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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man
Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man
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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man

Gotter, Anthony L ; Forman, Mark S ; Harrell, Charles M ; Stevens, Joanne ; Svetnik, Vladimir ; Yee, Ka Lai ; Li, Xiaodong ; Roecker, Anthony J ; Fox, Steven V ; Tannenbaum, Pamela L ; Garson, Susan L ; Lepeleire, Inge De ; Calder, Nicole ; Rosen, Laura ; Struyk, Arie ; Coleman, Paul J ; Herring, W Joseph ; Renger, John J ; Winrow, Christopher J

Scientific reports, 2016-06, Vol.6 (1), p.27147, Article 27147 [Periódico revisado por pares]

England: Nature Publishing Group

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2
Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia
Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia
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Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia

Winrow, Christopher J. ; Gotter, Anthony L. ; Cox, Christopher D. ; Tannenbaum, Pamela L. ; Garson, Susan L. ; Doran, Scott M. ; Breslin, Michael J. ; Schreier, John D. ; Fox, Steven V. ; Harrell, Charles M. ; Stevens, Joanne ; Reiss, Duane R. ; Cui, Donghui ; Coleman, Paul J. ; Renger, John J.

Neuropharmacology, 2012-02, Vol.62 (2), p.978-987 [Periódico revisado por pares]

England: Elsevier Ltd

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3
Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys
Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys
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Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys

Tannenbaum, Pamela L ; Tye, Spencer J ; Stevens, Joanne ; Gotter, Anthony L ; Fox, Steven V ; Savitz, Alan T ; Coleman, Paul J ; Uslaner, Jason M ; Kuduk, Scott D ; Hargreaves, Richard ; Winrow, Christopher J ; Renger, John J

Sleep (New York, N.Y.), 2016-03, Vol.39 (3), p.603-612 [Periódico revisado por pares]

United States: Associated Professional Sleep Societies, LLC

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4
Promotion of Sleep by Suvorexant-A Novel Dual Orexin Receptor Antagonist
Promotion of Sleep by Suvorexant-A Novel Dual Orexin Receptor Antagonist
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Promotion of Sleep by Suvorexant-A Novel Dual Orexin Receptor Antagonist

Winrow, Christopher J. ; Gotter, Anthony L. ; Cox, Christopher D. ; Doran, Scott M. ; Tannenbaum, Pamela L. ; Breslin, Michael J. ; Garson, Susan L. ; Fox, Steven V. ; Harrell, Charles M. ; Stevens, Joanne ; Reiss, Duane R. ; Cui, Donghui ; Coleman, Paul J. ; Renger, John J.

Journal of neurogenetics, 2011-03, Vol.25 (1-2), p.52-61 [Periódico revisado por pares]

England: Informa Healthcare

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5
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold
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The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

Gotter, Anthony L ; Winrow, Christopher J ; Brunner, Joseph ; Garson, Susan L ; Fox, Steven V ; Binns, Jacquelyn ; Harrell, Charles M ; Cui, Donghui ; Yee, Ka Lai ; Stiteler, Mark ; Stevens, Joanne ; Savitz, Alan ; Tannenbaum, Pamela L ; Tye, Spencer J ; McDonald, Terrence ; Yao, Leon ; Kuduk, Scott D ; Uslaner, Jason ; Coleman, Paul J ; Renger, John J

BMC neuroscience, 2013-08, Vol.14 (1), p.90-90, Article 90 [Periódico revisado por pares]

England: BioMed Central Ltd

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6
Discovery of 5′′-Chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3′′-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia
Discovery of 5′′-Chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3′′-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia
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Discovery of 5′′-Chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3′′-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia

Roecker, Anthony J. ; Mercer, Swati P. ; Schreier, John D. ; Cox, Christopher D. ; Fraley, Mark E. ; Steen, Justin T. ; Lemaire, Wei ; Bruno, Joseph G. ; Harrell, C. Meacham ; Garson, Susan L. ; Gotter, Anthony L. ; Fox, Steven V. ; Stevens, Joanne ; Tannenbaum, Pamela L. ; Prueksaritanont, Thomayant ; Cabalu, Tamara D. ; Cui, Donghui ; Stellabott, Joyce ; Hartman, George D. ; Young, Steven D. ; Winrow, Christopher J. ; Renger, John J. ; Coleman, Paul J.

ChemMedChem, 2014-02, Vol.9 (2), p.311-322 [Periódico revisado por pares]

Weinheim: WILEY-VCH Verlag

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7
Discovery of MK-3697: A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia
Discovery of MK-3697: A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia
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Discovery of MK-3697: A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia

Roecker, Anthony J. ; Reger, Thomas S. ; Mattern, M. Christa ; Mercer, Swati P. ; Bergman, Jeffrey M. ; Schreier, John D. ; Cube, Rowena V. ; Cox, Christopher D. ; Li, Dansu ; Lemaire, Wei ; Bruno, Joseph G. ; Harrell, C. Meacham ; Garson, Susan L. ; Gotter, Anthony L. ; Fox, Steven V. ; Stevens, Joanne ; Tannenbaum, Pamela L. ; Prueksaritanont, Thomayant ; Cabalu, Tamara D. ; Cui, Donghui ; Stellabott, Joyce ; Hartman, George D. ; Young, Steven D. ; Winrow, Christopher J. ; Renger, John J. ; Coleman, Paul J.

Bioorganic & medicinal chemistry letters, 2014-10, Vol.24 (20), p.4884-4890 [Periódico revisado por pares]

England: Elsevier Ltd

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8
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists
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Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists

Skudlarek, Jason W. ; DiMarco, Christina N. ; Babaoglu, Kerim ; Roecker, Anthony J. ; Bruno, Joseph G. ; Pausch, Mark A. ; O'Brien, Julie A. ; Cabalu, Tamara D. ; Stevens, Joanne ; Brunner, Joseph ; Tannenbaum, Pamela L. ; Wuelfing, W. Peter ; Garson, Susan L. ; Fox, Steven V. ; Savitz, Alan T. ; Harrell, Charles M. ; Gotter, Anthony L. ; Winrow, Christopher J. ; Renger, John J. ; Kuduk, Scott D. ; Coleman, Paul J.

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (6), p.1364-1370 [Periódico revisado por pares]

England: Elsevier Ltd

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9
Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs
Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs
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Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs

Tannenbaum, Pamela L ; Stevens, Joanne ; Binns, Jacquelyn ; Savitz, Alan T ; Garson, Susan L ; Fox, Steven V ; Coleman, Paul ; Kuduk, Scott D ; Gotter, Anthony L ; Marino, Michael ; Tye, Spencer J ; Uslaner, Jason M ; Winrow, Christopher J ; Renger, John J

Frontiers in behavioral neuroscience, 2014-05, Vol.8, p.182-182 [Periódico revisado por pares]

Switzerland: Frontiers Research Foundation

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10
Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3)
Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3)
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Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3)

Coburn, Craig A. ; Luo, Yunfu ; Cui, Mingxiang ; Wang, Jiabing ; Soll, Richard ; Dong, Jingchao ; Hu, Bin ; Lyon, Michael A. ; Santarelli, Vincent P. ; Kraus, Richard L. ; Gregan, Yun ; Wang, Yi ; Fox, Steven V. ; Binns, Jacquelyn ; Doran, Scott M. ; Reiss, Duane R. ; Tannenbaum, Pamela L. ; Gotter, Anthony L. ; Meinke, Peter T. ; Renger, John J.

ChemMedChem, 2012-01, Vol.7 (1), p.123-133 [Periódico revisado por pares]

Weinheim: WILEY-VCH Verlag

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