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Refinado por: assunto: Chemistry, Organic remover
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1
Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)
Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)
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Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)

Brooke, Darby G. ; van Dam, Ellen M. ; Watts, Colin K.W. ; Khoury, Amanda ; Dziadek, Marie A. ; Brooks, Hilary ; Graham, Lisa-Jane K. ; Flanagan, Jack U. ; Denny, William A.

Bioorganic & medicinal chemistry, 2014-02, Vol.22 (3), p.1029-1039 [Periódico revisado por pares]

England: Elsevier Ltd

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2
SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells
SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells
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SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells

Bonnet, Muriel ; Flanagan, Jack U. ; Chan, Denise A. ; Lai, Edwin W. ; Nguyen, Phuong ; Giaccia, Amato J. ; Hay, Michael P.

Bioorganic & medicinal chemistry, 2011-06, Vol.19 (11), p.3347-3356 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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3
Parallel discovery of selective and dual inhibitors of tryptophan dioxygenases IDO1 and TDO2 with a newly-modified enzymatic assay
Parallel discovery of selective and dual inhibitors of tryptophan dioxygenases IDO1 and TDO2 with a newly-modified enzymatic assay
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Parallel discovery of selective and dual inhibitors of tryptophan dioxygenases IDO1 and TDO2 with a newly-modified enzymatic assay

Capochiani de Iudicibus, Rossella ; Tomek, Petr ; Palmer, Brian D. ; Tijono, Sofian M. ; Flanagan, Jack U. ; Ching, Lai-Ming

Bioorganic & medicinal chemistry, 2021-06, Vol.39, p.116160-116160, Article 116160 [Periódico revisado por pares]

England: Elsevier Ltd

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4
An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay
An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay
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An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay

Stevenson, Ralph J. ; Azimi, Iman ; Flanagan, Jack U. ; Inserra, Marco ; Vetter, Irina ; Monteith, Gregory R. ; Denny, William A.

Bioorganic & medicinal chemistry, 2018-07, Vol.26 (12), p.3406-3413 [Periódico revisado por pares]

Elsevier Ltd

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5
Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay
Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay
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Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay

Azimi, Iman ; Flanagan, Jack U. ; Stevenson, Ralph J. ; Inserra, Marco ; Vetter, Irina ; Monteith, Gregory R. ; Denny, William A.

Bioorganic & medicinal chemistry, 2017-01, Vol.25 (1), p.440-449 [Periódico revisado por pares]

Elsevier Ltd

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6
Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474
Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474
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Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474

Gamage, Swarna A. ; Giddens, Anna C. ; Tsang, Kit Y. ; Flanagan, Jack U. ; Kendall, Jackie D. ; Lee, Woo-Jeong ; Baguley, Bruce C. ; Buchanan, Christina M. ; Jamieson, Stephen M.F. ; Shepherd, Peter R. ; Denny, William A. ; Rewcastle, Gordon W.

Bioorganic & medicinal chemistry, 2017-10, Vol.25 (20), p.5859-5874 [Periódico revisado por pares]

England: Elsevier Ltd

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7
Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3)
Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3)
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Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3)

Flanagan, Jack U. ; Atwell, Graham J. ; Heinrich, Daniel M. ; Brooke, Darby G. ; Silva, Shevan ; Rigoreau, Laurent J.M. ; Trivier, Elisabeth ; Turnbull, Andrew P. ; Raynham, Tony ; Jamieson, Stephen M.F. ; Denny, William A.

Bioorganic & medicinal chemistry, 2014-02, Vol.22 (3), p.967-977 [Periódico revisado por pares]

England: Elsevier Ltd

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8
Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1)
Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1)
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Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1)

Fung, Sai-Parng S. ; Wang, Haiyan ; Tomek, Petr ; Squire, Christopher J. ; Flanagan, Jack U. ; Palmer, Brian D. ; Bridewell, David J.A. ; Tijono, Sofian M. ; Jamie, Joanne F. ; Ching, Lai-Ming

Bioorganic & medicinal chemistry, 2013-12, Vol.21 (24), p.7595-7603 [Periódico revisado por pares]

England: Elsevier Ltd

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9
Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: Synthesis, biological evaluation and molecular modelling
Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: Synthesis, biological evaluation and molecular modelling
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Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: Synthesis, biological evaluation and molecular modelling

Marshall, Andrew J. ; Lill, Claire L. ; Chao, Mindy ; Kolekar, Sharada V. ; Lee, Woo-Jeong ; Marshall, Elaine S. ; Baguley, Bruce C. ; Shepherd, Peter R. ; Denny, William A. ; Flanagan, Jack U. ; Rewcastle, Gordon W.

Bioorganic & medicinal chemistry, 2015-07, Vol.23 (13), p.3796-3808 [Periódico revisado por pares]

England: Elsevier Ltd

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10
Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR
Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR
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Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR

Kendall, Jackie D. ; Giddens, Anna C. ; Tsang, Kit Yee ; Frédérick, Raphaël ; Marshall, Elaine S. ; Singh, Ripudaman ; Lill, Claire L. ; Lee, Woo-Jeong ; Kolekar, Sharada ; Chao, Mindy ; Malik, Alisha ; Yu, Shuqiao ; Chaussade, Claire ; Buchanan, Christina ; Rewcastle, Gordon W. ; Baguley, Bruce C. ; Flanagan, Jack U. ; Jamieson, Stephen M.F. ; Denny, William A. ; Shepherd, Peter R.

Bioorganic & medicinal chemistry, 2012-01, Vol.20 (1), p.58-68 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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