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Engineering the serpin α1‐antitrypsin: A diversity of goals and techniques
Engineering the serpin α1‐antitrypsin: A diversity of goals and techniques
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Engineering the serpin α1‐antitrypsin: A diversity of goals and techniques

Scott, Benjamin M. ; Sheffield, William P.

Protein science, 2020-04, Vol.29 (4), p.856-871 [Periódico revisado por pares]

Hoboken, USA: John Wiley & Sons, Inc

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2
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
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Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

Riva, Laura ; Yuan, Shuofeng ; Yin, Xin ; Martin-Sancho, Laura ; Matsunaga, Naoko ; Pache, Lars ; Burgstaller-Muehlbacher, Sebastian ; De Jesus, Paul D ; Teriete, Peter ; Hull, Mitchell V ; Chang, Max W ; Chan, Jasper Fuk-Woo ; Cao, Jianli ; Poon, Vincent Kwok-Man ; Herbert, Kristina M ; Cheng, Kuoyuan ; Nguyen, Tu-Trinh H ; Rubanov, Andrey ; Pu, Yuan ; Nguyen, Courtney ; Choi, Angela ; Rathnasinghe, Raveen ; Schotsaert, Michael ; Miorin, Lisa ; Dejosez, Marion ; Zwaka, Thomas P ; Sit, Ko-Yung ; Martinez-Sobrido, Luis ; Liu, Wen-Chun ; White, Kris M ; Chapman, Mackenzie E ; Lendy, Emma K ; Glynne, Richard J ; Albrecht, Randy ; Ruppin, Eytan ; Mesecar, Andrew D ; Johnson, Jeffrey R ; Benner, Christopher ; Sun, Ren ; Schultz, Peter G ; Su, Andrew I ; García-Sastre, Adolfo ; Chatterjee, Arnab K ; Yuen, Kwok-Yung ; Chanda, Sumit K

Nature (London), 2020-10, Vol.586 (7827), p.113-119 [Periódico revisado por pares]

England: Nature Publishing Group

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3
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2
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Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2

Drayman, Nir ; DeMarco, Jennifer K ; Jones, Krysten A ; Azizi, Saara-Anne ; Froggatt, Heather M ; Tan, Kemin ; Maltseva, Natalia Ivanovna ; Chen, Siquan ; Nicolaescu, Vlad ; Dvorkin, Steve ; Furlong, Kevin ; Kathayat, Rahul S ; Firpo, Mason R ; Mastrodomenico, Vincent ; Bruce, Emily A ; Schmidt, Madaline M ; Jedrzejczak, Robert ; Muñoz-Alía, Miguel Á ; Schuster, Brooke ; Nair, Vishnu ; Han, Kyu-Yeon ; O'Brien, Amornrat ; Tomatsidou, Anastasia ; Meyer, Bjoern ; Vignuzzi, Marco ; Missiakas, Dominique ; Botten, Jason W ; Brooke, Christopher B ; Lee, Hyun ; Baker, Susan C ; Mounce, Bryan C ; Heaton, Nicholas S ; Severson, William E ; Palmer, Kenneth E ; Dickinson, Bryan C ; Joachimiak, Andrzej ; Randall, Glenn ; Tay, Savaş

Science (American Association for the Advancement of Science), 2021-08, Vol.373 (6557), p.931-936 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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4
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

Zheng, Qinheng ; Woehl, Jordan L. ; Kitamura, Seiya ; Santos-Martins, Diogo ; Smedley, Christopher J. ; Li, Gencheng ; Forli, Stefano ; Moses, John E. ; Wolan, Dennis W. ; Sharpless, K. Barry

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (38), p.18808-18814 [Periódico revisado por pares]

United States: National Academy of Sciences

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5
Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure‐Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects
Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure‐Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects
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Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure‐Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects

Palmér, Robert ; Mäenpää, Jukka ; Jauhiainen, Alexandra ; Larsson, Bengt ; Mo, John ; Russell, Muir ; Root, James ; Prothon, Susanne ; Chialda, Ligia ; Forte, Pablo ; Egelrud, Torbjörn ; Stenvall, Kristina ; Gardiner, Philip

Clinical pharmacology and therapeutics, 2018-12, Vol.104 (6), p.1155-1164 [Periódico revisado por pares]

United States: John Wiley and Sons Inc

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6
A proteomic atlas of senescence-associated secretomes for aging biomarker development
A proteomic atlas of senescence-associated secretomes for aging biomarker development
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A proteomic atlas of senescence-associated secretomes for aging biomarker development

Basisty, Nathan ; Kale, Abhijit ; Jeon, Ok Hee ; Kuehnemann, Chisaka ; Payne, Therese ; Rao, Chirag ; Holtz, Anja ; Shah, Samah ; Sharma, Vagisha ; Ferrucci, Luigi ; Campisi, Judith ; Schilling, Birgit Serrano, Manuel

PLoS biology, 2020-01, Vol.18 (1), p.e3000599-e3000599 [Periódico revisado por pares]

United States: Public Library of Science

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7
Biased signalling and proteinase‐activated receptors (PARs): targeting inflammatory disease
Biased signalling and proteinase‐activated receptors (PARs): targeting inflammatory disease
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Biased signalling and proteinase‐activated receptors (PARs): targeting inflammatory disease

Hollenberg, M D ; Mihara, K ; Polley, D ; Suen, J Y ; Han, A ; Fairlie, D P ; Ramachandran, R

British journal of pharmacology, 2014-03, Vol.171 (5), p.1180-1194 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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8
A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic

Shapira, Tirosh ; Monreal, I Abrrey ; Dion, Sébastien P ; Buchholz, David W ; Imbiakha, Brian ; Olmstead, Andrea D ; Jager, Mason ; Désilets, Antoine ; Gao, Guang ; Martins, Mathias ; Vandal, Thierry ; Thompson, Connor A H ; Chin, Aaleigha ; Rees, William D ; Steiner, Theodore ; Nabi, Ivan Robert ; Marsault, Eric ; Sahler, Julie ; Diel, Diego G ; Van de Walle, Gerlinde R ; August, Avery ; Whittaker, Gary R ; Boudreault, Pierre-Luc ; Leduc, Richard ; Aguilar, Hector C ; Jean, François

Nature (London), 2022-05, Vol.605 (7909), p.340-348 [Periódico revisado por pares]

England: Nature Publishing Group

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9
Boceprevir for Untreated Chronic HCV Genotype 1 Infection
Boceprevir for Untreated Chronic HCV Genotype 1 Infection
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Boceprevir for Untreated Chronic HCV Genotype 1 Infection

Poordad, Fred ; McCone, Jonathan ; Bacon, Bruce R ; Bruno, Savino ; Manns, Michael P ; Sulkowski, Mark S ; Jacobson, Ira M ; Reddy, K. Rajender ; Goodman, Zachary D ; Boparai, Navdeep ; DiNubile, Mark J ; Sniukiene, Vilma ; Brass, Clifford A ; Albrecht, Janice K ; Bronowicki, Jean-Pierre

The New England journal of medicine, 2011-03, Vol.364 (13), p.1195-1206 [Periódico revisado por pares]

Waltham, MA: Massachusetts Medical Society

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10
Proteasome inhibitors in multiple myeloma: 10 years later
Proteasome inhibitors in multiple myeloma: 10 years later
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Proteasome inhibitors in multiple myeloma: 10 years later

Moreau, Philippe ; Richardson, Paul G. ; Cavo, Michele ; Orlowski, Robert Z. ; San Miguel, Jesús F. ; Palumbo, Antonio ; Harousseau, Jean-Luc

Blood, 2012-08, Vol.120 (5), p.947-959 [Periódico revisado por pares]

Washington, DC: Elsevier Inc

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