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Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2
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Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2

Drayman, Nir ; DeMarco, Jennifer K ; Jones, Krysten A ; Azizi, Saara-Anne ; Froggatt, Heather M ; Tan, Kemin ; Maltseva, Natalia Ivanovna ; Chen, Siquan ; Nicolaescu, Vlad ; Dvorkin, Steve ; Furlong, Kevin ; Kathayat, Rahul S ; Firpo, Mason R ; Mastrodomenico, Vincent ; Bruce, Emily A ; Schmidt, Madaline M ; Jedrzejczak, Robert ; Muñoz-Alía, Miguel Á ; Schuster, Brooke ; Nair, Vishnu ; Han, Kyu-Yeon ; O'Brien, Amornrat ; Tomatsidou, Anastasia ; Meyer, Bjoern ; Vignuzzi, Marco ; Missiakas, Dominique ; Botten, Jason W ; Brooke, Christopher B ; Lee, Hyun ; Baker, Susan C ; Mounce, Bryan C ; Heaton, Nicholas S ; Severson, William E ; Palmer, Kenneth E ; Dickinson, Bryan C ; Joachimiak, Andrzej ; Randall, Glenn ; Tay, Savaş

Science (American Association for the Advancement of Science), 2021-08, Vol.373 (6557), p.931-936 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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2
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

Zheng, Qinheng ; Woehl, Jordan L. ; Kitamura, Seiya ; Santos-Martins, Diogo ; Smedley, Christopher J. ; Li, Gencheng ; Forli, Stefano ; Moses, John E. ; Wolan, Dennis W. ; Sharpless, K. Barry

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (38), p.18808-18814 [Periódico revisado por pares]

United States: National Academy of Sciences

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3
Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure‐Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects
Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure‐Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects
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Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure‐Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects

Palmér, Robert ; Mäenpää, Jukka ; Jauhiainen, Alexandra ; Larsson, Bengt ; Mo, John ; Russell, Muir ; Root, James ; Prothon, Susanne ; Chialda, Ligia ; Forte, Pablo ; Egelrud, Torbjörn ; Stenvall, Kristina ; Gardiner, Philip

Clinical pharmacology and therapeutics, 2018-12, Vol.104 (6), p.1155-1164 [Periódico revisado por pares]

United States: John Wiley and Sons Inc

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4
Biased signalling and proteinase‐activated receptors (PARs): targeting inflammatory disease
Biased signalling and proteinase‐activated receptors (PARs): targeting inflammatory disease
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Biased signalling and proteinase‐activated receptors (PARs): targeting inflammatory disease

Hollenberg, M D ; Mihara, K ; Polley, D ; Suen, J Y ; Han, A ; Fairlie, D P ; Ramachandran, R

British journal of pharmacology, 2014-03, Vol.171 (5), p.1180-1194 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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5
A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic

Shapira, Tirosh ; Monreal, I Abrrey ; Dion, Sébastien P ; Buchholz, David W ; Imbiakha, Brian ; Olmstead, Andrea D ; Jager, Mason ; Désilets, Antoine ; Gao, Guang ; Martins, Mathias ; Vandal, Thierry ; Thompson, Connor A H ; Chin, Aaleigha ; Rees, William D ; Steiner, Theodore ; Nabi, Ivan Robert ; Marsault, Eric ; Sahler, Julie ; Diel, Diego G ; Van de Walle, Gerlinde R ; August, Avery ; Whittaker, Gary R ; Boudreault, Pierre-Luc ; Leduc, Richard ; Aguilar, Hector C ; Jean, François

Nature (London), 2022-05, Vol.605 (7909), p.340-348 [Periódico revisado por pares]

England: Nature Publishing Group

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6
Boceprevir for Untreated Chronic HCV Genotype 1 Infection
Boceprevir for Untreated Chronic HCV Genotype 1 Infection
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Boceprevir for Untreated Chronic HCV Genotype 1 Infection

Poordad, Fred ; McCone, Jonathan ; Bacon, Bruce R ; Bruno, Savino ; Manns, Michael P ; Sulkowski, Mark S ; Jacobson, Ira M ; Reddy, K. Rajender ; Goodman, Zachary D ; Boparai, Navdeep ; DiNubile, Mark J ; Sniukiene, Vilma ; Brass, Clifford A ; Albrecht, Janice K ; Bronowicki, Jean-Pierre

The New England journal of medicine, 2011-03, Vol.364 (13), p.1195-1206 [Periódico revisado por pares]

Waltham, MA: Massachusetts Medical Society

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7
Proteasome inhibitors in multiple myeloma: 10 years later
Proteasome inhibitors in multiple myeloma: 10 years later
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Proteasome inhibitors in multiple myeloma: 10 years later

Moreau, Philippe ; Richardson, Paul G. ; Cavo, Michele ; Orlowski, Robert Z. ; San Miguel, Jesús F. ; Palumbo, Antonio ; Harousseau, Jean-Luc

Blood, 2012-08, Vol.120 (5), p.947-959 [Periódico revisado por pares]

Washington, DC: Elsevier Inc

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8
NSP4, an elastase-related protease in human neutrophils with arginine specificity
NSP4, an elastase-related protease in human neutrophils with arginine specificity
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NSP4, an elastase-related protease in human neutrophils with arginine specificity

Perera, Natascha C ; Schilling, Oliver ; Kittel, Heike ; Back, Walter ; Kremmer, Elisabeth ; Jenne, Dieter E

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (16), p.6229-6234 [Periódico revisado por pares]

United States: National Academy of Sciences

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9
Identification of highly selective covalent inhibitors by phage display
Identification of highly selective covalent inhibitors by phage display
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Identification of highly selective covalent inhibitors by phage display

Chen, Shiyu ; Lovell, Scott ; Lee, Sumin ; Fellner, Matthias ; Mace, Peter D ; Bogyo, Matthew

Nature biotechnology, 2021-04, Vol.39 (4), p.490-498 [Periódico revisado por pares]

United States: Nature Publishing Group

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10
Canonical or noncanonical? Structural plasticity of serine protease‐binding loops in Kunitz‐STI protease inhibitors
Canonical or noncanonical? Structural plasticity of serine protease‐binding loops in Kunitz‐STI protease inhibitors
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Canonical or noncanonical? Structural plasticity of serine protease‐binding loops in Kunitz‐STI protease inhibitors

Guerra, Yasel ; Armijos‐Jaramillo, Vinicio ; Pons, Tirso ; Tejera, Eduardo ; Berry, Colin

Protein science, 2023-02, Vol.32 (2), p.e4570-n/a [Periódico revisado por pares]

Hoboken, USA: John Wiley & Sons, Inc

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