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1
Structures of l‐proline trans‐hydroxylase reveal the catalytic specificity and provide deeper insight into AKG‐dependent hydroxylation
Structures of l‐proline trans‐hydroxylase reveal the catalytic specificity and provide deeper insight into AKG‐dependent hydroxylation
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Structures of l‐proline trans‐hydroxylase reveal the catalytic specificity and provide deeper insight into AKG‐dependent hydroxylation

Hu, Xiaoyan ; Huang, Xue ; Liu, Jiao ; Zheng, Ping ; Gong, Weimin ; Yang, Lin

Acta crystallographica. Section D, Biological crystallography., 2023-04, Vol.79 (4), p.318-325 [Revista revisada por pares]

5 Abbey Square, Chester, Cheshire CH1 2HU, England: International Union of Crystallography

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2
An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
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An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

Owen, Dafydd R ; Allerton, Charlotte M N ; Anderson, Annaliesa S ; Aschenbrenner, Lisa ; Avery, Melissa ; Berritt, Simon ; Boras, Britton ; Cardin, Rhonda D ; Carlo, Anthony ; Coffman, Karen J ; Dantonio, Alyssa ; Di, Li ; Eng, Heather ; Ferre, RoseAnn ; Gajiwala, Ketan S ; Gibson, Scott A ; Greasley, Samantha E ; Hurst, Brett L ; Kadar, Eugene P ; Kalgutkar, Amit S ; Lee, Jack C ; Lee, Jisun ; Liu, Wei ; Mason, Stephen W ; Noell, Stephen ; Novak, Jonathan J ; Obach, R Scott ; Ogilvie, Kevin ; Patel, Nandini C ; Pettersson, Martin ; Rai, Devendra K ; Reese, Matthew R ; Sammons, Matthew F ; Sathish, Jean G ; Singh, Ravi Shankar P ; Steppan, Claire M ; Stewart, Al E ; Tuttle, Jamison B ; Updyke, Lawrence ; Verhoest, Patrick R ; Wei, Liuqing ; Yang, Qingyi ; Zhu, Yuao

Science (American Association for the Advancement of Science), 2021-12, Vol.374 (6575), p.1586-1593 [Revista revisada por pares]

United States

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3
Recharacterization of the mammalian cytosolic type 2 (R)-β-hydroxybutyrate dehydrogenase as 4-oxo-l-proline reductase (EC 1.1.1.104)
Recharacterization of the mammalian cytosolic type 2 (R)-β-hydroxybutyrate dehydrogenase as 4-oxo-l-proline reductase (EC 1.1.1.104)
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Recharacterization of the mammalian cytosolic type 2 (R)-β-hydroxybutyrate dehydrogenase as 4-oxo-l-proline reductase (EC 1.1.1.104)

Kwiatkowski, Sebastian ; Bozko, Maria ; Zarod, Michal ; Witecka, Apolonia ; Kocdemir, Kubra ; Jagielski, Adam K. ; Drozak, Jakub

The Journal of biological chemistry, 2022-03, Vol.298 (3), p.101708-101708, Article 101708 [Revista revisada por pares]

United States: Elsevier Inc

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4
A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-L-proline
A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-L-proline
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A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-L-proline

Levin, B. J. ; Huang, Y. Y. ; Peck, S. C. ; Wei, Y. ; Martínez-del Campo, A. ; Marks, J. A. ; Franzosa, E. A. ; Huttenhower, C. ; Balskus, E. P.

Science (American Association for the Advancement of Science), 2017-02, Vol.355 (6325), p.595-595 [Revista revisada por pares]

United States: American Association for the Advancement of Science

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5
HIF-1α metabolically controls collagen synthesis and modification in chondrocytes
HIF-1α metabolically controls collagen synthesis and modification in chondrocytes
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HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

Stegen, Steve ; Laperre, Kjell ; Eelen, Guy ; Rinaldi, Gianmarco ; Fraisl, Peter ; Torrekens, Sophie ; Van Looveren, Riet ; Loopmans, Shauni ; Bultynck, Geert ; Vinckier, Stefan ; Meersman, Filip ; Maxwell, Patrick H ; Rai, Jyoti ; Weis, MaryAnn ; Eyre, David R ; Ghesquière, Bart ; Fendt, Sarah-Maria ; Carmeliet, Peter ; Carmeliet, Geert

Nature (London), 2019-01, Vol.565 (7740), p.511-515 [Revista revisada por pares]

England: Nature Publishing Group

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6
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19
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Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19

Hammond, Jennifer ; Leister-Tebbe, Heidi ; Gardner, Annie ; Abreu, Paula ; Bao, Weihang ; Wisemandle, Wayne ; Baniecki, MaryLynn ; Hendrick, Victoria M ; Damle, Bharat ; Simón-Campos, Abraham ; Pypstra, Rienk ; Rusnak, James M

The New England journal of medicine, 2022-04, Vol.386 (15), p.1397-1408 [Revista revisada por pares]

United States: Massachusetts Medical Society

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7
Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis
Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis
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Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis

Choi, Un Yung ; Lee, Jae Jin ; Park, Angela ; Zhu, Wei ; Lee, Hye-Ra ; Choi, Youn Jung ; Yoo, Ji-Seung ; Yu, Claire ; Feng, Pinghui ; Gao, Shou-Jiang ; Chen, Shaochen ; Eoh, Hyungjin ; Jung, Jae U.

Proceedings of the National Academy of Sciences - PNAS, 2020-04, Vol.117 (14), p.8083-8093 [Revista revisada por pares]

United States: National Academy of Sciences

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8
Boceprevir for Untreated Chronic HCV Genotype 1 Infection
Boceprevir for Untreated Chronic HCV Genotype 1 Infection
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Boceprevir for Untreated Chronic HCV Genotype 1 Infection

Poordad, Fred ; McCone, Jonathan ; Bacon, Bruce R ; Bruno, Savino ; Manns, Michael P ; Sulkowski, Mark S ; Jacobson, Ira M ; Reddy, K. Rajender ; Goodman, Zachary D ; Boparai, Navdeep ; DiNubile, Mark J ; Sniukiene, Vilma ; Brass, Clifford A ; Albrecht, Janice K ; Bronowicki, Jean-Pierre

The New England journal of medicine, 2011-03, Vol.364 (13), p.1195-1206 [Revista revisada por pares]

Waltham, MA: Massachusetts Medical Society

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9
Deletion of prolyl hydroxylase domain-containing enzyme 3 (phd3) in zebrafish facilitates hypoxia tolerance
Deletion of prolyl hydroxylase domain-containing enzyme 3 (phd3) in zebrafish facilitates hypoxia tolerance
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Deletion of prolyl hydroxylase domain-containing enzyme 3 (phd3) in zebrafish facilitates hypoxia tolerance

Liao, Qian ; Deng, Hongyan ; Wang, Zixuan ; Yu, Guangqing ; Zhu, Chunchun ; Jia, Shuke ; Liu, Wen ; Bai, Yao ; Sun, Xueyi ; Chen, Xiaoyun ; Xiao, Wuhan ; Liu, Xing

The Journal of biological chemistry, 2023-12, Vol.299 (12), p.105420-105420, Article 105420 [Revista revisada por pares]

United States: Elsevier Inc

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10
Abstract 2435 Investigating the Effects of T239V Mutation in Pyrroline-5-Carboxylate Reductase
Abstract 2435 Investigating the Effects of T239V Mutation in Pyrroline-5-Carboxylate Reductase
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Abstract 2435 Investigating the Effects of T239V Mutation in Pyrroline-5-Carboxylate Reductase

Ali, Suad ; Bruender, Nathan

The Journal of biological chemistry, 2024-03, Vol.300 (3) [Revista revisada por pares]

Elsevier Inc

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