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Material Type: Artigo
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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesisWILHELM, Scott M ; CARTER, Christopher ; CAO, Yichen ; SHUJATH, Jaleel ; GAWLAK, Susan ; EVELEIGH, Deepa ; ROWLEY, Bruce ; LI LIU ; ADNANE, Lila ; LYNCH, Mark ; AUCLAIR, Daniel ; TAYLOR, Ian ; TANG, Liya ; GEDRICH, Rich ; VOZNESENSKY, Andrei ; RIEDL, Bernd ; POST, Leonard E ; BOLLAG, Gideon ; TRAIL, Pamela A ; WILKIE, Dean ; MCNABOLA, Angela ; HONG RONG ; CHEN, Charles ; XIAOMEI ZHANG ; VINCENT, Patrick ; MCHUGH, MarkCancer research (Chicago, Ill.), 2004-10, Vol.64 (19), p.7099-7109 [Periódico revisado por pares]Philadelphia, PA: American Association for Cancer ResearchTexto completo disponível |
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Material Type: Artigo
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Paclitaxel enhances in vitro radiosensitivity of squamous carcinoma cell lines of the head and neckLEONARD, C. E ; CHAN, D. C ; CHOU, T.-C ; KUMAR, R ; BUNN, P. ACancer research (Chicago, Ill.), 1996-11, Vol.56 (22), p.5198-5204 [Periódico revisado por pares]Philadelphia, PA: American Association for Cancer ResearchTexto completo disponível |
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Material Type: Artigo
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Abstract 4888: Antibody blockade of semaphorin 4D breaks down stromal barriers to enhance tumoricidal immune infiltration, supporting rational immunotherapy combinationsEvans, Elizabeth E. ; Bussler, Holm ; Torno, Sebold ; Mallow, Crystal ; Reilly, Christine ; Scrivens, Maria ; Klimatcheva, Ekaterina ; Winter, Laurie A. ; Kirk, Renee ; Howell, Alan ; Balch, Leslie ; Leonard, John E. ; Paris, Mark ; Fisher, Terrence L. ; Hu-Lieskovan, Siwen ; Ribas, Antoni ; Smith, Ernest S. ; Zauderer, MauriceCancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4888-4888 [Periódico revisado por pares]Texto completo disponível |
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Material Type: Artigo
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Abstract PD1-01: Open-label, randomized, phase 2 study of sapanisertib (TAK-228/MLN0128) in combination with fulvestrant in postmenopausal women with estrogen receptor-positive (ER+)/human epidermal growth factor receptor-2-negative (HER2-) advanced or metastatic breast cancer (MBC) that previously progressed during or after aromatase inhibitor therapy (NCT02756364)García-Saenz, José Á ; Jáñez, Noelia Martínez ; Martin, Miguel ; Martínez, Ainhara Lahuerta ; González-Santiago, Santiago ; Ferrer, Nieves ; Vázquez, Manuel Ramos ; Romero, José Luis Alonso ; Antón, Antonio ; Carrasco, Eva ; Chen, Jingjing ; Neuwirth, Rachel ; Leonard, E Jane ; Slamon, DennisCancer research (Chicago, Ill.), 2021-02, Vol.81 (4_Supplement), p.PD1-01-PD1-01 [Periódico revisado por pares]Texto completo disponível |
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Material Type: Artigo
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Abstract CT249: First-in-human study of TAK-500, a novel STING agonist immune stimulating antibody conjugate (ISAC), alone and in combination with pembrolizumab in patients with select advanced solid tumorsDiamond, Jennifer R. ; Henry, Jason T. ; Falchook, Gerald S. ; Olszanski, Anthony J. ; Singh, Harshabad ; Leonard, E. Jane ; Gregory, Richard C. ; Appleman, Vicky A. ; Gibbs, John P. ; Harbison, Carole E. ; Li, Cong ; Sapiro, Jessica M. ; Yoneyama, Tomoki ; Parent, Alexander ; Chung, VincentCancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.CT249-CT249 [Periódico revisado por pares]Texto completo disponível |
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Material Type: Artigo
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Abstract LB-156: New-onset cancer cases in FDA’s Sentinel System: A large distributed system of US electronic healthcare dataHaug, Nicole R. ; Wagner, Anita K. ; McGlynn, Katherine A. ; Leonard, Charles E. ; Nguyen, Michael D. ; Major, Jacqueline M.Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.LB-156-LB-156 [Periódico revisado por pares]Texto completo disponível |
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Material Type: Artigo
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Abstract CT086: Interim results from CLASSICAL-Lung, a Phase Ib/II study of VX15/2503 (pepinemab) in combination with avelumab in advanced NSCLCShafique, Michael ; Fisher, Terrence L. ; Evans, Elizabeth E. ; Leonard, John E. ; Pastore, Desa Rae ; Mallow, Crystal ; Smith, Ernest ; Zauderer, Maurice ; Schröeder, Andreas ; Chin, Kevin ; Beck, Thaddeus ; Baumgart, Megan ; Sanborn, Rachel E. ; Goldman, Jonathan W.Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.CT086-CT086 [Periódico revisado por pares]Texto completo disponível |
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Material Type: Artigo
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Abstract CT016: Integrated biomarker trials of VX15/2503 (pepinemab) in combination with checkpoint inhibitors in window of opportunity studies in solid tumorsLesinski, Gregory B. ; Fisher, Terrence L. ; Evans, Elizabeth E. ; Leonard, John E. ; Pastore, Desa Rae ; Mallow, Crystal ; Smith, Ernest ; Zauderer, Maurice ; Steuer, Conor ; Saba, Nabil F. ; Lowe, Michael ; Kudchadkar, Ragini R. ; Olson, Brian ; Wu, ChristinaCancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.CT016-CT016 [Periódico revisado por pares]Texto completo disponível |
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Material Type: Artigo
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Abstract CT191: Interim results from CLASSICAL-Lung, phase 1b/2 study of pepinemab (VX15/2503) in combination with avelumab in advanced NSCLCGoldman, Jonathan W. ; Fisher, Terrence L. ; Evans, Elizabeth ; Leonard, John E. ; Pastore, Desa Rae ; Mallow, Crystal ; Smith, Ernest ; Schröeder, Andreas ; Chin, Kevin ; Shafique, Michael ; Beck, Thaddeus ; Baumgart, Megan A. ; Govindan, Ramaswamy ; Gabrail, Nashat ; Sanborn, Rachel E. ; Spira, Alexander I. ; Seetharamu, Nagashree ; Lou, Yanyan ; Mansfield, Aaron S. ; Zauderer, MauriceCancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.CT191-CT191 [Periódico revisado por pares]Texto completo disponível |
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Material Type: Artigo
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Abstract PD1-09: Phase 2 safety and efficacy results of TAK-228 in combination with exemestane or fulvestrant in postmenopausal women with ER-positive/HER2-negative metastatic breast cancer previously treated with everolimusDiamond, JR ; Potter, D ; Salkeni, M ; Silverman, P ; Haddad, T ; Forget, F ; Awada, A ; Canon, J-L ; Danso, M ; Lortholary, A ; Bourgeois, H ; Tan-Chiu, E ; Patel, C ; Neuwirth, R ; Leonard, EJ ; Lim, BCancer research (Chicago, Ill.), 2019-02, Vol.79 (4_Supplement), p.PD1-09-PD1-09 [Periódico revisado por pares]Texto completo disponível |