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Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
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Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

Chen, Serene W. ; Drakulic, Srdja ; Deas, Emma ; Ouberai, Myriam ; Aprile, Francesco A. ; Arranz, Rocío ; Ness, Samuel ; Roodveldt, Cintia ; Guilliams, Tim ; De-Genst, Erwin J. ; Klenerman, David ; Wood, Nicholas W. ; Knowles, Tuomas P.J. ; Alfonso, Carlos ; Rivas, Germán ; Abramov, Andrey Y. ; Valpuesta, José María ; Dobson, Christopher M. ; Cremades, Nunilo

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (16), p.E1994-E2003 [Periódico revisado por pares]

United States: National Academy of Sciences

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2
KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity
KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity
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KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity

Dettmer, Ulf ; Newman, Andrew J. ; von Saucken, Victoria E. ; Bartels, Tim ; Selkoe, Dennis

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (31), p.9596-9601 [Periódico revisado por pares]

United States: National Academy of Sciences

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3
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
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Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

Choi, Bong-Kyu ; Choi, Mal-Gi ; Kim, Jae-Yeol ; Yang, Yoosoo ; Lai, Ying ; Kweon, Dae-Hyuk ; Lee, Nam Ki ; Shin, Yeon-Kyun

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (10), p.4087-4092 [Periódico revisado por pares]

United States: National Academy of Sciences

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4
In vivo demonstration that α-synuclein oligomers are toxic
In vivo demonstration that α-synuclein oligomers are toxic
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In vivo demonstration that α-synuclein oligomers are toxic

Winner, Beate ; Jappelli, Roberto ; Maji, Samir K ; Desplats, Paula A ; Boyer, Leah ; Aigner, Stefan ; Hetzer, Claudia ; Loher, Thomas ; Vilar, Marçal ; Campioni, Silvia ; Tzitzilonis, Christos ; Soragni, Alice ; Jessberger, Sebastian ; Mira, Helena ; Consiglio, Antonella ; Pham, Emiley ; Masliah, Eliezer ; Gage, Fred H ; Riek, Roland

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (10), p.4194-4199 [Periódico revisado por pares]

United States: National Academy of Sciences

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5
Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM
Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM
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Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM

Zhao, Kun ; Lim, Yeh-Jun ; Liu, Zhenying ; Long, Houfang ; Sun, Yunpeng ; Hu, Jin-Jian ; Zhao, Chunyu ; Tao, Youqi ; Zhang, Xing ; Li, Dan ; Li, Yan-Mei ; Liu, Cong

Proceedings of the National Academy of Sciences - PNAS, 2020-08, Vol.117 (33), p.20305-20315 [Periódico revisado por pares]

United States: National Academy of Sciences

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6
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
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A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Perni, Michele ; Galvagnion, Céline ; Maltsev, Alexander ; Meisl, Georg ; Müller, Martin B. D. ; Challa, Pavan K. ; Kirkegaard, Julius B. ; Flagmeier, Patrick ; Cohen, Samuel I. A. ; Cascella, Roberta ; Chen, Serene W. ; Limbocker, Ryan ; Sormanni, Pietro ; Heller, Gabriella T. ; Aprile, Francesco A. ; Cremades, Nunilo ; Cecchi, Cristina ; Chiti, Fabrizio ; Nollen, Ellen A. A. ; Knowles, Tuomas P. J. ; Vendruscolo, Michele ; Bax, Adriaan ; Zasloff, Michael ; Dobson, Christopher M.

Proceedings of the National Academy of Sciences - PNAS, 2017-02, Vol.114 (6), p.E1009-E1017 [Periódico revisado por pares]

United States: National Academy of Sciences

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7
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure
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The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

Boyer, David R. ; Li, Binsen ; Sun, Chuanqi ; Fan, Weijia ; Zhou, Kang ; Hughes, Michael P. ; Sawaya, Michael R. ; Jiang, Lin ; Eisenberg, David S.

Proceedings of the National Academy of Sciences - PNAS, 2020-02, Vol.117 (7), p.3592-3602 [Periódico revisado por pares]

United States: National Academy of Sciences

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8
Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein
Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein
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Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein

Wang, Wei ; Nguyen, Linh T. T. ; Burlak, Christopher ; Chegini, Fariba ; Guo, Feng ; Chataway, Tim ; Ju, Shulin ; Fisher, Oriana S. ; Miller, David W. ; Datta, Debajyoti ; Wu, Fang ; Wu, Chun-Xiang ; Landeru, Anuradha ; Wells, James A. ; Cookson, Mark R. ; Boxer, Matthew B. ; Thomas, Craig J. ; Gai, Wei Ping ; Ringe, Dagmar ; Petsko, Gregory A. ; Hoang, Quyen Q.

Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (34), p.9587-9592 [Periódico revisado por pares]

United States: National Academy of Sciences

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9
Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy
Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy
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Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy

Bassil, Fares ; Fernagut, Pierre-Olivier ; Bezard, Erwan ; Pruvost, Alain ; Leste-Lasserre, Thierry ; Hoang, Quyen Q. ; Ringe, Dagmar ; Petsko, Gregory A. ; Meissner, Wassilios G.

Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (34), p.9593-9598 [Periódico revisado por pares]

United States: National Academy of Sciences

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10
Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease
Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease
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Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease

Zhang, Shengnan ; Liu, Yu-Qing ; Jia, Chunyu ; Lim, Yeh-Jun ; Feng, Guoqin ; Xu, Enquan ; Long, Houfang ; Kimura, Yasuyoshi ; Tao, Youqi ; Zhao, Chunyu ; Wang, Chuchu ; Liu, Zhenying ; Hu, Jin-Jian ; Ma, Meng-Rong ; Liu, Zhijun ; Jiang, Lin ; Li, Dan ; Wang, Renxiao ; Dawson, Valina L ; Dawson, Ted M ; Li, Yan-Mei ; Mao, Xiaobo ; Liu, Cong

Proceedings of the National Academy of Sciences - PNAS, 2021-06, Vol.118 (26) [Periódico revisado por pares]

United States: National Academy of Sciences

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