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Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
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Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides

Becker, Sidney ; Feldmann, Jonas ; Wiedemann, Stefan ; Okamura, Hidenori ; Schneider, Christina ; Iwan, Katharina ; Crisp, Antony ; Rossa, Martin ; Amatov, Tynchtyk ; Carell, Thomas

Science (American Association for the Advancement of Science), 2019-10, Vol.366 (6461), p.76-82 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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2
A Sustainable Multicomponent Pyrimidine Synthesis
A Sustainable Multicomponent Pyrimidine Synthesis
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A Sustainable Multicomponent Pyrimidine Synthesis

Deibl, Nicklas ; Ament, Kevin ; Kempe, Rhett

Journal of the American Chemical Society, 2015-10, Vol.137 (40), p.12804-12807 [Periódico revisado por pares]

United States: American Chemical Society

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3
Synthesis of Pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine Derivatives for Antiviral Evaluation
Synthesis of Pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine Derivatives for Antiviral Evaluation
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Synthesis of Pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine Derivatives for Antiviral Evaluation

Shamroukh, Ahmed H. ; Zaki, Magdi E. A. ; Morsy, Eman M. H. ; Abdel-Motti, Faiza M. ; Abdel-Megeid, Farouk M. E.

Archiv der Pharmazie (Weinheim), 2007-05, Vol.340 (5), p.236-243 [Periódico revisado por pares]

Weinheim: WILEY-VCH Verlag

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4
Roles of Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Anticancer Agents
Roles of Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Anticancer Agents
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Roles of Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Anticancer Agents

Prachayasittikul, Supaluk ; Pingaew, Ratchanok ; Worachartcheewan, Apilak ; Sinthupoom, Nujarin ; Prachayasittikul, Veda ; Ruchirawat, Somsak ; Prachayasittikul, Virapong

Mini reviews in medicinal chemistry, 2017-01, Vol.17 (10), p.869-901 [Periódico revisado por pares]

Netherlands: Bentham Science Publishers Ltd

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5
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression
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Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

Zhou, Bing ; Hu, Jiantao ; Xu, Fuming ; Chen, Zhuo ; Bai, Longchuan ; Fernandez-Salas, Ester ; Lin, Mei ; Liu, Liu ; Yang, Chao-Yie ; Zhao, Yujun ; McEachern, Donna ; Przybranowski, Sally ; Wen, Bo ; Sun, Duxin ; Wang, Shaomeng

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.462-481 [Periódico revisado por pares]

United States: American Chemical Society

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6
Fluorescent nucleobases as tools for studying DNA and RNA
Fluorescent nucleobases as tools for studying DNA and RNA
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Fluorescent nucleobases as tools for studying DNA and RNA

Xu, Wang ; Chan, Ke Min ; Kool, Eric T

Nature chemistry, 2017-11, Vol.9 (11), p.1043-1055 [Periódico revisado por pares]

England: Nature Publishing Group

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7
Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold
Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold
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Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold

Arias-Gómez, Andres ; Godoy, Andrés ; Portilla, Jaime

Molecules (Basel, Switzerland), 2021-05, Vol.26 (9), p.2708 [Periódico revisado por pares]

Switzerland: MDPI AG

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8
Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
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Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Axten, Jeffrey M ; Medina, Jesús R ; Feng, Yanhong ; Shu, Arthur ; Romeril, Stuart P ; Grant, Seth W ; Li, William Hoi Hong ; Heerding, Dirk A ; Minthorn, Elisabeth ; Mencken, Thomas ; Atkins, Charity ; Liu, Qi ; Rabindran, Sridhar ; Kumar, Rakesh ; Hong, Xuan ; Goetz, Aaron ; Stanley, Thomas ; Taylor, J. David ; Sigethy, Scott D ; Tomberlin, Ginger H ; Hassell, Annie M ; Kahler, Kirsten M ; Shewchuk, Lisa M ; Gampe, Robert T

Journal of medicinal chemistry, 2012-08, Vol.55 (16), p.7193-7207 [Periódico revisado por pares]

United States: American Chemical Society

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9
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
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Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Garcia Fortanet, Jorge ; Chen, Christine Hiu-Tung ; Chen, Ying-Nan P ; Chen, Zhouliang ; Deng, Zhan ; Firestone, Brant ; Fekkes, Peter ; Fodor, Michelle ; Fortin, Pascal D ; Fridrich, Cary ; Grunenfelder, Denise ; Ho, Samuel ; Kang, Zhao B ; Karki, Rajesh ; Kato, Mitsunori ; Keen, Nick ; LaBonte, Laura R ; Larrow, Jay ; Lenoir, Francois ; Liu, Gang ; Liu, Shumei ; Lombardo, Franco ; Majumdar, Dyuti ; Meyer, Matthew J ; Palermo, Mark ; Perez, Lawrence ; Pu, Minying ; Ramsey, Timothy ; Sellers, William R ; Shultz, Michael D ; Stams, Travis ; Towler, Christopher ; Wang, Ping ; Williams, Sarah L ; Zhang, Ji-Hu ; LaMarche, Matthew J

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7773-7782 [Periódico revisado por pares]

United States: American Chemical Society

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10
Biologically Driven Synthesis of Pyrazolo[3,4‑d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies
Biologically Driven Synthesis of Pyrazolo[3,4‑d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies
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Biologically Driven Synthesis of Pyrazolo[3,4‑d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies

Schenone, Silvia ; Radi, Marco ; Musumeci, Francesca ; Brullo, Chiara ; Botta, Maurizio

Chemical reviews, 2014-07, Vol.114 (14), p.7189-7238 [Periódico revisado por pares]

United States: American Chemical Society

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