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1 |
Material Type: Artigo
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mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cellsKomatsu, N ; Fujita, Y ; Matsuda, M ; Aoki, KOncogene, 2015-11, Vol.34 (45), p.5607-5616 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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2 |
Material Type: Artigo
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Overcoming mTOR resistance mutations with a new-generation mTOR inhibitorRodrik-Outmezguine, Vanessa S ; Okaniwa, Masanori ; Yao, Zhan ; Novotny, Chris J ; McWhirter, Claire ; Banaji, Arpitha ; Won, Helen ; Wong, Wai ; Berger, Mike ; de Stanchina, Elisa ; Barratt, Derek G ; Cosulich, Sabina ; Klinowska, Teresa ; Rosen, Neal ; Shokat, Kevan MNature (London), 2016-06, Vol.534 (7606), p.272-276 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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3 |
Material Type: Artigo
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Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activationSu, Xiaodi ; Yu, Yingpu ; Zhong, Yi ; Giannopoulou, Eugenia G ; Hu, Xiaoyu ; Liu, Hui ; Cross, Justin R ; Rätsch, Gunnar ; Rice, Charles M ; Ivashkiv, Lionel BNature immunology, 2015-08, Vol.16 (8), p.838-849 [Periódico revisado por pares]United States: Nature Publishing GroupTexto completo disponível |
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4 |
Material Type: Artigo
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MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signalingWang, Wei ; Shen, Tao ; Dong, Bingning ; Creighton, Chad J ; Meng, Yanling ; Zhou, Wolong ; Shi, Qing ; Zhou, Hao ; Zhang, Yinjie ; Moore, David D ; Yang, FengThe Journal of clinical investigation, 2019-03, Vol.129 (3), p.1015-1029 [Periódico revisado por pares]United States: American Society for Clinical InvestigationTexto completo disponível |
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5 |
Material Type: Artigo
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mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6Nazio, Francesca ; Strappazzon, Flavie ; Antonioli, Manuela ; Bielli, Pamela ; Cianfanelli, Valentina ; Bordi, Matteo ; Gretzmeier, Christine ; Dengjel, Joern ; Piacentini, Mauro ; Fimia, Gian Maria ; Cecconi, FrancescoNature cell biology, 2013-04, Vol.15 (4), p.406-416 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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6 |
Material Type: Artigo
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mTOR at the nexus of nutrition, growth, ageing and diseaseLiu, Grace Y ; Sabatini, David MNature reviews. Molecular cell biology, 2020-04, Vol.21 (4), p.183-203 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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7 |
Material Type: Artigo
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Huntingtin functions as a scaffold for selective macroautophagyRui, Yan-Ning ; Xu, Zhen ; Patel, Bindi ; Chen, Zhihua ; Chen, Dongsheng ; Tito, Antonio ; David, Gabriela ; Sun, Yamin ; Stimming, Erin F ; Bellen, Hugo J ; Cuervo, Ana Maria ; Zhang, ShengNature cell biology, 2015-03, Vol.17 (3), p.262-275 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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8 |
Material Type: Artigo
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Concurrent Alterations in EGFR-Mutant Lung Cancers Associated with Resistance to EGFR Kinase Inhibitors and Characterization of MTOR as a Mediator of ResistanceYu, Helena A ; Suzawa, Ken ; Jordan, Emmet ; Zehir, Ahmet ; Ni, Ai ; Kim, Ryan ; Kris, Mark G ; Hellmann, Matthew D ; Li, Bob T ; Somwar, Romel ; Solit, David B ; Berger, Michael F ; Arcila, Maria ; Riely, Gregory J ; Ladanyi, MarcClinical cancer research, 2018-07, Vol.24 (13), p.3108-3118 [Periódico revisado por pares]United States: American Association for Cancer Research IncTexto completo disponível |
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9 |
Material Type: Artigo
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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translationLaberge, Remi-Martin ; Sun, Yu ; Orjalo, Arturo V ; Patil, Christopher K ; Freund, Adam ; Zhou, Lili ; Curran, Samuel C ; Davalos, Albert R ; Wilson-Edell, Kathleen A ; Liu, Su ; Limbad, Chandani ; Demaria, Marco ; Li, Patrick ; Hubbard, Gene B ; Ikeno, Yuji ; Javors, Martin ; Desprez, Pierre-Yves ; Benz, Christopher C ; Kapahi, Pankaj ; Nelson, Peter S ; Campisi, JudithNature cell biology, 2015-08, Vol.17 (8), p.1049-1061 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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10 |
Material Type: Artigo
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Amino Acids Regulate mTORC1 by an Obligate Two-step MechanismDyachok, Julia ; Earnest, Svetlana ; Iturraran, Erica N. ; Cobb, Melanie H. ; Ross, Elliott M.The Journal of biological chemistry, 2016-10, Vol.291 (43), p.22414-22426 [Periódico revisado por pares]United States: Elsevier IncTexto completo disponível |