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1
Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK
Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK
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Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK

Tran, Khanh B ; Kolekar, Sharada ; Jabed, Anower ; Jaynes, Patrick ; Shih, Jen-Hsing ; Wang, Qian ; Flanagan, Jack U ; Rewcastle, Gordon W ; Baguley, Bruce C ; Shepherd, Peter R

BMC cancer, 2021-02, Vol.21 (1), p.136-136, Article 136 [Peer Reviewed Journal]

England: BioMed Central Ltd

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2
Inhibitors of Discoidin Domain Receptor (DDR) Kinases for Cancer and Inflammation
Inhibitors of Discoidin Domain Receptor (DDR) Kinases for Cancer and Inflammation
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Inhibitors of Discoidin Domain Receptor (DDR) Kinases for Cancer and Inflammation

Denny, William A ; Flanagan, Jack U

Biomolecules (Basel, Switzerland), 2021-11, Vol.11 (11), p.1671 [Peer Reviewed Journal]

Switzerland: MDPI AG

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3
Evaluation of Novel Inhibitors of Tryptophan Dioxygenases for Enzyme and Species Selectivity Using Engineered Tumour Cell Lines Expressing Either Murine or Human IDO1 or TDO2
Evaluation of Novel Inhibitors of Tryptophan Dioxygenases for Enzyme and Species Selectivity Using Engineered Tumour Cell Lines Expressing Either Murine or Human IDO1 or TDO2
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Evaluation of Novel Inhibitors of Tryptophan Dioxygenases for Enzyme and Species Selectivity Using Engineered Tumour Cell Lines Expressing Either Murine or Human IDO1 or TDO2

Tijono, Sofian M ; Palmer, Brian D ; Tomek, Petr ; Flanagan, Jack U ; Henare, Kimiora ; Gamage, Swarna ; Braun, Lukas ; Ching, Lai-Ming

Pharmaceuticals (Basel, Switzerland), 2022-08, Vol.15 (9), p.1090 [Peer Reviewed Journal]

Basel: MDPI AG

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4
Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3
Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3
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Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3

Flanagan, Jack U ; Yosaatmadja, Yuliana ; Teague, Rebecca M ; Chai, Matilda Z L ; Turnbull, Andrew P ; Squire, Christopher J Pastore, Annalisa

PloS one, 2012-08, Vol.7 (8), p.e43965-e43965 [Peer Reviewed Journal]

United States: Public Library of Science

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5
Evidence That GRIN2A Mutations in Melanoma Correlate with Decreased Survival
Evidence That GRIN2A Mutations in Melanoma Correlate with Decreased Survival
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Evidence That GRIN2A Mutations in Melanoma Correlate with Decreased Survival

D'mello, Stacey Ann N ; Flanagan, Jack U ; Green, Taryn N ; Leung, Euphemia Y ; Askarian-Amiri, Marjan E ; Joseph, Wayne R ; McCrystal, Michael R ; Isaacs, Richard J ; Shaw, James H F ; Furneaux, Christopher E ; During, Matthew J ; Finlay, Graeme J ; Baguley, Bruce C ; Kalev-Zylinska, Maggie L

Frontiers in oncology, 2014-01, Vol.3, p.333-333 [Peer Reviewed Journal]

Switzerland: Frontiers Media S.A

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6
Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6
Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6
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Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6

Paine, Mark J.I. ; McLaughlin, Lesley A. ; Flanagan, Jack U. ; Kemp, Carol A. ; Sutcliffe, Michael J. ; Roberts, Gordon C.K. ; Wolf, C. Roland

The Journal of biological chemistry, 2003-02, Vol.278 (6), p.4021-4027 [Peer Reviewed Journal]

United States: Elsevier Inc

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7
A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion
A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion
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A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion

Heitz, Samantha D. ; Hamelin, David J. ; Hoffmann, Reece M. ; Greenberg, Nili ; Salloum, Gilbert ; Erami, Zahra ; Khalil, Bassem D. ; Shymanets, Aliaksei ; Steidle, Elizabeth A. ; Gong, Grace Q. ; Nürnberg, Bernd ; Burke, John E. ; Flanagan, Jack U. ; Bresnick, Anne R. ; Backer, Jonathan M.

The Journal of biological chemistry, 2019-03, Vol.294 (12), p.4621-4633 [Peer Reviewed Journal]

United States: Elsevier Inc

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8
Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases?
Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases?
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Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases?

Hadler, Kieran S ; Huber, Thomas ; Cassady, A Ian ; Weber, Jane ; Robinson, Jodie ; Burrows, Allan ; Kelly, Gregory ; Guddat, Luke W ; Hume, David A ; Schenk, Gerhard ; Flanagan, Jack U

BMC research notes, 2008-09, Vol.1 (1), p.78-78 [Peer Reviewed Journal]

England: BioMed Central Ltd

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9
Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding
Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding
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Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding

McLaughlin, Lesley A ; Paine, Mark J I ; Kemp, Carol A ; Maréchal, Jean-Didier ; Flanagan, Jack U ; Ward, Clive J ; Sutcliffe, Michael J ; Roberts, Gordon C K ; Wolf, C Roland

The Journal of biological chemistry, 2005-11, Vol.280 (46), p.38617 [Peer Reviewed Journal]

United States

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10
Why Is Quinidine an Inhibitor of Cytochrome P450 2D6?
Why Is Quinidine an Inhibitor of Cytochrome P450 2D6?
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Why Is Quinidine an Inhibitor of Cytochrome P450 2D6?

McLaughlin, Lesley A. ; Paine, Mark J.I. ; Kemp, Carol A. ; Maréchal, Jean-Didier ; Flanagan, Jack U. ; Ward, Clive J. ; Sutcliffe, Michael J. ; Roberts, Gordon C.K. ; Wolf, C. Roland

The Journal of biological chemistry, 2005-11, Vol.280 (46), p.38617-38624 [Peer Reviewed Journal]

Elsevier Inc

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