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Design and Synthesis of N‑Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs
Design and Synthesis of N‑Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs
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Design and Synthesis of N‑Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs

Engers, Julie L ; Bollinger, Katrina A ; Weiner, Rebecca L ; Rodriguez, Alice L ; Long, Madeline F ; Breiner, Megan M ; Chang, Sichen ; Bollinger, Sean R ; Bubser, Michael ; Jones, Carrie K ; Morrison, Ryan D ; Bridges, Thomas M ; Blobaum, Anna L ; Niswender, Colleen M ; Conn, P. Jeffrey ; Emmitte, Kyle A ; Lindsley, Craig W

ACS medicinal chemistry letters, 2017-09, Vol.8 (9), p.925-930 [Periódico revisado por pares]

American Chemical Society

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2
VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate
VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate
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VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate

Engers, Darren W. ; Melancon, Bruce J. ; Gregro, Allison R. ; Bertron, Jeanette L. ; Bollinger, Sean R. ; Felts, Andrew S. ; Konkol, Leah C. ; Wood, Michael R. ; Bollinger, Katrina A. ; Luscombe, Vincent B. ; Rodriguez, Alice L. ; Jones, Carrie K. ; Bubser, Michael ; Yohn, Samantha E. ; Wood, Michael W. ; Brandon, Nicholas J. ; Dugan, Mark E. ; Niswender, Colleen M. ; Conn, P. Jeffrey ; Bridges, Thomas M. ; Lindsley, Craig W.

Bioorganic & medicinal chemistry letters, 2019-07, Vol.29 (14), p.1714-1718 [Periódico revisado por pares]

Elsevier Ltd

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3
VU6005806/AZN-00016130, an advanced M 4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate
VU6005806/AZN-00016130, an advanced M 4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate
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VU6005806/AZN-00016130, an advanced M 4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate

Engers, Darren W ; Melancon, Bruce J ; Gregro, Allison R ; Bertron, Jeanette L ; Bollinger, Sean R ; Felts, Andrew S ; Konkol, Leah C ; Wood, Michael R ; Bollinger, Katrina A ; Luscombe, Vincent B ; Rodriguez, Alice L ; Jones, Carrie K ; Bubser, Michael ; Yohn, Samantha E ; Wood, Michael W ; Brandon, Nicholas J ; Dugan, Mark E ; Niswender, Colleen M ; Jeffrey Conn, P ; Bridges, Thomas M ; Lindsley, Craig W

Bioorganic & medicinal chemistry letters, 2019-07, Vol.29 (14), p.1714 [Periódico revisado por pares]

England

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4
Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5
Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5
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Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Felts, Andrew S. ; Bollinger, Katrina A. ; Brassard, Christopher J. ; Rodriguez, Alice L. ; Morrison, Ryan D. ; Scott Daniels, J. ; Blobaum, Anna L. ; Niswender, Colleen M. ; Jones, Carrie K. ; Jeffrey Conn, P. ; Emmitte, Kyle A. ; Lindsley, Craig W.

Bioorganic & medicinal chemistry letters, 2019-01, Vol.29 (1), p.47-50 [Periódico revisado por pares]

England: Elsevier Ltd

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5
Novel M 4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands
Novel M 4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands
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Novel M 4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands

Poslusney, Michael S ; Salovich, James M ; Wood, Michael R ; Melancon, Bruce J ; Bollinger, Katrina A ; Luscombe, Vincent B ; Rodriguez, Alice L ; Engers, Darren W ; Bridges, Thomas M ; Niswender, Colleen M ; Conn, P Jeffrey ; Lindsley, Craig W

Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (3), p.362 [Periódico revisado por pares]

England

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6
Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands
Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands
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Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands

Poslusney, Michael S. ; Salovich, James M. ; Wood, Michael R. ; Melancon, Bruce J. ; Bollinger, Katrina A. ; Luscombe, Vincent B. ; Rodriguez, Alice L. ; Engers, Darren W. ; Bridges, Thomas M. ; Niswender, Colleen M. ; Conn, P. Jeffrey ; Lindsley, Craig W.

Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (3), p.362-366 [Periódico revisado por pares]

Elsevier Ltd

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7
Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core
Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core
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Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core

Bollinger, Katrina A ; Felts, Andrew S ; Brassard, Christopher J ; Engers, Julie L ; Rodriguez, Alice L ; Weiner, Rebecca L ; Cho, Hyekyung P ; Chang, Sichen ; Bubser, Michael ; Jones, Carrie K ; Blobaum, Anna L ; Niswender, Colleen M ; Conn, P. Jeffrey ; Emmitte, Kyle A ; Lindsley, Craig W

ACS medicinal chemistry letters, 2017-09, Vol.8 (9), p.919-924 [Periódico revisado por pares]

American Chemical Society

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8
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M 4 Muscarinic Acetylcholine Receptor Antagonist
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M 4 Muscarinic Acetylcholine Receptor Antagonist
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Discovery of VU6028418: A Highly Selective and Orally Bioavailable M 4 Muscarinic Acetylcholine Receptor Antagonist

Spock, Matthew ; Carter, Trever R ; Bollinger, Katrina A ; Han, Changho ; Baker, Logan A ; Rodriguez, Alice L ; Peng, Li ; Dickerson, Jonathan W ; Qi, Aidong ; Rook, Jerri M ; O'Neill, Jordan C ; Watson, Katherine J ; Chang, Sichen ; Bridges, Thomas M ; Engers, Julie L ; Engers, Darren W ; Niswender, Colleen M ; Conn, P Jeffrey ; Lindsley, Craig W ; Bender, Aaron M

ACS medicinal chemistry letters, 2021-08, Vol.12 (8), p.1342-1349 [Periódico revisado por pares]

United States

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9
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core
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Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

Wood, Michael R. ; Noetzel, Meredith J. ; Engers, Julie L. ; Bollinger, Katrina A. ; Melancon, Bruce J. ; Tarr, James C. ; Han, Changho ; West, Mary ; Gregro, Alison R. ; Lamsal, Atin ; Chang, Sichen ; Ajmera, Sonia ; Smith, Emery ; Chase, Peter ; Hodder, Peter S. ; Bubser, Michael ; Jones, Carrie K. ; Hopkins, Corey R. ; Emmitte, Kyle A. ; Niswender, Colleen M. ; Wood, Michael W. ; Duggan, Mark E. ; Conn, P. Jeffrey ; Bridges, Thomas M. ; Lindsley, Craig W.

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (13), p.3029-3033 [Periódico revisado por pares]

England: Elsevier Ltd

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10
SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs
SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs
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SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs

Chopko, Trevor C. ; Han, Changho ; Gregro, Alison R. ; Engers, Darren W. ; Felts, Andrew S. ; Poslusney, Mike S. ; Bollinger, Katrina A. ; Morrison, Ryan D. ; Bubser, Michael ; Lamsal, Atin ; Luscombe, Vincent B. ; Cho, Hyekyung P. ; Schnetz-Boutaud, Nathalie C. ; Rodriguez, Alice L. ; Chang, Sichen ; Daniels, J. Scott ; Stec, Donald F. ; Niswender, Colleen M. ; Jones, Carrie K. ; Wood, Michael R. ; Wood, Michael W. ; Duggan, Mark E. ; Brandon, Nicholas J. ; Conn, P. Jeffrey ; Bridges, Thomas M. ; Lindsley, Craig W. ; Melancon, Bruce J.

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2224-2228 [Periódico revisado por pares]

Elsevier Ltd

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