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Material Type: Artigo
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Rynaxypyr™: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activatorLahm, George P. ; Stevenson, Thomas M. ; Selby, Thomas P. ; Freudenberger, John H. ; Cordova, Daniel ; Flexner, Lindsey ; Bellin, Cheryl A. ; Dubas, Christine M. ; Smith, Ben K. ; Hughes, Kenneth A. ; Hollingshaus, J. Gary ; Clark, Christopher E. ; Benner, Eric A.Bioorganic & medicinal chemistry, 2007-11, Vol.17 (22), p.6274-6279 [Periódico revisado por pares]Oxford: Elsevier LtdTexto completo disponível |
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Material Type: Artigo
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The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin KGauthier, Jacques Yves ; Chauret, Nathalie ; Cromlish, Wanda ; Desmarais, Sylvie ; Duong, Le T. ; Falgueyret, Jean-Pierre ; Kimmel, Donald B. ; Lamontagne, Sonia ; Léger, Serge ; LeRiche, Tammy ; Li, Chun Sing ; Massé, Frédéric ; McKay, Daniel J. ; Nicoll-Griffith, Deborah A. ; Oballa, Renata M. ; Palmer, James T. ; Percival, M. David ; Riendeau, Denis ; Robichaud, Joel ; Rodan, Gideon A. ; Rodan, Sevgi B. ; Seto, Carmai ; Thérien, Michel ; Truong, Vouy-Linh ; Venuti, Michael C. ; Wesolowski, Gregg ; Young, Robert N. ; Zamboni, Robert ; Black, W. CameronBioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.923-928 [Periódico revisado por pares]Oxford: Elsevier LtdTexto completo disponível |
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Material Type: Artigo
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Physiochemical drug properties associated with in vivo toxicological outcomesHughes, Jason D. ; Blagg, Julian ; Price, David A. ; Bailey, Simon ; DeCrescenzo, Gary A. ; Devraj, Rajesh V. ; Ellsworth, Edmund ; Fobian, Yvette M. ; Gibbs, Michael E. ; Gilles, Richard W. ; Greene, Nigel ; Huang, Enoch ; Krieger-Burke, Teresa ; Loesel, Jens ; Wager, Travis ; Whiteley, Larry ; Zhang, YaoBioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4872-4875 [Periódico revisado por pares]Oxford: Elsevier LtdTexto completo disponível |
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Material Type: Artigo
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Glycosidic carbonic anhydrase IX inhibitors: A sweet approach against cancerWinum, Jean-Yves ; Colinas, Pedro A. ; Supuran, Claudiu T.Bioorganic & medicinal chemistry, 2013-03, Vol.21 (6), p.1419-1426 [Periódico revisado por pares]England: Elsevier LtdTexto completo disponível |
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Material Type: Artigo
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Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitorsCumming, J.N. ; Le, T.X. ; Babu, S. ; Carroll, C. ; Chen, X. ; Favreau, L. ; Gaspari, P. ; Guo, T. ; Hobbs, D.W. ; Huang, Y. ; Iserloh, U. ; Kennedy, M.E. ; Kuvelkar, R. ; Li, G. ; Lowrie, J. ; McHugh, N.A. ; Ozgur, L. ; Pan, J. ; Parker, E.M. ; Saionz, K. ; Stamford, A.W. ; Strickland, C. ; Tadesse, D. ; Voigt, J. ; Wang, L. ; Wu, Y. ; Zhang, L. ; Zhang, Q.Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3236-3241 [Periódico revisado por pares]Oxford: Elsevier LtdTexto completo disponível |
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Material Type: Artigo
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Recent advances in the biology and chemistry of the flavaglinesRibeiro, Nigel ; Thuaud, Frédéric ; Nebigil, Canan ; Désaubry, LaurentBioorganic & medicinal chemistry, 2012-03, Vol.20 (6), p.1857-1864 [Periódico revisado por pares]England: Elsevier LtdTexto completo disponível |
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Material Type: Artigo
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Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft modelBilodeau, Mark T. ; Balitza, Adrienne E. ; Hoffman, Jacob M. ; Manley, Peter J. ; Barnett, Stanley F. ; Defeo-Jones, Deborah ; Haskell, Kathleen ; Jones, Raymond E. ; Leander, Karen ; Robinson, Ronald G. ; Smith, Anthony M. ; Huber, Hans E. ; Hartman, George D.Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3178-3182 [Periódico revisado por pares]England: Elsevier LtdTexto completo disponível |
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Material Type: Artigo
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Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2) : Structure-activity relationships and strategies for the elimination of reactive metabolite formationWALKER, Daniel P ; BI, F. Christopher ; MCGLYNN, Molly A ; OLIVER, Robert ; DUNN, Matthew ; LI, Jian-Cheng ; RICHTER, Daniel T ; COOPER, Beth A ; KATH, John C ; HULFORD, Catherine A ; AUTRY, Christopher L ; LUZZIO, Michael J ; KALGUTKAR, Amit S ; UNG, Ethan J ; ROBERTS, W. Gregory ; BONNETTE, Peter C ; BUCKBINDER, Leonard ; MISTRY, Anil ; GRIFFOR, Matthew C ; HAN, Seungil ; GUZMAN-PEREZ, Angel ; BAUMAN, Jonathan N ; ZHAO, Sabrina X ; SOGLIA, John R ; ASPNES, Gary E ; KUNG, Daniel W ; KLUG-MCLEOD, Jacquelyn ; ZAWISTOSKI, Michael PBioorganic & medicinal chemistry, 2008-12, Vol.18 (23), p.6071-6077 [Periódico revisado por pares]Amsterdam: ElsevierTexto completo disponível |
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Material Type: Artigo
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Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivativesCao, Rihui ; Yi, Wei ; Wu, Qifeng ; Guan, Xiangdong ; Feng, Manxiu ; Ma, Chunming ; Chen, Zhiyong ; Song, Huacan ; Peng, WenlieBioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6558-6561 [Periódico revisado por pares]England: Elsevier LtdTexto completo disponível |
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Material Type: Artigo
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Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350Raboisson, Pierre ; de Kock, Herman ; Rosenquist, Åsa ; Nilsson, Magnus ; Salvador-Oden, Lourdes ; Lin, Tse-I ; Roue, Natalie ; Ivanov, Vladimir ; Wähling, Horst ; Wickström, Kristina ; Hamelink, Elizabeth ; Edlund, Michael ; Vrang, Lotta ; Vendeville, Sandrine ; Van de Vreken, Wim ; McGowan, David ; Tahri, Abdellah ; Hu, Lili ; Boutton, Carlo ; Lenz, Oliver ; Delouvroy, Frederic ; Pille, Geert ; Surleraux, Dominique ; Wigerinck, Piet ; Samuelsson, Bertil ; Simmen, KennethBioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4853-4858 [Periódico revisado por pares]Oxford: Elsevier LtdTexto completo disponível |