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Refinado por: assunto: Animals remover Nome da Publicação: Journal Of Medicinal Chemistry remover
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1
Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer
Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer
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Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer

Han, Xin ; Wang, Chao ; Qin, Chong ; Xiang, Weiguo ; Fernandez-Salas, Ester ; Yang, Chao-Yie ; Wang, Mi ; Zhao, Lijie ; Xu, Tianfeng ; Chinnaswamy, Krishnapriya ; Delproposto, James ; Stuckey, Jeanne ; Wang, Shaomeng

Journal of medicinal chemistry, 2019-01, Vol.62 (2), p.941-964 [Periódico revisado por pares]

United States: American Chemical Society

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2
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression
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Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

Qin, Chong ; Hu, Yang ; Zhou, Bing ; Fernandez-Salas, Ester ; Yang, Chao-Yie ; Liu, Liu ; McEachern, Donna ; Przybranowski, Sally ; Wang, Mi ; Stuckey, Jeanne ; Meagher, Jennifer ; Bai, Longchuan ; Chen, Zhuo ; Lin, Mei ; Yang, Jiuling ; Ziazadeh, Danya N ; Xu, Fuming ; Hu, Jiantao ; Xiang, Weiguo ; Huang, Liyue ; Li, Siwei ; Wen, Bo ; Sun, Duxin ; Wang, Shaomeng

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6685-6704 [Periódico revisado por pares]

United States: American Chemical Society

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3
Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer
Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer
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Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer

Han, Xin ; Zhao, Lijie ; Xiang, Weiguo ; Qin, Chong ; Miao, Bukeyan ; McEachern, Donna ; Wang, Yu ; Metwally, Hoda ; Wang, Lu ; Matvekas, Aleksas ; Wen, Bo ; Sun, Duxin ; Wang, Shaomeng

Journal of medicinal chemistry, 2021-09, Vol.64 (17), p.12831-12854 [Periódico revisado por pares]

United States: American Chemical Society

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4
Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase
Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase
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Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase

Gentles, Robert G. ; Ding, Min ; Bender, John A. ; Bergstrom, Carl P. ; Grant-Young, Katharine ; Hewawasam, Piyasena ; Hudyma, Thomas ; Martin, Scott ; Nickel, Andrew ; Regueiro-Ren, Alicia ; Tu, Yong ; Yang, Zhong ; Yeung, Kap-Sun ; Zheng, Xiaofan ; Chao, Sam ; Sun, Jung-Hui ; Beno, Brett R. ; Camac, Daniel M. ; Chang, Chong-Hwan ; Gao, Mian ; Morin, Paul E. ; Sheriff, Steven ; Tredup, Jeff ; Wan, John ; Witmer, Mark R. ; Xie, Dianlin ; Hanumegowda, Umesh ; Knipe, Jay ; Mosure, Kathy ; Santone, Kenneth S. ; Parker, Dawn D. ; Zhuo, Xiaoliang ; Lemm, Julie ; Liu, Mengping ; Pelosi, Lenore ; Rigat, Karen ; Voss, Stacey ; Wang, Yi ; Wang, Ying-Kai ; Colonno, Richard J. ; Gao, Min ; Roberts, Susan B. ; Gao, Qi ; Ng, Alicia ; Meanwell, Nicholas A ; Kadow, John F.

J. Med. Chem, 2014-03, Vol.57 (5), p.1855-1879 [Periódico revisado por pares]

United States: American Chemical Society

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5
Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer
Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer
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Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer

Xiang, Weiguo ; Zhao, Lijie ; Han, Xin ; Qin, Chong ; Miao, Bukeyan ; McEachern, Donna ; Wang, Yu ; Metwally, Hoda ; Kirchhoff, Paul D ; Wang, Lu ; Matvekas, Aleksas ; He, Miao ; Wen, Bo ; Sun, Duxin ; Wang, Shaomeng

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13487-13509 [Periódico revisado por pares]

United States: American Chemical Society

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6
Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class
Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class
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Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

Turner, Steve R ; Strohbach, Joseph W ; Tommasi, Ruben A ; Aristoff, Paul A ; Johnson, Paul D ; Skulnick, Harvey I ; Dolak, Lester A ; Seest, Eric P ; Tomich, Paul K ; Bohanon, Michael J ; Horng, Miao-Miao ; Lynn, Janet C ; Chong, Kong-Teck ; Hinshaw, Roger R ; Watenpaugh, Keith D ; Janakiraman, Musiri N ; Thaisrivongs, Suvit

Journal of medicinal chemistry, 1998-08, Vol.41 (18), p.3467-3476 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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7
Discovery of Novel 2,3-Dihydro-1 H -indene-5-sulfonamide NLRP3 Inflammasome Inhibitors Targeting Colon as a Potential Therapy for Colitis
Discovery of Novel 2,3-Dihydro-1 H -indene-5-sulfonamide NLRP3 Inflammasome Inhibitors Targeting Colon as a Potential Therapy for Colitis
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Discovery of Novel 2,3-Dihydro-1 H -indene-5-sulfonamide NLRP3 Inflammasome Inhibitors Targeting Colon as a Potential Therapy for Colitis

Sun, Simin ; Li, Zhuoyue ; Huang, Chao ; Liu, Jinyu ; Yu, Qixin ; Jiang, Xiaolin ; Yue, Kairui ; Zhao, Jianchun ; Xu, Tongqiang ; Liu, Yankai ; Li, Xiaoyang ; Qin, Chong ; Jiang, Yuqi

Journal of medicinal chemistry, 2023-12, Vol.66 (23), p.16141-16167 [Periódico revisado por pares]

United States

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8
Discovery of 3,4-Dihydrobenzo[f][1,4]oxazepin-5(2H)‑one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects
Discovery of 3,4-Dihydrobenzo[f][1,4]oxazepin-5(2H)‑one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects
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Discovery of 3,4-Dihydrobenzo[f][1,4]oxazepin-5(2H)‑one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects

Li, Yueshan ; Zhang, Liting ; Yang, Ruicheng ; Qiao, Zeen ; Wu, Ming ; Huang, Chong ; Tian, Chenyu ; Luo, Xinling ; Yang, Wei ; Zhang, Yun ; Li, Linli ; Yang, Shengyong

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.1786-1807 [Periódico revisado por pares]

United States: American Chemical Society

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9
Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat
Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat
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Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat

Yao, Lianbin ; Mustafa, Nurulhuda ; Tan, Eng Chong ; Poulsen, Anders ; Singh, Prachi ; Duong-Thi, Minh-Dao ; Lee, Jeannie X. T ; Ramanujulu, Pondy Murugappan ; Chng, Wee Joo ; Yen, Jeffrey J. Y ; Ohlson, Sten ; Dymock, Brian W

Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8336-8357 [Periódico revisado por pares]

United States: American Chemical Society

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10
Design and Synthesis of Oxymatrine Analogues Overcoming Drug Resistance in Hepatitis B Virus through Targeting Host Heat Stress Cognate 70
Design and Synthesis of Oxymatrine Analogues Overcoming Drug Resistance in Hepatitis B Virus through Targeting Host Heat Stress Cognate 70
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Design and Synthesis of Oxymatrine Analogues Overcoming Drug Resistance in Hepatitis B Virus through Targeting Host Heat Stress Cognate 70

Gao, Li-Mei ; Han, Yan-Xing ; Wang, Yu-Ping ; Li, Yu-Huan ; Shan, Yong-Qiang ; Li, Xin ; Peng, Zong-Gen ; Bi, Chong-Wen ; Zhang, Tian ; Du, Na-Na ; Jiang, Jian-Dong ; Song, Dan-Qing

Journal of medicinal chemistry, 2011-02, Vol.54 (3), p.869-876 [Periódico revisado por pares]

United States: American Chemical Society

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