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Practical guidance for planning resources required to support publicly-funded adaptive clinical trials
Practical guidance for planning resources required to support publicly-funded adaptive clinical trials
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Practical guidance for planning resources required to support publicly-funded adaptive clinical trials

Wason, James M. S ; Dimairo, Munyaradzi ; Biggs, Katie ; Bowden, Sarah ; Brown, Julia ; Flight, Laura ; Hall, Jamie ; Jaki, Thomas ; Lowe, Rachel ; Pallmann, Philip ; Pilling, Mark A ; Snowdon, Claire ; Sydes, Matthew R ; Villar, Sofía S ; Weir, Christopher J ; Wilson, Nina ; Yap, Christina ; Hancock, Helen ; Maier, Rebecca

BioMed Central 2022

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AGILE-ACCORD: A Randomized, Multicentre, Seamless, Adaptive Phase I/II Platform Study to Determine the Optimal Dose, Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trial
AGILE-ACCORD: A Randomized, Multicentre, Seamless, Adaptive Phase I/II Platform Study to Determine the Optimal Dose, Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trial
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AGILE-ACCORD: A Randomized, Multicentre, Seamless, Adaptive Phase I/II Platform Study to Determine the Optimal Dose, Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trial

Griffiths, Gareth ; Fitzgerald, Richard ; Jaki, Thomas ; Corkhill, Andrea ; Marwood, Ellice ; Reynolds, Helen ; Stanton, Louise ; Ewings, Sean ; Condie, Susannah ; Wrixon, Emma ; Norton, Andrea ; Radford, Mike ; Yeats, Sara ; Robertson, Jane ; Darby-Dowman, Rachel ; Walker, Lauren ; Khoo, Saye ; UK NIHR community

Trials 2020

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3
When to keep it simple - adaptive designs are not always useful
When to keep it simple - adaptive designs are not always useful
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When to keep it simple - adaptive designs are not always useful

Wason, James MS ; Brocklehurst, Peter ; Yap, Christina

Springer Science and Business Media LLC 2019

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Placebo-Controlled Trials, Ethics of
Placebo-Controlled Trials, Ethics of
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Placebo-Controlled Trials, Ethics of

van der Graaf, R ; Rid, Annette

2015

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5
A phase 2a proof of concept clinical trial to evaluate ZPL-3893787 (ZPL-389) a potent, oral histamine H4, receptor antagonist for the treatment of moderate to severe atopic dermatitis (AD) in adults
A phase 2a proof of concept clinical trial to evaluate ZPL-3893787 (ZPL-389) a potent, oral histamine H4, receptor antagonist for the treatment of moderate to severe atopic dermatitis (AD) in adults
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A phase 2a proof of concept clinical trial to evaluate ZPL-3893787 (ZPL-389) a potent, oral histamine H4, receptor antagonist for the treatment of moderate to severe atopic dermatitis (AD) in adults

Werfel, T. ; Lynch, V. ; Asher, A. ; Tsianakas, A. ; Gupta, B. ; Sarmiento, R. ; Ploszczuk, A. ; Majorek-Olechowska, B. ; Cimoszko, B. ; NIKKELS, Arjen ; Hofman, T. ; Staubach, P. ; Breuer, K. ; Gawlik, A. ; Buczylko, K. ; Morren, MA ; Layton, G. ; Yeadon, M. ; Whitlock, L. ; Purkins, L. ; Liu, W.

Blackwell 2016

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6
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants
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Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants

Monteil, Vanessa ; Eaton, Brett ; Postnikova, Elena ; Murphy, Michael ; Braunsfeld, Benedict ; Crozier, Ian ; Kricek, Franz ; Niederhofer, Janine ; Schwarzbock, Alice ; Breid, Helene ; Devignot, Stephanie ; Klingstrom, Jonas ; Thalin, Charlotte ; Kellner, Max J ; Christ, Wanda ; Havervall, Sebastian ; Mereiter, Stefan ; Knapp, Sylvia ; Jimenez, Anna Sanchez ; Bugajska-Schretter, Agnes ; Dohnal, Alexander ; Ruf, Christine ; Gugenberger, Romana ; Hagelkruys, Astrid ; Montserrat, Nuria ; Kozieradzki, Ivona ; Ali, Omar Hasan ; Stadlmann, Johannes ; Holbrook, Michael R ; Schmaljohn, Connie ; Oostenbrink, Chris ; Shoemaker, Robert H ; Mirazimi, Ali ; Wirnsberger, Gerald ; Penninger, Josef M

EMBO Press 2022

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7
Mutations in the second cytoplasmic loop of CFTR suggest distinct mode of action between potentiators VX-770 and glpg1837
Mutations in the second cytoplasmic loop of CFTR suggest distinct mode of action between potentiators VX-770 and glpg1837
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Mutations in the second cytoplasmic loop of CFTR suggest distinct mode of action between potentiators VX-770 and glpg1837

Mijnders, M ; Musch, S ; Peters, F ; Conrath, K ; Braakman, I ; Kleizen, Bertrand

2017

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8
Data driven regulatory science
Data driven regulatory science
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Data driven regulatory science

De Bruin, Marie L ; Ampadu, Haggar H ; Hoekman, Jarno ; Kurz, Xavier ; Leufkens, Hubert G.M ; Sekine, Shohko ; Pan, Gerald Dal

2015

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9
Embedding Patient Input in Outcome Measures for Long‐Term Disease‐Modifying Parkinson Disease Trials
Embedding Patient Input in Outcome Measures for Long‐Term Disease‐Modifying Parkinson Disease Trials
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Embedding Patient Input in Outcome Measures for Long‐Term Disease‐Modifying Parkinson Disease Trials

Gonzalez‐Robles, Cristina ; Bartlett, Michèle ; Burnell, Matthew ; Clarke, Caroline S ; Haar, Shlomi ; Hu, Michele T ; Huxford, Brook ; Jha, Ashwani ; Lawton, Michael ; Noyce, Alastair ; Piccini, Paola ; Pushparatnam, Kuhan ; Rochester, Lynn ; Siu, Carroll ; van Wamelen, Daniel ; Williams‐Gray, Caroline H ; Zeissler, Marie‐Louise ; Zetterberg, Henrik ; Carroll, Camille B ; Foltynie, Thomas ; Weil, Rimona S ; Schrag, Anette ; the EJS ACT‐PD Consortium

Movement Disorders 2023

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10
Quantifying the impact of the COVID-19 pandemic on clinical trial screening rates over time in 37 countries
Quantifying the impact of the COVID-19 pandemic on clinical trial screening rates over time in 37 countries
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Quantifying the impact of the COVID-19 pandemic on clinical trial screening rates over time in 37 countries

McDonald, Kelsey ; Seltzer, Earl ; Lu, Mary ; Gaisenband, Stefan Diaz ; Fletcher, Cassandra ; McLeroth, Patrick ; Saini, Kamal S

BioMed Central 2023

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