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The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance
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The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance

Hsiou, Yu ; Ding, Jianping ; Das, Kalyan ; Clark, Arthur D ; Boyer, Paul L ; Lewi, Paul ; Janssen, Paul A.J ; Kleim, Jörg-Peter ; Rösner, Manfred ; Hughes, Stephen H ; Arnold, Edward

Journal of molecular biology, 2001-06, Vol.309 (2), p.437-445 [Periódico revisado por pares]

England: Elsevier Ltd

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2
Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097
Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097
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Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097

Das, Kalyan ; Sarafianos, Stefan G. ; Clark, Arthur D. ; Boyer, Paul L. ; Hughes, Stephen H. ; Arnold, Eddy

Journal of molecular biology, 2007-01, Vol.365 (1), p.77-89 [Periódico revisado por pares]

England: Elsevier Ltd

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3
Fixed Conformation Nucleoside Analogs Effectively Inhibit Excision-proficient HIV-1 Reverse Transcriptases
Fixed Conformation Nucleoside Analogs Effectively Inhibit Excision-proficient HIV-1 Reverse Transcriptases
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Fixed Conformation Nucleoside Analogs Effectively Inhibit Excision-proficient HIV-1 Reverse Transcriptases

Boyer, Paul L. ; Julias, John G. ; Marquez, Victor E. ; Hughes, Stephen H.

Journal of molecular biology, 2005-01, Vol.345 (3), p.441-450 [Periódico revisado por pares]

England: Elsevier Ltd

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4
The Nucleoside Analogs 4′C-Methyl Thymidine and 4′C-Ethyl Thymidine Block DNA Synthesis by Wild-type HIV-1 RT and Excision Proficient NRTI Resistant RT Variants
The Nucleoside Analogs 4′C-Methyl Thymidine and 4′C-Ethyl Thymidine Block DNA Synthesis by Wild-type HIV-1 RT and Excision Proficient NRTI Resistant RT Variants
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The Nucleoside Analogs 4′C-Methyl Thymidine and 4′C-Ethyl Thymidine Block DNA Synthesis by Wild-type HIV-1 RT and Excision Proficient NRTI Resistant RT Variants

Boyer, Paul L. ; Julias, John G. ; Ambrose, Zandrea ; Siddiqui, Maqbool A. ; Marquez, Victor E. ; Hughes, Stephen H.

Journal of molecular biology, 2007-08, Vol.371 (4), p.873-882 [Periódico revisado por pares]

Elsevier Ltd

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5
The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase
The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase
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The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase

Gao, H Q ; Boyer, P L ; Sarafianos, S G ; Arnold, E ; Hughes, S H

Journal of molecular biology, 2000-07, Vol.300 (2), p.403-418 [Periódico revisado por pares]

England

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6
Locations of Anti-AIDS Drug Binding Sites and Resistance Mutations in the Three-dimensional Structure of HIV-1 Reverse Transcriptase: Implications for Mechanisms of Drug Inhibition and Resistance
Locations of Anti-AIDS Drug Binding Sites and Resistance Mutations in the Three-dimensional Structure of HIV-1 Reverse Transcriptase: Implications for Mechanisms of Drug Inhibition and Resistance
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Locations of Anti-AIDS Drug Binding Sites and Resistance Mutations in the Three-dimensional Structure of HIV-1 Reverse Transcriptase: Implications for Mechanisms of Drug Inhibition and Resistance

Tantillo, Chris ; Ding, Jianping ; Jacobo-Molina, Alfredo ; Nanni, Raymond G. ; Boyer, Paul L. ; Hughes, Stephen H. ; Pauwels, Rudi ; Andries, Koen ; Janssen, Paul A.J. ; Arnold, Edward

Journal of Molecular Biology, 1994, Vol.243 (3), p.369-387 [Periódico revisado por pares]

England: Elsevier Ltd

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7
Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant
Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant
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Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant

Das, Kalyan ; Ding, Jianping ; Hsiou, Yu ; Clark, Arthur D. ; Moereels, Henri ; Koymans, Luc ; Andries, Koen ; Pauwels, Rudi ; Janssen, Paul A.J. ; Boyer, Paul L. ; Clark, Patrick ; Smith, Richard H. ; Kroeger Smith, Marilyn B. ; Michejda, Christopher J. ; Hughes, Stephen H. ; Arnold, Edward

Journal of molecular biology, 1996-12, Vol.264 (5), p.1085-1100 [Periódico revisado por pares]

England: Elsevier Ltd

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8
The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase 1 1Edited by A. R. Fersht
The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase 1 1Edited by A. R. Fersht
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The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase 1 1Edited by A. R. Fersht

Gao, Hong-Qiang ; Boyer, Paul L ; Sarafianos, Stefan G ; Arnold, Edward ; Hughes, Stephen H

Journal of molecular biology, 2000-07, Vol.300 (2), p.403-418 [Periódico revisado por pares]

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9
Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097
Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097
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Artigo 		Adicionar ao Meu Espaço

Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097

Das, Kalyan ; Sarafianos, Stefan G ; Clark, Arthur D ; Boyer, Paul L ; Hughes, Stephen H ; Arnold, Eddy

Journal of Molecular Biology, 2007-01, Vol.365 (1), p.77-89 [Periódico revisado por pares]

Academic Press

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10
Effects of mutations in the polymerase domain on the polymerase, RNase H and strand transfer activities of human immunodeficiency virus type 1 reverse transcriptase
Effects of mutations in the polymerase domain on the polymerase, RNase H and strand transfer activities of human immunodeficiency virus type 1 reverse transcriptase
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Effects of mutations in the polymerase domain on the polymerase, RNase H and strand transfer activities of human immunodeficiency virus type 1 reverse transcriptase

Gao, H Q ; Boyer, P L ; Arnold, E ; Hughes, S H

Journal of molecular biology, 1998-04, Vol.277 (3), p.559-572 [Periódico revisado por pares]

England

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