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MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
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MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

Clabbers, Max T B ; Holmes, Susannah ; Muusse, Timothy W ; Vajjhala, Parimala R ; Thygesen, Sara J ; Malde, Alpeshkumar K ; Hunter, Dominic J B ; Croll, Tristan I ; Flueckiger, Leonie ; Nanson, Jeffrey D ; Rahaman, Md Habibur ; Aquila, Andrew ; Hunter, Mark S ; Liang, Mengning ; Yoon, Chun Hong ; Zhao, Jingjing ; Zatsepin, Nadia A ; Abbey, Brian ; Sierecki, Emma ; Gambin, Yann ; Stacey, Katryn J ; Darmanin, Connie ; Kobe, Bostjan ; Xu, Hongyi ; Ve, Thomas

Nature communications, 2021-05, Vol.12 (1), p.2578-14, Article 2578 [Revista revisada por pares]

England: Nature Publishing Group

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2
The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4
The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4
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The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4

Verstak, Brett ; Stack, Julianne ; Ve, Thomas ; Mangan, Matthew ; Hjerrild, Kathryn ; Jeon, Jannah ; Stahl, Rainer ; Latz, Eicke ; Gay, Nick ; Kobe, Bostjan ; Bowie, Andrew G. ; Mansell, Ashley

Journal of leukocyte biology, 2014-09, Vol.96 (3), p.427-436 [Revista revisada por pares]

United States: Society for Leukocyte Biology

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3
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
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Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

Valkov, Eugene ; Stamp, Anna ; DiMaio, Frank ; Baker, David ; Verstak, Brett ; Roversi, Pietro ; Kellie, Stuart ; Sweet, Matthew J ; Mansell, Ashley ; Gay, Nicholas J ; Martin, Jennifer L ; Kobe, Bostjan

Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (36), p.14879-14884 [Revista revisada por pares]

United States: National Academy of Sciences

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4
Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88
Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88
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Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88

O'Carroll, Ailís ; Chauvin, Brieuc ; Brown, James W P ; Meagher, Ava ; Coyle, Joanne ; Schill, Jurgen ; Bhumkhar, Akshay ; Hunter, Dominic J B ; Ve, Thomas ; Kobe, Bostjan ; Sierecki, Emma ; Gambin, Yann

BMC biology, 2018-12, Vol.16 (1), p.149-149, Article 149 [Revista revisada por pares]

England: BioMed Central Ltd

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5
NAD + cleavage activity by animal and plant TIR domains in cell death pathways
NAD + cleavage activity by animal and plant TIR domains in cell death pathways
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NAD + cleavage activity by animal and plant TIR domains in cell death pathways

Horsefield, Shane ; Burdett, Hayden ; Zhang, Xiaoxiao ; Manik, Mohammad K ; Shi, Yun ; Chen, Jian ; Qi, Tiancong ; Gilley, Jonathan ; Lai, Jhih-Siang ; Rank, Maxwell X ; Casey, Lachlan W ; Gu, Weixi ; Ericsson, Daniel J ; Foley, Gabriel ; Hughes, Robert O ; Bosanac, Todd ; von Itzstein, Mark ; Rathjen, John P ; Nanson, Jeffrey D ; Boden, Mikael ; Dry, Ian B ; Williams, Simon J ; Staskawicz, Brian J ; Coleman, Michael P ; Ve, Thomas ; Dodds, Peter N ; Kobe, Bostjan

Science (American Association for the Advancement of Science), 2019-08, Vol.365 (6455), p.793-799 [Revista revisada por pares]

United States: The American Association for the Advancement of Science

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6
The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins
The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins
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The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins

Casey, Lachlan W. ; Lavrencic, Peter ; Bentham, Adam R. ; Cesari, Stella ; Ericsson, Daniel J. ; Croll, Tristan ; Turk, Dušan ; Anderson, Peter A. ; Mark, Alan E. ; Dodds, Peter N. ; Mobli, Mehdi ; Kobe, Bostjan ; Williams, Simon J.

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (45), p.12856-12861 [Revista revisada por pares]

United States: National Academy of Sciences

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7
TRIF‐dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target
TRIF‐dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target
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TRIF‐dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

Ullah, M. Obayed ; Sweet, Matthew J. ; Mansell, Ashley ; Kellie, Stuart ; Kobe, Bostjan

Journal of leukocyte biology, 2016-07, Vol.100 (1), p.27-45 [Revista revisada por pares]

United States

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8
Molecular basis for specificity of nuclear import and prediction of nuclear localization
Molecular basis for specificity of nuclear import and prediction of nuclear localization
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Molecular basis for specificity of nuclear import and prediction of nuclear localization

Marfori, Mary ; Mynott, Andrew ; Ellis, Jonathan J. ; Mehdi, Ahmed M. ; Saunders, Neil F.W. ; Curmi, Paul M. ; Forwood, Jade K. ; Bodén, Mikael ; Kobe, Bostjan

Biochimica et biophysica acta, 2011-09, Vol.1813 (9), p.1562-1577 [Revista revisada por pares]

Netherlands: Elsevier B.V

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9
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling
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Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling

Manik, Mohammad K ; Shi, Yun ; Li, Sulin ; Zaydman, Mark A ; Damaraju, Neha ; Eastman, Samuel ; Smith, Thomas G ; Gu, Weixi ; Masic, Veronika ; Mosaiab, Tamim ; Weagley, James S ; Hancock, Steven J ; Vasquez, Eduardo ; Hartley-Tassell, Lauren ; Kargios, Nestoras ; Maruta, Natsumi ; Lim, Bryan Y J ; Burdett, Hayden ; Landsberg, Michael J ; Schembri, Mark A ; Prokes, Ivan ; Song, Lijiang ; Grant, Murray ; DiAntonio, Aaron ; Nanson, Jeffrey D ; Guo, Ming ; Milbrandt, Jeffrey ; Ve, Thomas ; Kobe, Bostjan

Science (American Association for the Advancement of Science), 2022-09, Vol.377 (6614), p.eadc8969 [Revista revisada por pares]

United States: The American Association for the Advancement of Science

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10
Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
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Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

Ve, Thomas ; Vajjhala, Parimala R ; Hedger, Andrew ; Croll, Tristan ; DiMaio, Frank ; Horsefield, Shane ; Yu, Xiong ; Lavrencic, Peter ; Hassan, Zahid ; Morgan, Garry P ; Mansell, Ashley ; Mobli, Mehdi ; O'Carroll, Ailis ; Chauvin, Brieuc ; Gambin, Yann ; Sierecki, Emma ; Landsberg, Michael J ; Stacey, Katryn J ; Egelman, Edward H ; Kobe, Bostjan

Nature structural & molecular biology, 2017-09, Vol.24 (9), p.743-751 [Revista revisada por pares]

United States: Nature Publishing Group

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