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Farnesyltransferase Inhibitors in Cancer Therapy
Farnesyltransferase Inhibitors in Cancer Therapy
Material Type:
Livro 		Adicionar ao Meu Espaço

Farnesyltransferase Inhibitors in Cancer Therapy

Said M. Hamilton, Andrew Sebti Andrew D Hamilton; Said M Sebti; Andrew Hamilton

Humana Press 2001

Acesso online

2
Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours
Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours
Material Type:
Artigo 		Adicionar ao Meu Espaço

Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours

ZHANG, X ; BLASKOVICH, M. A ; FORINASH, K. D ; SEBTI, S. M

British journal of cancer, 2014-08, Vol.111 (5), p.894-902 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

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3
The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane
The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane
Material Type:
Artigo 		Adicionar ao Meu Espaço

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

Berndt, N ; Yang, H ; Trinczek, B ; Betzi, S ; Zhang, Z ; Wu, B ; Lawrence, N J ; Pellecchia, M ; Schönbrunn, E ; Cheng, J Q ; Sebti, S M

Cell death and differentiation, 2010-11, Vol.17 (11), p.1795-1804 [Periódico revisado por pares]

England: Nature Publishing Group

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4
A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1 Mek-1 Erk1 2 pathway
A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1 Mek-1 Erk1 2 pathway
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Artigo 		Adicionar ao Meu Espaço

A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1 Mek-1 Erk1 2 pathway

CARIEL, A. E ; SEBTI, S. M

Oncogene, 2007-05, Vol.26 (26), p.3777-3788 [Periódico revisado por pares]

Basingstoke: Nature Publishing

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5
Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities
Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities
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Artigo 		Adicionar ao Meu Espaço

Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities

Patel, R A ; Liu, Y ; Wang, B ; Li, R ; Sebti, S M

Oncogene, 2014-01, Vol.33 (5), p.550-555 [Periódico revisado por pares]

England: Nature Publishing Group

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6
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter
Material Type:
Artigo 		Adicionar ao Meu Espaço

Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter

DELARUE, F. L ; ADNANE, J ; CHELLAPPAN, S ; SEBTI, S. M ; JOSHI, B ; BLASKOVICH, M. A ; WANG, D.-A ; HAWKER, J ; BIZOUARN, F ; OHKANDA, J ; ZHU, K ; HAMILTON, A. D

Oncogene, 2007-02, Vol.26 (5), p.633-640 [Periódico revisado por pares]

Basingstoke: Nature Publishing

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7
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I : Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I : Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
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Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I : Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine

JIAZHI SUN ; BLASKOVICH, M. A ; KNOWLES, D ; YIMIN QIAN ; OHKANDA, J ; BAILEY, R. D ; HAMILTON, A. D ; SEBTI, S. M

Cancer research (Chicago, Ill.), 1999-10, Vol.59 (19), p.4919-4926 [Periódico revisado por pares]

Philadelphia, PA: American Association for Cancer Research

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8
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
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Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

SUN, J ; YIMIN QIAN ; HAMILTON, A. D ; SEBTI, S. M

Oncogene, 1998-03, Vol.16 (11), p.1467-1473 [Periódico revisado por pares]

Basingstoke: Nature Publishing

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9
Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues
Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues
Material Type:
Artigo 		Adicionar ao Meu Espaço

Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues

Sebti, Saïd M ; Hamilton, Andrew D

Expert opinion on investigational drugs, 2000-12, Vol.9 (12), p.2767-2782 [Periódico revisado por pares]

England: Ashley Publications Ltd

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10
The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells
The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells
Material Type:
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The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells

BOLICK, S. C. E ; LANDOWSKIL, T. H ; BOULWARE, D ; OSHIRO, M. M ; OHKANDA, J ; HAMILTON, A. D ; SEBTI, S. M ; DALTON, W. S

Leukemia, 2003-02, Vol.17 (2), p.451-457 [Periódico revisado por pares]

London: Nature Publishing

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Deste Autor:

  1. Hamilton, A
  2. Sebti, S

Neste Assunto:

  1. Science & Technology
  2. Life Sciences & Biomedicine
  3. Humans
  4. Animals
  5. Biological And Medical Sciences

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