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Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
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Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

Riva, Laura ; Yuan, Shuofeng ; Yin, Xin ; Martin-Sancho, Laura ; Matsunaga, Naoko ; Pache, Lars ; Burgstaller-Muehlbacher, Sebastian ; De Jesus, Paul D ; Teriete, Peter ; Hull, Mitchell V ; Chang, Max W ; Chan, Jasper Fuk-Woo ; Cao, Jianli ; Poon, Vincent Kwok-Man ; Herbert, Kristina M ; Cheng, Kuoyuan ; Nguyen, Tu-Trinh H ; Rubanov, Andrey ; Pu, Yuan ; Nguyen, Courtney ; Choi, Angela ; Rathnasinghe, Raveen ; Schotsaert, Michael ; Miorin, Lisa ; Dejosez, Marion ; Zwaka, Thomas P ; Sit, Ko-Yung ; Martinez-Sobrido, Luis ; Liu, Wen-Chun ; White, Kris M ; Chapman, Mackenzie E ; Lendy, Emma K ; Glynne, Richard J ; Albrecht, Randy ; Ruppin, Eytan ; Mesecar, Andrew D ; Johnson, Jeffrey R ; Benner, Christopher ; Sun, Ren ; Schultz, Peter G ; Su, Andrew I ; García-Sastre, Adolfo ; Chatterjee, Arnab K ; Yuen, Kwok-Yung ; Chanda, Sumit K

Nature (London), 2020-10, Vol.586 (7827), p.113-119 [Periódico revisado por pares]

England: Nature Publishing Group

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Camostat mesylate against SARS‐CoV‐2 and COVID‐19—Rationale, dosing and safety
Camostat mesylate against SARS‐CoV‐2 and COVID‐19—Rationale, dosing and safety
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Camostat mesylate against SARS‐CoV‐2 and COVID‐19—Rationale, dosing and safety

Breining, Peter ; Frølund, Anne Lier ; Højen, Jesper Falkesgaard ; Gunst, Jesper Damsgaard ; Staerke, Nina B. ; Saedder, Eva ; Cases‐Thomas, Manuel ; Little, Paul ; Nielsen, Lars Peter ; Søgaard, Ole S. ; Kjolby, Mads

Basic & clinical pharmacology & toxicology, 2021-02, Vol.128 (2), p.204-212 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

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3
Organic Carbamates in Drug Design and Medicinal Chemistry
Organic Carbamates in Drug Design and Medicinal Chemistry
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Organic Carbamates in Drug Design and Medicinal Chemistry

Ghosh, Arun K ; Brindisi, Margherita

Journal of medicinal chemistry, 2015-04, Vol.58 (7), p.2895-2940 [Periódico revisado por pares]

United States: American Chemical Society

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4
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

Zheng, Qinheng ; Woehl, Jordan L. ; Kitamura, Seiya ; Santos-Martins, Diogo ; Smedley, Christopher J. ; Li, Gencheng ; Forli, Stefano ; Moses, John E. ; Wolan, Dennis W. ; Sharpless, K. Barry

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (38), p.18808-18814 [Periódico revisado por pares]

United States: National Academy of Sciences

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5
Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets
Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets
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Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets

Sriram, Krishna ; Insel, Paul A

Physiological reviews, 2021-04, Vol.101 (2), p.545-567 [Periódico revisado por pares]

United States: American Physiological Society

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6
A proteomic atlas of senescence-associated secretomes for aging biomarker development
A proteomic atlas of senescence-associated secretomes for aging biomarker development
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A proteomic atlas of senescence-associated secretomes for aging biomarker development

Basisty, Nathan ; Kale, Abhijit ; Jeon, Ok Hee ; Kuehnemann, Chisaka ; Payne, Therese ; Rao, Chirag ; Holtz, Anja ; Shah, Samah ; Sharma, Vagisha ; Ferrucci, Luigi ; Campisi, Judith ; Schilling, Birgit Serrano, Manuel

PLoS biology, 2020-01, Vol.18 (1), p.e3000599-e3000599 [Periódico revisado por pares]

United States: Public Library of Science

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7
A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors
A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors
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A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors

Yang, Kai S. ; Ma, Xinyu R. ; Ma, Yuying ; Alugubelli, Yugendar R. ; Scott, Danielle A. ; Vatansever, Erol C. ; Drelich, Aleksandra K. ; Sankaran, Banumathi ; Geng, Zhi Z. ; Blankenship, Lauren R. ; Ward, Hannah E. ; Sheng, Yan J. ; Hsu, Jason C. ; Kratch, Kaci C. ; Zhao, Baoyu ; Hayatshahi, Hamed S. ; Liu, Jin ; Li, Pingwei ; Fierke, Carol A. ; Tseng, Chien‐Te K. ; Xu, Shiqing ; Liu, Wenshe Ray

ChemMedChem, 2021-03, Vol.16 (6), p.942-948 [Periódico revisado por pares]

Germany: Wiley Subscription Services, Inc

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8
A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic

Shapira, Tirosh ; Monreal, I Abrrey ; Dion, Sébastien P ; Buchholz, David W ; Imbiakha, Brian ; Olmstead, Andrea D ; Jager, Mason ; Désilets, Antoine ; Gao, Guang ; Martins, Mathias ; Vandal, Thierry ; Thompson, Connor A H ; Chin, Aaleigha ; Rees, William D ; Steiner, Theodore ; Nabi, Ivan Robert ; Marsault, Eric ; Sahler, Julie ; Diel, Diego G ; Van de Walle, Gerlinde R ; August, Avery ; Whittaker, Gary R ; Boudreault, Pierre-Luc ; Leduc, Richard ; Aguilar, Hector C ; Jean, François

Nature (London), 2022-05, Vol.605 (7909), p.340-348 [Periódico revisado por pares]

England: Nature Publishing Group

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9
Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity
Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity
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Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity

Shen, Zhengnan ; Ratia, Kiira ; Cooper, Laura ; Kong, Deyu ; Lee, Hyun ; Kwon, Youngjin ; Li, Yangfeng ; Alqarni, Saad ; Huang, Fei ; Dubrovskyi, Oleksii ; Rong, Lijun ; Thatcher, Gregory R J ; Xiong, Rui

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2940-2955 [Periódico revisado por pares]

United States

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10
Expedited Approach toward the Rational Design of Noncovalent SARS-CoV‑2 Main Protease Inhibitors
Expedited Approach toward the Rational Design of Noncovalent SARS-CoV‑2 Main Protease Inhibitors
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Expedited Approach toward the Rational Design of Noncovalent SARS-CoV‑2 Main Protease Inhibitors

Kitamura, Naoya ; Sacco, Michael Dominic ; Ma, Chunlong ; Hu, Yanmei ; Townsend, Julia Alma ; Meng, Xiangzhi ; Zhang, Fushun ; Zhang, Xiujun ; Ba, Mandy ; Szeto, Tommy ; Kukuljac, Adis ; Marty, Michael Thomas ; Schultz, David ; Cherry, Sara ; Xiang, Yan ; Chen, Yu ; Wang, Jun

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2848-2865 [Periódico revisado por pares]

United States: American Chemical Society

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