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RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?
RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?
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RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?

Downward, Julian

Clinical cancer research, 2015-04, Vol.21 (8), p.1802-1809 [Periódico revisado por pares]

United States

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2
The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma
The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma
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The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

Miess, Heike ; Dankworth, Beatrice ; Gouw, Arvin M ; Rosenfeldt, Mathias ; Schmitz, Werner ; Jiang, Ming ; Saunders, Becky ; Howell, Michael ; Downward, Julian ; Felsher, Dean W ; Peck, Barrie ; Schulze, Almut

Oncogene, 2018-10, Vol.37 (40), p.5435-5450 [Periódico revisado por pares]

England: Nature Publishing Group

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3
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

Coppé, Jean-Philippe ; Patil, Christopher K ; Rodier, Francis ; Sun, Yu ; Muñoz, Denise P ; Goldstein, Joshua ; Nelson, Peter S ; Desprez, Pierre-Yves ; Campisi, Judith Downward, Julian

PLoS biology, 2008-12, Vol.6 (12), p.2853-e301 [Periódico revisado por pares]

United States: Public Library of Science

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4
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA
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Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

Coelho, Matthew A. ; de Carné Trécesson, Sophie ; Rana, Sareena ; Zecchin, Davide ; Moore, Christopher ; Molina-Arcas, Miriam ; East, Philip ; Spencer-Dene, Bradley ; Nye, Emma ; Barnouin, Karin ; Snijders, Ambrosius P. ; Lai, Wi S. ; Blackshear, Perry J. ; Downward, Julian

Immunity (Cambridge, Mass.), 2017-12, Vol.47 (6), p.1083-1099.e6 [Periódico revisado por pares]

United States: Elsevier Inc

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5
HMGA2 functions as a competing endogenous RNA to promote lung cancer progression
HMGA2 functions as a competing endogenous RNA to promote lung cancer progression
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HMGA2 functions as a competing endogenous RNA to promote lung cancer progression

Kumar, Madhu S ; Armenteros-Monterroso, Elena ; East, Philip ; Chakravorty, Probir ; Matthews, Nik ; Winslow, Monte M ; Downward, Julian

Nature (London), 2014-01, Vol.505 (7482), p.212-217 [Periódico revisado por pares]

England: Nature Publishing Group

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6
Drugging the Undruggable: Advances on RAS Targeting in Cancer
Drugging the Undruggable: Advances on RAS Targeting in Cancer
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Drugging the Undruggable: Advances on RAS Targeting in Cancer

Molina-Arcas, Miriam ; Samani, Amit ; Downward, Julian

Genes, 2021-06, Vol.12 (6), p.899 [Periódico revisado por pares]

Switzerland: MDPI AG

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7
Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer
Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer
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Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer

Molina-Arcas, Miriam ; Moore, Christopher ; Rana, Sareena ; van Maldegem, Febe ; Mugarza, Edurne ; Romero-Clavijo, Pablo ; Herbert, Eleanor ; Horswell, Stuart ; Li, Lian-Sheng ; Janes, Matthew R ; Hancock, David C ; Downward, Julian

Science translational medicine, 2019-09, Vol.11 (510), p.1 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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8
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Gerlinger, Marco ; Rowan, Andrew J ; Horswell, Stuart ; Larkin, James ; Endesfelder, David ; Gronroos, Eva ; Martinez, Pierre ; Matthews, Nicholas ; Stewart, Aengus ; Tarpey, Patrick ; Varela, Ignacio ; Phillimore, Benjamin ; Begum, Sharmin ; McDonald, Neil Q ; Butler, Adam ; Jones, David ; Raine, Keiran ; Latimer, Calli ; Santos, Claudio R ; Nohadani, Mahrokh ; Eklund, Aron C ; Spencer-Dene, Bradley ; Clark, Graham ; Pickering, Lisa ; Stamp, Gordon ; Gore, Martin ; Szallasi, Zoltan ; Downward, Julian ; Futreal, P. Andrew ; Swanton, Charles

The New England journal of medicine, 2012-03, Vol.366 (10), p.883-892 [Periódico revisado por pares]

Waltham, MA: Massachusetts Medical Society

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9
Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies
Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies
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Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

Steckel, Michael ; Molina-Arcas, Miriam ; Weigelt, Britta ; Marani, Michaela ; Warne, Patricia H ; Kuznetsov, Hanna ; Kelly, Gavin ; Saunders, Becky ; Howell, Michael ; Downward, Julian ; Hancock, David C

Cell research, 2012-08, Vol.22 (8), p.1227-1245 [Periódico revisado por pares]

England: Nature Publishing Group

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10
RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms
RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms
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RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

Fritsch, Ralph ; de Krijger, Inge ; Fritsch, Kornelia ; George, Roger ; Reason, Beth ; Kumar, Madhu S. ; Diefenbacher, Markus ; Stamp, Gordon ; Downward, Julian

Cell, 2013-05, Vol.153 (5), p.1050-1063 [Periódico revisado por pares]

United States: Elsevier Inc

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