Sharp, Seth A ; Rich, Stephen S ; Wood, Andrew R ; Jones, Samuel E ; Beaumont, Robin N ; Harrison, James W ; Schneider, Darius A ; Locke, Jonathan M ; Tyrrell, Jess ; Weedon, Michael N ; Hagopian, William A ; Oram, Richard A

Diabetes care, 2019-02, Vol.42 (2), p.200-207 [Periódico revisado por pares]

United States: American Diabetes Association

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5
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
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Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes

Wang, Heming ; Lane, Jacqueline M ; Jones, Samuel E ; Dashti, Hassan S ; Ollila, Hanna M ; Wood, Andrew R ; van Hees, Vincent T ; Brumpton, Ben ; Winsvold, Bendik S ; Kantojärvi, Katri ; Palviainen, Teemu ; Cade, Brian E ; Sofer, Tamar ; Song, Yanwei ; Patel, Krunal ; Anderson, Simon G ; Bechtold, David A ; Bowden, Jack ; Emsley, Richard ; Kyle, Simon D ; Little, Max A ; Loudon, Andrew S ; Scheer, Frank A J L ; Purcell, Shaun M ; Richmond, Rebecca C ; Spiegelhalder, Kai ; Tyrrell, Jessica ; Zhu, Xiaofeng ; Hublin, Christer ; Kaprio, Jaakko A ; Kristiansson, Kati ; Sulkava, Sonja ; Paunio, Tiina ; Hveem, Kristian ; Nielsen, Jonas B ; Willer, Cristen J ; Zwart, John-Anker ; Strand, Linn B ; Frayling, Timothy M ; Ray, David ; Lawlor, Deborah A ; Rutter, Martin K ; Weedon, Michael N ; Redline, Susan ; Saxena, Richa

Nature communications, 2019-08, Vol.10 (1), p.3503-12, Article 3503 [Periódico revisado por pares]

England: Nature Publishing Group

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6
Higher adiposity and mental health: causal inference using Mendelian randomization
Higher adiposity and mental health: causal inference using Mendelian randomization
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Higher adiposity and mental health: causal inference using Mendelian randomization

Casanova, Francesco ; O’Loughlin, Jessica ; Martin, Susan ; Beaumont, Robin N ; Wood, Andrew R ; Watkins, Edward R ; Freathy, Rachel M ; Hagenaars, Saskia P ; Frayling, Timothy M ; Yaghootkar, Hanieh ; Tyrrell, Jess

Human molecular genetics, 2021-11, Vol.30 (24), p.2371-2382 [Periódico revisado por pares]

England: Oxford University Press

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7
Association of maternal circulating 25(OH)D and calcium with birth weight: A mendelian randomisation analysis
Association of maternal circulating 25(OH)D and calcium with birth weight: A mendelian randomisation analysis
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Association of maternal circulating 25(OH)D and calcium with birth weight: A mendelian randomisation analysis

Thompson, William D ; Tyrrell, Jessica ; Borges, Maria-Carolina ; Beaumont, Robin N ; Knight, Bridget A ; Wood, Andrew R ; Ring, Susan M ; Hattersley, Andrew T ; Freathy, Rachel M ; Lawlor, Debbie A Myers, Jenny E

PLoS medicine, 2019-06, Vol.16 (6), p.e1002828-e1002828 [Periódico revisado por pares]

United States: Public Library of Science

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8
Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing
Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing
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Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

Harries, Lorna W. ; Hernandez, Dena ; Henley, William ; Wood, Andrew R. ; Holly, Alice C. ; Bradley‐Smith, Rachel M. ; Yaghootkar, Hanieh ; Dutta, Ambarish ; Murray, Anna ; Frayling, Timothy M. ; Guralnik, Jack M. ; Bandinelli, Stefania ; Singleton, Andrew ; Ferrucci, Luigi ; Melzer, David

Aging cell, 2011-10, Vol.10 (5), p.868-878 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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9
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers
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Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers

Pilling, Luke C ; Atkins, Janice L ; Duff, Michael O ; Beaumont, Robin N ; Jones, Samuel E ; Tyrrell, Jessica ; Kuo, Chia-Ling ; Ruth, Katherine S ; Tuke, Marcus A ; Yaghootkar, Hanieh ; Wood, Andrew R ; Murray, Anna ; Weedon, Michael N ; Harries, Lorna W ; Kuchel, George A ; Ferrucci, Luigi ; Frayling, Timothy M ; Melzer, David Arking, Dan E.

PloS one, 2017-09, Vol.12 (9), p.e0185083-e0185083 [Periódico revisado por pares]

United States: Public Library of Science

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10
Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation
Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation
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Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation

Wood, Andrew R ; Perry, John R B ; Tanaka, Toshiko ; Hernandez, Dena G ; Zheng, Hou-Feng ; Melzer, David ; Gibbs, J Raphael ; Nalls, Michael A ; Weedon, Michael N ; Spector, Tim D ; Richards, J Brent ; Bandinelli, Stefania ; Ferrucci, Luigi ; Singleton, Andrew B ; Frayling, Timothy M Arking, Dan E.

PloS one, 2013-05, Vol.8 (5), p.e64343-e64343 [Periódico revisado por pares]

United States: Public Library of Science

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