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In vivo genome editing using Staphylococcus aureus Cas9Ran, F Ann ; Cong, Le ; Yan, Winston X ; Scott, David A ; Gootenberg, Jonathan S ; Kriz, Andrea J ; Zetsche, Bernd ; Shalem, Ophir ; Wu, Xuebing ; Makarova, Kira S ; Koonin, Eugene V ; Sharp, Phillip A ; Zhang, FengNature (London), 2015-04, Vol.520 (7546), p.186-191 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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PCSK9: A Key Modulator of Cardiovascular HealthSeidah, Nabil G ; Awan, Zuhier ; Chrétien, Michel ; Mbikay, MajambuCirculation research, 2014-03, Vol.114 (6), p.1022-1036 [Periódico revisado por pares]United States: American Heart Association, IncTexto completo disponível |
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Material Type: Artigo
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Targeting the Proprotein Convertase Subtilisin/Kexin Type 9 for the Treatment of Dyslipidemia and AtherosclerosisUrban, Daniel, MD ; Pöss, Janine, MD ; Böhm, Michael, MD ; Laufs, Ulrich, MDJournal of the American College of Cardiology, 2013-10, Vol.62 (16), p.1401-1408 [Periódico revisado por pares]New York, NY: Elsevier IncTexto completo disponível |
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Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition: A New Therapeutic Mechanism for Reducing Cardiovascular Disease RiskBergeron, Nathalie ; Phan, Binh P ; Ding, Yunchen ; Fong, Aleyna ; Krauss, Ronald MCirculation (New York, N.Y.), 2015-10, Vol.132 (17), p.1648-1666 [Periódico revisado por pares]United States: by the American College of Cardiology Foundation and the American Heart Association, IncTexto completo disponível |
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Material Type: Artigo
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The PCSK9 decadeLambert, Gilles ; Sjouke, Barbara ; Choque, Benjamin ; Kastelein, John J.P. ; Hovingh, G. KeesJournal of lipid research, 2012-12, Vol.53 (12), p.2515-2524 [Periódico revisado por pares]United States: Elsevier IncTexto completo disponível |
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Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2Ramzy, Adam ; Asadi, Ali ; Kieffer, Timothy JDiabetes (New York, N.Y.), 2020-07, Vol.69 (7), p.1451-1462 [Periódico revisado por pares]United States: American Diabetes AssociationTexto completo disponível |
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Material Type: Artigo
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A Highly Durable RNAi Therapeutic Inhibitor of PCSK9Fitzgerald, Kevin ; White, Suellen ; Borodovsky, Anna ; Bettencourt, Brian R ; Strahs, Andrew ; Clausen, Valerie ; Wijngaard, Peter ; Horton, Jay D ; Taubel, Jorg ; Brooks, Ashley ; Fernando, Chamikara ; Kauffman, Robert S ; Kallend, David ; Vaishnaw, Akshay ; Simon, AmyThe New England journal of medicine, 2017-01, Vol.376 (1), p.41-51 [Periódico revisado por pares]United States: Massachusetts Medical SocietyTexto completo disponível |
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Material Type: Artigo
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Effect of a Monoclonal Antibody to PCSK9 on LDL CholesterolStein, Evan A ; Mellis, Scott ; Yancopoulos, George D ; Stahl, Neil ; Logan, Douglas ; Smith, William B ; Lisbon, Eleanor ; Gutierrez, Maria ; Webb, Cheryle ; Wu, Richard ; Du, Yunling ; Kranz, Therese ; Gasparino, Evelyn ; Swergold, Gary DThe New England journal of medicine, 2012-03, Vol.366 (12), p.1108-1118 [Periódico revisado por pares]Waltham, MA: Massachusetts Medical SocietyTexto completo disponível |
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Material Type: Artigo
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Proprotein convertase subtilisin/kexin 9 inhibitor downregulates microRNA-130a-3p expression in hepatocytes to alleviates atherosclerosis progressionXu, Jinghan ; Zuo, Junrong ; Han, Chuyi ; Li, Tingting ; Jin, Dongxia ; Zhao, Fumei ; Cong, HongliangNaunyn-Schmiedeberg's archives of pharmacology, 2024-03, Vol.397 (3), p.1727-1736 [Periódico revisado por pares]Berlin/Heidelberg: Springer Berlin HeidelbergTexto completo disponível |
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Material Type: Artigo
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Mouse Models of Human Proprotein Convertase InsufficiencyShakya, Manita ; Lindberg, IrisEndocrine reviews, 2021-06, Vol.42 (3), p.259-294 [Periódico revisado por pares]US: Oxford University PressTexto completo disponível |