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From genome to function by studying eQTLs
From genome to function by studying eQTLs
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From genome to function by studying eQTLs

Westra, Harm-Jan ; Franke, Lude

Biochimica et biophysica acta. Molecular basis of disease, 2014-10, Vol.1842 (10), p.1896-1902 [Periódico revisado por pares]

Elsevier B.V

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Biological interpretation of genome-wide association studies using predicted gene functions
Biological interpretation of genome-wide association studies using predicted gene functions
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Biological interpretation of genome-wide association studies using predicted gene functions

Pers, Tune H ; Karjalainen, Juha M ; Chan, Yingleong ; Westra, Harm-Jan ; Wood, Andrew R ; Yang, Jian ; Lui, Julian C ; Vedantam, Sailaja ; Gustafsson, Stefan ; Esko, Tonu ; Frayling, Tim ; Speliotes, Elizabeth K ; Boehnke, Michael ; Raychaudhuri, Soumya ; Fehrmann, Rudolf S N ; Hirschhorn, Joel N ; Franke, Lude

Nature communications, 2015-01, Vol.6 (1), p.5890-5890, Article 5890 [Periódico revisado por pares]

England: Nature Publishing Group

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3
Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids
Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids
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Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids

van der Graaf, Adriaan ; Claringbould, Annique ; Rimbert, Antoine ; Heijmans, Bastiaan T. ; Hoen, Peter A. C.’t ; van Meurs, Joyce B. J. ; Jansen, Rick ; Franke, Lude ; Westra, Harm-Jan ; Li, Yang ; Wijmenga, Cisca ; Sanna, Serena

Nature communications, 2020-10, Vol.11 (1), p.4930-4930, Article 4930 [Periódico revisado por pares]

London: Nature Publishing Group

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4
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes
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Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes

Westra, Harm-Jan ; Martínez-Bonet, Marta ; Onengut-Gumuscu, Suna ; Lee, Annette ; Luo, Yang ; Teslovich, Nikola ; Worthington, Jane ; Martin, Javier ; Huizinga, Tom ; Klareskog, Lars ; Rantapaa-Dahlqvist, Solbritt ; Chen, Wei-Min ; Quinlan, Aaron ; Todd, John A ; Eyre, Steve ; Nigrovic, Peter A ; Gregersen, Peter K ; Rich, Stephen S ; Raychaudhuri, Soumya

Nature genetics, 2018-10, Vol.50 (10), p.1366-1374 [Periódico revisado por pares]

United States: Nature Publishing Group

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5
Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells
Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells
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Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells

Kasela, Silva ; Kisand, Kai ; Tserel, Liina ; Kaleviste, Epp ; Remm, Anu ; Fischer, Krista ; Esko, Tõnu ; Westra, Harm-Jan ; Fairfax, Benjamin P ; Makino, Seiko ; Knight, Julian C ; Franke, Lude ; Metspalu, Andres ; Peterson, Pärt ; Milani, Lili Lappalainen, Tuuli

PLoS genetics, 2017-03, Vol.13 (3), p.e1006643-e1006643 [Periódico revisado por pares]

United States: Public Library of Science

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6
Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure
Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure
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Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure

Oelen, Roy ; de Vries, Dylan H ; Brugge, Harm ; Gordon, M Grace ; Vochteloo, Martijn ; Ye, Chun J ; Westra, Harm-Jan ; Franke, Lude ; van der Wijst, Monique G P

Nature communications, 2022-06, Vol.13 (1), p.3267-3267, Article 3267 [Periódico revisado por pares]

England: Nature Publishing Group

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7
IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors
IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors
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IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors

Amariuta, Tiffany ; Luo, Yang ; Gazal, Steven ; Davenport, Emma E. ; van de Geijn, Bryce ; Ishigaki, Kazuyoshi ; Westra, Harm-Jan ; Teslovich, Nikola ; Okada, Yukinori ; Yamamoto, Kazuhiko ; Price, Alkes L. ; Raychaudhuri, Soumya

American journal of human genetics, 2019-05, Vol.104 (5), p.879-895 [Periódico revisado por pares]

United States: Elsevier Inc

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8
Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease
Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease
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Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease

Hu, Shixian ; Uniken Venema, Werna T ; Westra, Harm-Jan ; Vich Vila, Arnau ; Barbieri, Ruggero ; Voskuil, Michiel D ; Blokzijl, Tjasso ; Jansen, Bernadien H ; Li, Yanni ; Daly, Mark J ; Xavier, Ramnik J ; Dijkstra, Gerard ; Festen, Eleonora A ; Weersma, Rinse K

Nature communications, 2021-02, Vol.12 (1), p.1122-1122, Article 1122 [Periódico revisado por pares]

England: Nature Publishing Group

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9
PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs
PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs
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PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs

Vochteloo, Martijn ; Deelen, Patrick ; Vink, Britt ; Tsai, Ellen A ; Runz, Heiko ; Andreu-Sánchez, Sergio ; Fu, Jingyuan ; Zhernakova, Alexandra ; Westra, Harm-Jan ; Franke, Lude

Genome Biology, 2024-01, Vol.25 (1), p.29-26, Article 29 [Periódico revisado por pares]

England: BioMed Central

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10
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression
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Human disease-associated genetic variation impacts large intergenic non-coding RNA expression

Kumar, Vinod ; Westra, Harm-Jan ; Karjalainen, Juha ; Zhernakova, Daria V ; Esko, Tõnu ; Hrdlickova, Barbara ; Almeida, Rodrigo ; Zhernakova, Alexandra ; Reinmaa, Eva ; Võsa, Urmo ; Hofker, Marten H ; Fehrmann, Rudolf S N ; Fu, Jingyuan ; Withoff, Sebo ; Metspalu, Andres ; Franke, Lude ; Wijmenga, Cisca Cheung, Vivian G.

PLoS genetics, 2013-01, Vol.9 (1), p.e1003201 [Periódico revisado por pares]

United States: Public Library of Science

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