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Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy
Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy
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Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy

Murakami, Eisuke ; Wang, Ting ; Park, Yeojin ; Hao, Jia ; Lepist, Eve-Irene ; Babusis, Darius ; Ray, Adrian S

Antimicrobial agents and chemotherapy, 2015-06, Vol.59 (6), p.3563-3569 [Periódico revisado por pares]

United States: American Society for Microbiology

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Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
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Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Axten, Jeffrey M ; Medina, Jesús R ; Feng, Yanhong ; Shu, Arthur ; Romeril, Stuart P ; Grant, Seth W ; Li, William Hoi Hong ; Heerding, Dirk A ; Minthorn, Elisabeth ; Mencken, Thomas ; Atkins, Charity ; Liu, Qi ; Rabindran, Sridhar ; Kumar, Rakesh ; Hong, Xuan ; Goetz, Aaron ; Stanley, Thomas ; Taylor, J. David ; Sigethy, Scott D ; Tomberlin, Ginger H ; Hassell, Annie M ; Kahler, Kirsten M ; Shewchuk, Lisa M ; Gampe, Robert T

Journal of medicinal chemistry, 2012-08, Vol.55 (16), p.7193-7207 [Periódico revisado por pares]

United States: American Chemical Society

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3
Antiviral Activity, Safety, and Pharmacokinetics/Pharmacodynamics of Tenofovir Alafenamide as 10-Day Monotherapy in HIV-1–Positive Adults
Antiviral Activity, Safety, and Pharmacokinetics/Pharmacodynamics of Tenofovir Alafenamide as 10-Day Monotherapy in HIV-1–Positive Adults
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Antiviral Activity, Safety, and Pharmacokinetics/Pharmacodynamics of Tenofovir Alafenamide as 10-Day Monotherapy in HIV-1–Positive Adults

Ruane, Peter J ; DeJesus, Edwin ; Berger, Daniel ; Markowitz, Martin ; Bredeek, U Fritz ; Callebaut, Christian ; Zhong, Lijie ; Ramanathan, Srini ; S. Rhee, Martin ; Fordyce, Marshall W ; Yale, Kitty

Journal of acquired immune deficiency syndromes (1999), 2013-08, Vol.63 (4), p.449-455 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins, Inc

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4
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice
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Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

Moreno, Julie A ; Halliday, Mark ; Molloy, Colin ; Radford, Helois ; Verity, Nicholas ; Axten, Jeffrey M ; Ortori, Catharine A ; Willis, Anne E ; Fischer, Peter M ; Barrett, David A ; Mallucci, Giovanna R

Science translational medicine, 2013-10, Vol.5 (206), p.206ra138 [Periódico revisado por pares]

United States

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5
Autophagy protects auditory hair cells against neomycin-induced damage
Autophagy protects auditory hair cells against neomycin-induced damage
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Autophagy protects auditory hair cells against neomycin-induced damage

He, Zuhong ; Guo, Lingna ; Shu, Yilai ; Fang, Qiaojun ; Zhou, Han ; Liu, Yongze ; Liu, Dingding ; Lu, Ling ; Zhang, Xiaoli ; Ding, Xiaoqiong ; Liu, Dong ; Tang, Mingliang ; Kong, Weijia ; Sha, Suhua ; Li, Huawei ; Gao, Xia ; Chai, Renjie

Autophagy, 2017-11, Vol.13 (11), p.1884-1904 [Periódico revisado por pares]

United States: Taylor & Francis

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6
Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK‐dependent autophagy
Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK‐dependent autophagy
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Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK‐dependent autophagy

Jiang, Teng ; Yu, Jin‐Tai ; Zhu, Xi‐Chen ; Wang, Hui‐Fu ; Tan, Meng‐Shan ; Cao, Lei ; Zhang, Qiao‐Quan ; Gao, Li ; Shi, Jian‐Quan ; Zhang, Ying‐Dong ; Tan, Lan

British journal of pharmacology, 2014-07, Vol.171 (13), p.3146-3157 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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7
Phase I/II study of the pharmacokinetics, safety and antiretroviral activity of tenofovir alafenamide, a new prodrug of the HIV reverse transcriptase inhibitor tenofovir, in HIV-infected adults
Phase I/II study of the pharmacokinetics, safety and antiretroviral activity of tenofovir alafenamide, a new prodrug of the HIV reverse transcriptase inhibitor tenofovir, in HIV-infected adults
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Phase I/II study of the pharmacokinetics, safety and antiretroviral activity of tenofovir alafenamide, a new prodrug of the HIV reverse transcriptase inhibitor tenofovir, in HIV-infected adults

Markowitz, Martin ; Zolopa, Andrew ; Squires, Kathleen ; Ruane, Peter ; Coakley, Dion ; Kearney, Brian ; Zhong, Lijie ; Wulfsohn, Michael ; Miller, Michael D ; Lee, William A

Journal of antimicrobial chemotherapy, 2014-05, Vol.69 (5), p.1362-1369 [Periódico revisado por pares]

England: Oxford Publishing Limited (England)

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8
Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors
Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors
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Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors

Wang, Eric ; Mi, Xiaoli ; Thompson, Meghan C ; Montoya, Skye ; Notti, Ryan Q ; Afaghani, Jumana ; Durham, Benjamin H ; Penson, Alex ; Witkowski, Matthew T ; Lu, Sydney X ; Bourcier, Jessie ; Hogg, Simon J ; Erickson, Caroline ; Cui, Dan ; Cho, Hana ; Singer, Michael ; Totiger, Tulasigeri M ; Chaudhry, Sana ; Geyer, Mark ; Alencar, Alvaro ; Linley, Adam J ; Palomba, M. Lia ; Coombs, Catherine C ; Park, Jae H ; Zelenetz, Andrew ; Roeker, Lindsey ; Rosendahl, Mary ; Tsai, Donald E ; Ebata, Kevin ; Brandhuber, Barbara ; Hyman, David M ; Aifantis, Iannis ; Mato, Anthony ; Taylor, Justin ; Abdel-Wahab, Omar

The New England journal of medicine, 2022-02, Vol.386 (8), p.735-743 [Periódico revisado por pares]

United States: Massachusetts Medical Society

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9
An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral
An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral
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An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral

Julander, Justin G. ; Demarest, James F. ; Taylor, Ray ; Gowen, Brian B. ; Walling, Dennis M. ; Mathis, Amanda ; Babu, Y.S.

Antiviral research, 2021-11, Vol.195, p.105180-105180, Article 105180 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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10
Immunomodulatory Mechanism of Acyclic Nucleoside Phosphates in Treatment of Hepatitis B Virus Infection
Immunomodulatory Mechanism of Acyclic Nucleoside Phosphates in Treatment of Hepatitis B Virus Infection
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Immunomodulatory Mechanism of Acyclic Nucleoside Phosphates in Treatment of Hepatitis B Virus Infection

Murata, Kazumoto ; Tsukuda, Senko ; Suizu, Futoshi ; Kimura, Akihiro ; Sugiyama, Masaya ; Watashi, Koichi ; Noguchi, Masayuki ; Mizokami, Masashi

Hepatology (Baltimore, Md.), 2020-05, Vol.71 (5), p.1533-1545 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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