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Synthesis of Pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine Derivatives for Antiviral Evaluation
Synthesis of Pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine Derivatives for Antiviral Evaluation
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Synthesis of Pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine Derivatives for Antiviral Evaluation

Shamroukh, Ahmed H. ; Zaki, Magdi E. A. ; Morsy, Eman M. H. ; Abdel-Motti, Faiza M. ; Abdel-Megeid, Farouk M. E.

Archiv der Pharmazie (Weinheim), 2007-05, Vol.340 (5), p.236-243 [Periódico revisado por pares]

Weinheim: WILEY-VCH Verlag

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2
Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
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Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Axten, Jeffrey M ; Medina, Jesús R ; Feng, Yanhong ; Shu, Arthur ; Romeril, Stuart P ; Grant, Seth W ; Li, William Hoi Hong ; Heerding, Dirk A ; Minthorn, Elisabeth ; Mencken, Thomas ; Atkins, Charity ; Liu, Qi ; Rabindran, Sridhar ; Kumar, Rakesh ; Hong, Xuan ; Goetz, Aaron ; Stanley, Thomas ; Taylor, J. David ; Sigethy, Scott D ; Tomberlin, Ginger H ; Hassell, Annie M ; Kahler, Kirsten M ; Shewchuk, Lisa M ; Gampe, Robert T

Journal of medicinal chemistry, 2012-08, Vol.55 (16), p.7193-7207 [Periódico revisado por pares]

United States: American Chemical Society

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3
Efficient Preparation of 2,4-Diaminopyrimidine Nucleosides: Total Synthesis of Lysidine and Agmatidine
Efficient Preparation of 2,4-Diaminopyrimidine Nucleosides: Total Synthesis of Lysidine and Agmatidine
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Efficient Preparation of 2,4-Diaminopyrimidine Nucleosides: Total Synthesis of Lysidine and Agmatidine

Kopina, Brett J ; Lauhon, Charles T

Organic letters, 2012-08, Vol.14 (16), p.4118-4121 [Periódico revisado por pares]

United States: American Chemical Society

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4
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential
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Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

Coteron, Jose M ; Marco, María ; Esquivias, Jorge ; Deng, Xiaoyi ; White, Karen L ; White, John ; Koltun, Maria ; El Mazouni, Farah ; Kokkonda, Sreekanth ; Katneni, Kasiram ; Bhamidipati, Ravi ; Shackleford, David M ; Angulo-Barturen, Iñigo ; Ferrer, Santiago B ; Jiménez-Díaz, María Belén ; Gamo, Francisco-Javier ; Goldsmith, Elizabeth J ; Charman, William N ; Bathurst, Ian ; Floyd, David ; Matthews, David ; Burrows, Jeremy N ; Rathod, Pradipsinh K ; Charman, Susan A ; Phillips, Margaret A

Journal of medicinal chemistry, 2011-08, Vol.54 (15), p.5540-5561 [Periódico revisado por pares]

United States: American Chemical Society

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5
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions
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Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

Sutherland, John D ; Powner, Matthew W ; Gerland, Béatrice

Nature, 2009-05, Vol.459 (7244), p.239-242 [Periódico revisado por pares]

London: Nature Publishing Group

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6
Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase
Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase
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Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

Guagnano, Vito ; Furet, Pascal ; Spanka, Carsten ; Bordas, Vincent ; Le Douget, Mickaël ; Stamm, Christelle ; Brueggen, Josef ; Jensen, Michael R ; Schnell, Christian ; Schmid, Herbert ; Wartmann, Markus ; Berghausen, Joerg ; Drueckes, Peter ; Zimmerlin, Alfred ; Bussiere, Dirksen ; Murray, Jeremy ; Graus Porta, Diana

Journal of medicinal chemistry, 2011-10, Vol.54 (20), p.7066-7083 [Periódico revisado por pares]

United States: American Chemical Society

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7
Catalytic and Highly Regioselective Cross-Coupling of Aromatic C−H Substrates
Catalytic and Highly Regioselective Cross-Coupling of Aromatic C−H Substrates
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Catalytic and Highly Regioselective Cross-Coupling of Aromatic C−H Substrates

Hull, Kami L ; Sanford, Melanie S

Journal of the American Chemical Society, 2007-10, Vol.129 (39), p.11904-11905 [Periódico revisado por pares]

United States: American Chemical Society

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8
Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection
Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection
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Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

Flanagan, Mark E ; Blumenkopf, Todd A ; Brissette, William H ; Brown, Matthew F ; Casavant, Jeffrey M ; Shang-Poa, Chang ; Doty, Jonathan L ; Elliott, Eileen A ; Fisher, Michael B ; Hines, Michael ; Kent, Craig ; Kudlacz, Elizabeth M ; Lillie, Brett M ; Magnuson, Kelly S ; McCurdy, Sandra P ; Munchhof, Michael J ; Perry, Bret D ; Sawyer, Perry S ; Strelevitz, Timothy J ; Subramanyam, Chakrapani ; Sun, Jianmin ; Whipple, David A ; Changelian, Paul S

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8468-8484 [Periódico revisado por pares]

United States: American Chemical Society

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9
Synthesis and Antiviral Activity of the Carbocyclic Analogue of the Highly Potent and Selective Anti-VZV Bicyclo Furano Pyrimidines
Synthesis and Antiviral Activity of the Carbocyclic Analogue of the Highly Potent and Selective Anti-VZV Bicyclo Furano Pyrimidines
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Synthesis and Antiviral Activity of the Carbocyclic Analogue of the Highly Potent and Selective Anti-VZV Bicyclo Furano Pyrimidines

Migliore, Marco D ; Zonta, Nicola ; McGuigan, Christopher ; Henson, Geoffrey ; Andrei, Graciela ; Snoeck, Robert ; Balzarini, Jan

Journal of medicinal chemistry, 2007-12, Vol.50 (26), p.6485-6492 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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10
Synthesis and Antiviral Screening of Some Thieno[2,3-d]Pyrimidine Nucleosides
Synthesis and Antiviral Screening of Some Thieno[2,3-d]Pyrimidine Nucleosides
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Synthesis and Antiviral Screening of Some Thieno[2,3-d]Pyrimidine Nucleosides

Rashad, A. E. ; Ali, M. A.

Nucleosides, nucleotides & nucleic acids, 2006-01, Vol.25 (1), p.17-28 [Periódico revisado por pares]

United States: Taylor & Francis Group

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