A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site

Holloway, M. Katharine ; Wai, Jenny M ; Halgren, Thomas A ; Fitzgerald, Paula M. D ; Vacca, Joseph P ; Dorsey, Bruce D ; Levin, Rhonda B ; Thompson, Wayne J ; Chen, L. Jenny

Washington, DC: American Chemical Society

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Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor N-(9-Hydroxy-9-fluorenecarboxy)prolyl trans-4-Aminocyclohexylmethyl Amide (L-372,460):  Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support

Brady, Stephen F ; Stauffer, Kenneth J ; Lumma, William C ; Smith, Graham M ; Ramjit, Harri G ; Lewis, S. Dale ; Lucas, Bobby J ; Gardell, Steven J ; Lyle, Elizabeth A ; Appleby, Sandra D ; Cook, Jacquelynn J ; Holahan, Marie A ; Stranieri, Maria T ; Lynch, Joseph J ; Lin, Jiunn H ; Chen, I.-Wu ; Vastag, Kari ; Naylor-Olsen, Adel M ; Vacca, Joseph P

Washington, DC: American Chemical Society

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Pseudopeptide inhibitors of Ras farnesyl-protein transferase

Graham, S L ; deSolms, S J ; Giuliani, E A ; Kohl, N E ; Mosser, S D ; Oliff, A I ; Pompliano, D L ; Rands, E ; Breslin, M J ; Deana, A A

United States

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4-Hydroxy-5,6-dihydropyrones. 2. Potent Non-Peptide Inhibitors of HIV Protease

Tait, Bradley D ; Hagen, Susan ; Domagala, John ; Ellsworth, Edmund L ; Gajda, Christopher ; Hamilton, Harriet W ; Vara Prasad, J. V. N ; Ferguson, Donna ; Graham, Neil ; Hupe, Donald ; Nouhan, Carolyn ; Tummino, Peter J ; Humblet, Christine ; Lunney, Elizabeth A ; Pavlovsky, Alexander ; Rubin, John ; Gracheck, Stephen J ; Baldwin, Eric T ; Bhat, T. N ; Erickson, John W ; Gulnik, Sergei V ; Liu, Beishan

Washington, DC: American Chemical Society

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N-Arylalkyl Pseudopeptide Inhibitors of Farnesyltransferase

deSolms, S. Jane ; Giuliani, Elizabeth A ; Graham, Samuel L ; Koblan, Kenneth S ; Kohl, Nancy E ; Mosser, Scott D ; Oliff, Allen I ; Pompliano, David L ; Rands, Elaine ; Scholz, Thomas H ; Wiscount, Catherine M ; Gibbs, Jackson B ; Smith, Robert L

Washington, DC: American Chemical Society

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Design, Synthesis, and Pharmacological Evaluation of Conformationally Constrained Analogues of N,N‘-Diaryl- and N-Aryl-N-aralkylguanidines as Potent Inhibitors of Neuronal Na+ Channels

Maillard, Michel C ; Perlman, Michael E ; Amitay, Oved ; Baxter, Deborah ; Berlove, David ; Connaughton, Sonia ; Fischer, James B ; Guo, Jun Qing ; Hu, Lain-Yen ; McBurney, Robert N ; Nagy, Peter I ; Subbarao, Katragadda ; Yost, Elizabeth A ; Zhang, Lu ; Durant, Graham J

Washington, DC: American Chemical Society

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Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors

Street, Leslie J ; Baker, Raymond ; Book, Tracey ; Kneen, Clare O ; MacLeod, Angus M ; Merchant, Kevin J ; Showell, Graham A ; Saunders, John ; Herbert, Richard H

Washington, DC: American Chemical Society

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Nonpeptide Bradykinin B 2 Receptor Antagonists: Conversion of Rodent-Selective Bradyzide Analogues into Potent, Orally-Active Human Bradykinin B 2 Receptor Antagonists

Dziadulewicz, Edward K. ; Ritchie, Timothy J. ; Hallett, Allan ; Snell, Christopher R. ; Davies, John W. ; Wrigglesworth, Roger ; Dunstan, Andrew R. ; Bloomfield, Graham C. ; Drake, Gillian S. ; McIntyre, Peter ; Brown, Michael C. ; Burgess, Gillian M. ; Lee, Wai ; Davis, Clare ; Yaqoob, Mohammed ; Phagoo, Steve B. ; Phillips, Elsa ; Perkins, Martin N. ; Campbell, Elizabeth A. ; Davis, Andrew J. ; Rang, Humphrey P.

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Pseudodipeptide Inhibitors of Protein Farnesyltransferase

deSolms, S. Jane ; Deana, Albert A ; Giuliani, Elizabeth A ; Graham, Samuel L ; Kohl, Nancy E ; Mosser, Scott D ; Oliff, Allen I ; Pompliano, David L ; Rands, Elaine

Washington, DC: American Chemical Society

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1-(2-Nitrophenyl)thiosemicarbazides:  A Novel Class of Potent, Orally Active Non-Peptide Antagonist for the Bradykinin B 2 Receptor

Dziadulewicz, Edward K. ; Ritchie, Timothy J. ; Hallett, Allan ; Snell, Christopher R. ; Ko, Soo Y. ; Wrigglesworth, Roger ; Hughes, Glyn A. ; Dunstan, Andrew R. ; Bloomfield, Graham C. ; Drake, Gillian S. ; Brown, Michael C. ; Lee, Wai ; Burgess, Gillian M. ; Davis, Clare ; Yaqoob, Mohammed ; Perkins, Martin N. ; Campbell, Elizabeth A. ; Davis, Andrew J. ; Rang, Humphrey P.

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