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Refinado por: Nome da Publicação: Journal Of Medicinal Chemistry remover
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1
Complexity of Blocking Bivalent Protein–Protein Interactions: Development of a Highly Potent Inhibitor of the Menin–Mixed-Lineage Leukemia Interaction
Complexity of Blocking Bivalent Protein–Protein Interactions: Development of a Highly Potent Inhibitor of the Menin–Mixed-Lineage Leukemia Interaction
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Complexity of Blocking Bivalent Protein–Protein Interactions: Development of a Highly Potent Inhibitor of the Menin–Mixed-Lineage Leukemia Interaction

Borkin, Dmitry ; Klossowski, Szymon ; Pollock, Jonathan ; Miao, Hongzhi ; Linhares, Brian M ; Kempinska, Katarzyna ; Jin, Zhuang ; Purohit, Trupta ; Wen, Bo ; He, Miao ; Sun, Duxin ; Cierpicki, Tomasz ; Grembecka, Jolanta

Journal of medicinal chemistry, 2018-06, Vol.61 (11), p.4832-4850 [Periódico revisado por pares]

United States: American Chemical Society

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2
Identification of Thiourea-Based Inhibitors of the B‑Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design
Identification of Thiourea-Based Inhibitors of the B‑Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design
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Identification of Thiourea-Based Inhibitors of the B‑Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design

Cheng, Huimin ; Linhares, Brian M ; Yu, Wenbo ; Cardenas, Mariano G ; Ai, Yong ; Jiang, Wenjuan ; Winkler, Alyssa ; Cohen, Sandra ; Melnick, Ari ; MacKerell, Alexander ; Cierpicki, Tomasz ; Xue, Fengtian

Journal of medicinal chemistry, 2018-09, Vol.61 (17), p.7573-7588 [Periódico revisado por pares]

United States: American Chemical Society

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3
A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models:  6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and Congeners
A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models:  6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and Congeners
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A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models:  6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and Congeners

Mylari, Banavara L ; Armento, Sandra J ; Beebe, David A ; Conn, Edward L ; Coutcher, James B ; Dina, Michael S ; O'Gorman, Melissa T ; Linhares, Michael C ; Martin, William H ; Oates, Peter J ; Tess, David A ; Withbroe, Gregory J ; Zembrowski, William J

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6326-6339 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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4
Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 (BCL6) BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design
Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 (BCL6) BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design
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Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 (BCL6) BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design

Cheng, Huimin ; Linhares, Brian M. ; Yu, Wenbo ; Cardenas, Mariano G. ; Ai, Yong ; Jiang, Wenjuan ; Winkler, Alyssa ; Cohen, Sandra ; Melnick, Ari ; MacKerell, Alexander ; Cierpicki, Tomasz ; Xue, Fengtian

Journal of medicinal chemistry, 2018-07, Vol.61 (17), p.7573-7588 [Periódico revisado por pares]

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5
A Highly Selective, Non-Hydantoin, Non-Carboxylic Acid Inhibitor of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models:  6-(5-Chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one
A Highly Selective, Non-Hydantoin, Non-Carboxylic Acid Inhibitor of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models:  6-(5-Chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one
Material Type:
Artigo 		Adicionar ao Meu Espaço

A Highly Selective, Non-Hydantoin, Non-Carboxylic Acid Inhibitor of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models:  6-(5-Chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one

Mylari, Banavara L ; Armento, Sandra J ; Beebe, David A ; Conn, Edward L ; Coutcher, James B ; Dina, Michael S ; O'Gorman, Melissa T ; Linhares, Michael C ; Martin, William H ; Oates, Peter J ; Tess, David A ; Withbroe, Gregory J ; Zembrowski, William J

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2283-2286 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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6
A Sorbitol Dehydrogenase Inhibitor of Exceptional in Vivo Potency with a Long Duration of Action:  1-(R)-{4-[4-(4,6-Dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl}ethanol
A Sorbitol Dehydrogenase Inhibitor of Exceptional in Vivo Potency with a Long Duration of Action:  1-(R)-{4-[4-(4,6-Dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl}ethanol
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A Sorbitol Dehydrogenase Inhibitor of Exceptional in Vivo Potency with a Long Duration of Action:  1-(R)-{4-[4-(4,6-Dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl}ethanol

Mylari, Banavara L ; Oates, Peter J ; Zembrowski, William J ; Beebe, David A ; Conn, Edward L ; Coutcher, James B ; O'Gorman, Melissa T ; Linhares, Michael C ; Withbroe, Gregory J

Journal of medicinal chemistry, 2002-09, Vol.45 (20), p.4398-4401 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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