6-Substituted quinolines as RORγt inverse agonists

Barbay, J. Kent ; Cummings, Maxwell D. ; Abad, Marta ; Castro, Glenda ; Kreutter, Kevin D. ; Kummer, David A. ; Maharoof, Umar ; Milligan, Cynthia ; Nishimura, Rachel ; Pierce, Joan ; Schalk-Hihi, Celine ; Spurlino, John ; Tanis, Virginia M. ; Urbanski, Maud ; Venkatesan, Hariharan ; Wang, Aihua ; Woods, Craig ; Wolin, Ronald ; Xue, Xiaohua ; Edwards, James P. ; Fourie, Anne M. ; Leonard, Kristi

England: Elsevier Ltd

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Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis

Andrews, Martin J.I. ; Andrew Clase, J. ; Bar, Gregory ; Tricarico, Giovanni ; Edwards, Paul J. ; Brys, Reginald ; Chambers, Mark ; Schmidt, Wolfgang ; MacLeod, Angus ; Hirst, Kim ; Allen, Vivienne ; Birault, Veronique ; Le, Joelle ; Harris, John ; Self, Andrew ; Nash, Kevin ; Dixon, Graham

Amsterdam: Elsevier Ltd

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A new family of H3 receptor antagonists based on the natural product Conessine

SANTORA, Vincent J ; COVEL, Jonathan A ; WEBB, Robert R ; SAGE, Carleton ; REN, Albert ; PEREIRA, Guilherme ; KNUDSEN, Jens ; EDWARDS, Jeffrey E ; SUAREZ, Marissa ; FRAZER, John ; THOMSEN, William ; HAUSER, Erin ; HAYASHI, Rena ; WHELAN, Kevin ; GROTTICK, Andrew J ; HOFILENA, Brian J ; IBARRA, Jason B ; PULLEY, Michelle D ; WEINHOUSE, Michael I ; SENGUPTA, Dipanjan ; DUFFIELD, Jonathan J ; SEMPLE, Graeme

Oxford: Elsevier

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Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists

Han, Sangdon ; Thoresen, Lars ; Zhu, Xiuwen ; Narayanan, Sanju ; Jung, Jae-Kyu ; Strah-Pleynet, Sonja ; Decaire, Marc ; Choi, Karoline ; Xiong, Yifeng ; Yue, Dawei ; Semple, Graeme ; Thatte, Jayant ; Solomon, Michelle ; Fu, Lixia ; Whelan, Kevin ; Al-Shamma, Hussien ; Gatlin, Joel ; Chen, Ruoping ; Dang, Huong ; Pride, Cameron ; Gaidarov, Ibragim ; Unett, David J ; Behan, Dominic P ; Sadeque, Abu ; Usmani, Khawja A ; Chen, Chuan ; Edwards, Jeffrey ; Morgan, Michael ; Jones, Robert M

England

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Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxam i des as potent and selective CB sub(2) receptor agonists

Han, Sangdon ; Thoresen, Lars ; Zhu, Xiuwen ; Narayanan, Sanju ; Jung, Jae-Kyu ; Strah-Pleynet, Sonja ; Decaire, Marc ; Choi, Karoline ; Xiong, Yifeng ; Yue, Dawei ; Semple, Graeme ; Thatte, Jayant ; Solomon, Michelle ; Fu, Lixia ; Whelan, Kevin ; Al-Shamma, Hussien ; Gatlin, Joel ; Chen, Ruoping ; Dang, Huong ; Pride, Cameron ; Gaidarov, Ibragim ; Unett, David J ; Behan, Dominic P ; Sadeque, Abu ; Usmani, Khawja A ; Chen, Chuan ; Edwards, Jeffrey ; Morgan, Michael ; Jones, Robert M

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A new family of H 3 receptor antagonists based on the natural product Conessine

Santora, Vincent J. ; Covel, Jonathan A. ; Hayashi, Rena ; Hofilena, Brian J. ; Ibarra, Jason B. ; Pulley, Michelle D. ; Weinhouse, Michael I. ; Sengupta, Dipanjan ; Duffield, Jonathan J. ; Semple, Graeme ; Webb, Robert R. ; Sage, Carleton ; Ren, Albert ; Pereira, Guilherme ; Knudsen, Jens ; Edwards, Jeffrey E. ; Suarez, Marissa ; Frazer, John ; Thomsen, William ; Hauser, Erin ; Whelan, Kevin ; Grottick, Andrew J.

Elsevier Ltd

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The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors

Grice, Cheryl A. ; Tays, Kevin ; Khatuya, Haripada ; Gustin, Darin J. ; Butler, Christopher R. ; Wei, Jianmei ; Sehon, Clark A. ; Sun, Siquan ; Gu, Yin ; Jiang, Wen ; Thurmond, Robin L. ; Karlsson, Lars ; Edwards, James P.

Oxford: Elsevier Ltd

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Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease

Buzard, Daniel J. ; Han, Sangdon ; Lopez, Luis ; Kawasaki, Andrew ; Moody, Jeanne ; Thoresen, Lars ; Ullman, Brett ; Lehmann, Juerg ; Calderon, Imelda ; Zhu, Xiuwen ; Gharbaoui, Tawfik ; Sengupta, Dipanjan ; Krishnan, Ashwin ; Gao, Yinghong ; Edwards, Jeff ; Barden, Jeremy ; Morgan, Michael ; Usmani, Khawja ; Chen, Chuan ; Sadeque, Abu ; Thatte, Jayant ; Solomon, Michelle ; Fu, Lixia ; Whelan, Kevin ; Liu, Ling ; Al-Shamma, Hussien ; Gatlin, Joel ; Le, Minh ; Xing, Charles ; Espinola, Sheryll ; Jones, Robert M.

Amsterdam: Elsevier Ltd

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Enhanced Pneumocystis carinii activity of new primaquine analogues

Goodwin, Thomas E ; Boylan, Carole J ; Current, William L ; Byrd, John C ; Edwards, Clint B ; Fuller, Danny A ; Green, Jennifer L ; Larocca, Christine D ; Raney, Kevin D ; Ross, Ashley S ; Tucker, W.Andrew

Oxford: Elsevier Ltd

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