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Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N -Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile
Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N -Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile
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Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N -Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile

Makhaeva, Galina F ; Kovaleva, Nadezhda V ; Boltneva, Natalia P ; Rudakova, Elena V ; Lushchekina, Sofya V ; Astakhova, Tatiana Yu ; Serkov, Igor V ; Proshin, Alexey N ; Radchenko, Eugene V ; Palyulin, Vladimir A ; Korabecny, Jan ; Soukup, Ondrej ; Bachurin, Sergey O ; Richardson, Rudy J

Molecules (Basel, Switzerland), 2022-02, Vol.27 (3), p.1060 [Periódico revisado por pares]

Switzerland: MDPI AG

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2
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
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7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment

Korabecny, Jan ; Andrs, Martin ; Nepovimova, Eugenie ; Dolezal, Rafael ; Babkova, Katerina ; Horova, Anna ; Malinak, David ; Mezeiova, Eva ; Gorecki, Lukas ; Sepsova, Vendula ; Hrabinova, Martina ; Soukup, Ondrej ; Jun, Daniel ; Kuca, Kamil

Molecules (Basel, Switzerland), 2015-12, Vol.20 (12), p.22084-22101 [Periódico revisado por pares]

Switzerland: MDPI AG

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3
Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study
Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study
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Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study

Sepsova, Vendula ; Karasova, Jana Zdarova ; Korabecny, Jan ; Dolezal, Rafael ; Zemek, Filip ; Bennion, Brian J ; Kuca, Kamil

International journal of molecular sciences, 2013-08, Vol.14 (8), p.16882-16900 [Periódico revisado por pares]

Switzerland: MDPI AG

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4
SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides
SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides
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SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides

Gorecki, Lukas ; Korabecny, Jan ; Musilek, Kamil ; Malinak, David ; Nepovimova, Eugenie ; Dolezal, Rafael ; Jun, Daniel ; Soukup, Ondrej ; Kuca, Kamil

Archives of toxicology, 2016-12, Vol.90 (12), p.2831-2859 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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5
Synthesis and Biological Evaluation of Novel Tacrine Derivatives and Tacrine–Coumarin Hybrids as Cholinesterase Inhibitors
Synthesis and Biological Evaluation of Novel Tacrine Derivatives and Tacrine–Coumarin Hybrids as Cholinesterase Inhibitors
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Synthesis and Biological Evaluation of Novel Tacrine Derivatives and Tacrine–Coumarin Hybrids as Cholinesterase Inhibitors

Hamulakova, Slavka ; Janovec, Ladislav ; Hrabinova, Martina ; Spilovska, Katarina ; Korabecny, Jan ; Kristian, Pavol ; Kuca, Kamil ; Imrich, Jan

Journal of medicinal chemistry, 2014-08, Vol.57 (16), p.7073-7084 [Periódico revisado por pares]

United States: American Chemical Society

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6
Profiling donepezil template into multipotent hybrids with antioxidant properties
Profiling donepezil template into multipotent hybrids with antioxidant properties
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Profiling donepezil template into multipotent hybrids with antioxidant properties

Mezeiova, Eva ; Spilovska, Katarina ; Nepovimova, Eugenie ; Gorecki, Lukas ; Soukup, Ondrej ; Dolezal, Rafael ; Malinak, David ; Janockova, Jana ; Jun, Daniel ; Kuca, Kamil ; Korabecny, Jan

Journal of enzyme inhibition and medicinal chemistry, 2018-01, Vol.33 (1), p.583-606 [Periódico revisado por pares]

England: Taylor & Francis

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7
Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation
Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation
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Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation

Spilovska, Katarina ; Korabecny, Jan ; Sepsova, Vendula ; Jun, Daniel ; Hrabinova, Martina ; Jost, Petr ; Muckova, Lubica ; Soukup, Ondrej ; Janockova, Jana ; Kucera, Tomas ; Dolezal, Rafael ; Mezeiova, Eva ; Kaping, Daniel ; Kuca, Kamil

Molecules (Basel, Switzerland), 2017-06, Vol.22 (6), p.1006 [Periódico revisado por pares]

Switzerland: MDPI AG

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8
Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study
Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study
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Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study

Maafi, Negar ; Pidaný, Filip ; Maříková, Jana ; Korábečný, Jan ; Hulcová, Daniela ; Kučera, Tomáš ; Schmidt, Monika ; Shammari, Latifah Al ; Špulák, Marcel ; Carmen Catapano, Maria ; Mecava, Marko ; Prchal, Lukáš ; Kuneš, Jiří ; Janoušek, Jiří ; Kohelová, Eliška ; Jenčo, Jaroslav ; Nováková, Lucie ; Cahlíková, Lucie

Bioorganic & medicinal chemistry letters, 2021-11, Vol.51, p.128374, Article 128374 [Periódico revisado por pares]

England: Elsevier Ltd

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9
Synthesis, inhibition studies against AChE and BChE, drug-like profiling, kinetic analysis and molecular docking studies of N-(4-phenyl-3-aroyl-2(3H)-ylidene) substituted acetamides
Synthesis, inhibition studies against AChE and BChE, drug-like profiling, kinetic analysis and molecular docking studies of N-(4-phenyl-3-aroyl-2(3H)-ylidene) substituted acetamides
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Synthesis, inhibition studies against AChE and BChE, drug-like profiling, kinetic analysis and molecular docking studies of N-(4-phenyl-3-aroyl-2(3H)-ylidene) substituted acetamides

Larik, Fayaz Ali ; Saeed, Aamer ; Faisal, Muhammad ; Hamdani, Salma ; Jabeen, Farukh ; Channar, Pervaiz Ali ; Mumtaz, Amara ; Khan, Imtiaz ; Kazi, Mahar Ali ; Abbas, Qamar ; Hassan, Mubashir ; Korabecny, Jan ; Seo, Sung-Yum

Journal of molecular structure, 2020-03, Vol.1203, p.127459, Article 127459 [Periódico revisado por pares]

Elsevier B.V

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10
Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation
Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation
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Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation

Pidany, Filip ; Kroustkova, Jana ; Al Mamun, Abdullah ; Suchankova, Daniela ; Brazzolotto, Xavier ; Nachon, Florian ; Chantegreil, Fabien ; Dolezal, Rafael ; Pulkrabkova, Lenka ; Muckova, Lubica ; Hrabinova, Martina ; Finger, Vladimir ; Kufa, Martin ; Soukup, Ondrej ; Jun, Daniel ; Jenco, Jaroslav ; Kunes, Jiri ; Novakova, Lucie ; Korabecny, Jan ; Cahlikova, Lucie

European journal of medicinal chemistry, 2023-04, Vol.252, p.115301-115301, Article 115301 [Periódico revisado por pares]

France: Elsevier Masson SAS

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