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1
DFG‑1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity
DFG‑1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity
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DFG‑1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity

Schröder, Martin ; Bullock, Alex N ; Fedorov, Oleg ; Bracher, Franz ; Chaikuad, Apirat ; Knapp, Stefan

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10224-10234 [Periódico revisado por pares]

United States: American Chemical Society

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2
Targeting low-druggability bromodomains fragment based screening and inhibitor design against the BAZ2B bromodomain
Targeting low-druggability bromodomains fragment based screening and inhibitor design against the BAZ2B bromodomain
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Targeting low-druggability bromodomains fragment based screening and inhibitor design against the BAZ2B bromodomain

Fleur M. Ferguson Oleg Fedorov; Apirat Chaikuad; Martin Philpott; João Renato Carvalho Muniz; Ildiko Felletar; Frank von Delft; Tom Heightman; Stefan Knapp; Chris Abell; Alessio Ciulli

Journal of Medicinal Chemistry Washington, DC : American Chemical Society - ACS v. 56, n. 24, p. 10183-10187, Dec. 2013

Washington, DC 2013

Localização: IFSC - Inst. Física de São Carlos    (PROD021601 )(Acessar)

3
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL)
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL)
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Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL)

Heidenreich, David ; Moustakim, Moses ; Schmidt, Jurema ; Merk, Daniel ; Brennan, Paul E ; Fedorov, Oleg ; Chaikuad, Apirat ; Knapp, Stefan

Journal of medicinal chemistry, 2018-12, Vol.61 (23), p.10929-10934 [Periódico revisado por pares]

United States: American Chemical Society

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4
Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors
Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors
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Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors

Popp, Tobias A ; Tallant, Cynthia ; Rogers, Catherine ; Fedorov, Oleg ; Brennan, Paul E ; Müller, Susanne ; Knapp, Stefan ; Bracher, Franz

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.8889-8912 [Periódico revisado por pares]

United States: American Chemical Society

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5
Discovery of (2S,3R)‑N‑[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a Selective α7 Nicotinic Acetylcholine Receptor Agonist, for the Treatment of Cognitive Disorders
Discovery of (2S,3R)‑N‑[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a Selective α7 Nicotinic Acetylcholine Receptor Agonist, for the Treatment of Cognitive Disorders
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Discovery of (2S,3R)‑N‑[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a Selective α7 Nicotinic Acetylcholine Receptor Agonist, for the Treatment of Cognitive Disorders

Mazurov, Anatoly A ; Kombo, David C ; Hauser, Terry A ; Miao, Lan ; Dull, Gary ; Genus, John F ; Fedorov, Nikolai B ; Benson, Lisa ; Sidach, Serguei ; Xiao, Yunde ; Hammond, Philip S ; James, John W ; Miller, Craig H ; Yohannes, Daniel

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.9793-9809 [Periódico revisado por pares]

United States: American Chemical Society

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6
Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models
Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models
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Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models

Hudkins, Robert L ; Diebold, James L ; Tao, Ming ; Josef, Kurt A ; Park, Chung Ho ; Angeles, Thelma S ; Aimone, Lisa D ; Husten, Jean ; Ator, Mark A ; Meyer, Sheryl L ; Holskin, Beverly P ; Durkin, John T ; Fedorov, Alexander A ; Fedorov, Elena V ; Almo, Steven C ; Mathiasen, Joanne R ; Bozyczko-Coyne, Donna ; Saporito, Michael S ; Scott, Richard W ; Mallamo, John P

Journal of medicinal chemistry, 2008-09, Vol.51 (18), p.5680-5689 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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7
Structure–Activity Studies of 7‑Heteroaryl-3-azabicyclo[3.3.1]non-6-enes: A Novel Class of Highly Potent Nicotinic Receptor Ligands
Structure–Activity Studies of 7‑Heteroaryl-3-azabicyclo[3.3.1]non-6-enes: A Novel Class of Highly Potent Nicotinic Receptor Ligands
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Structure–Activity Studies of 7‑Heteroaryl-3-azabicyclo[3.3.1]non-6-enes: A Novel Class of Highly Potent Nicotinic Receptor Ligands

Breining, Scott R ; Melvin, Matt ; Bhatti, Balwinder S ; Byrd, Gary D ; Kiser, Melanie N ; Hepler, Christopher D ; Hooker, Dawn N ; Zhang, Jenny ; Reynolds, Leslie A ; Benson, Lisa R ; Fedorov, Nikolai B ; Sidach, Serguei S ; Mitchener, J. Pike ; Lucero, Linda M ; Lukas, Ronald J ; Whiteaker, Paul ; Yohannes, Daniel

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.9929-9945 [Periódico revisado por pares]

United States: American Chemical Society

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8
Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain
Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain
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Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain

Chaikuad, A. ; Lang, S. ; Brennan, P.E. ; Temperini, C. ; Fedorov, O. ; Hollander, J. ; Nachane, R. ; Abell, C. ; Muller, S. ; Siegal, G.D.

Journal of medicinal chemistry, 2016, Vol.59 (4), p.1648-1653

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9
Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach
Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach
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Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

Hoffer, Laurent ; Voitovich, Yuliia V ; Raux, Brigitt ; Carrasco, Kendall ; Muller, Christophe ; Fedorov, Aleksey Y ; Derviaux, Carine ; Amouric, Agnès ; Betzi, Stéphane ; Horvath, Dragos ; Varnek, Alexandre ; Collette, Yves ; Combes, Sébastien ; Roche, Philippe ; Morelli, Xavier

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5719-5732 [Periódico revisado por pares]

United States: American Chemical Society

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10
Structural Basis of Inhibitor Specificity of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM-1) Kinase
Structural Basis of Inhibitor Specificity of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM-1) Kinase
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Structural Basis of Inhibitor Specificity of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM-1) Kinase

Bullock, Alex N ; Debreczeni, Judit É ; Fedorov, Oleg Y ; Nelson, Adam ; Marsden, Brian D ; Knapp, Stefan

Journal of medicinal chemistry, 2005-12, Vol.48 (24), p.7604-7614 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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Deste Autor:

  1. Fedorov, O
  2. Felletar, I
  3. Abell, C
  4. Heightman, T
  5. Philpott, M

Neste Assunto:

  1. Life Sciences & Biomedicine
  2. Pharmacology & Pharmacy
  3. Science & Technology
  4. Chemistry, Medicinal
  5. Humans

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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