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Inhibitors of SARS-CoV‑2 Entry: Current and Future Opportunities
Inhibitors of SARS-CoV‑2 Entry: Current and Future Opportunities
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Inhibitors of SARS-CoV‑2 Entry: Current and Future Opportunities

Xiu, Siyu ; Dick, Alexej ; Ju, Han ; Mirzaie, Sako ; Abdi, Fatemeh ; Cocklin, Simon ; Zhan, Peng ; Liu, Xinyong

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12256-12274 [Periódico revisado por pares]

United States: American Chemical Society

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Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV‑2 Main Protease Inhibitors with High Target Specificity
Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV‑2 Main Protease Inhibitors with High Target Specificity
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Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV‑2 Main Protease Inhibitors with High Target Specificity

Ma, Chunlong ; Xia, Zilei ; Sacco, Michael Dominic ; Hu, Yanmei ; Townsend, Julia Alma ; Meng, Xiangzhi ; Choza, Juliana ; Tan, Haozhou ; Jang, Janice ; Gongora, Maura V ; Zhang, Xiujun ; Zhang, Fushun ; Xiang, Yan ; Marty, Michael Thomas ; Chen, Yu ; Wang, Jun

Journal of the American Chemical Society, 2021-12, Vol.143 (49), p.20697-20709 [Periódico revisado por pares]

United States: American Chemical Society

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3
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L
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Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L

Sacco, Michael Dominic ; Ma, Chunlong ; Lagarias, Panagiotis ; Gao, Ang ; Townsend, Julia Alma ; Meng, Xiangzhi ; Dube, Peter ; Zhang, Xiujun ; Hu, Yanmei ; Kitamura, Naoya ; Hurst, Brett ; Tarbet, Bart ; Marty, Michael Thomas ; Kolocouris, Antonios ; Xiang, Yan ; Chen, Yu ; Wang, Jun

Science advances, 2020-12, Vol.6 (50) [Periódico revisado por pares]

United States

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4
Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells
Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells
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Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells

Matsuyama, Shutoku ; Shirato, Kazuya ; Kawase, Miyuki ; Terada, Yutaka ; Kawachi, Kengo ; Fukushi, Shuetsu ; Kamitani, Wataru Gallagher, Tom

Journal of virology, 2018-10, Vol.92 (19) [Periódico revisado por pares]

United States: American Society for Microbiology

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5
MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L
MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L
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MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L

Ma, Xinyu R. ; Alugubelli, Yugendar R. ; Ma, Yuying ; Vatansever, Erol C. ; Scott, Danielle A. ; Qiao, Yuchen ; Yu, Ge ; Xu, Shiqing ; Liu, Wenshe Ray

ChemMedChem, 2022-01, Vol.17 (1), p.e202100456-n/a [Periódico revisado por pares]

Germany: Wiley Subscription Services, Inc

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6
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
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Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

Zhao, Miao-Miao ; Yang, Wei-Li ; Yang, Fang-Yuan ; Zhang, Li ; Huang, Wei-Jin ; Hou, Wei ; Fan, Chang-Fa ; Jin, Rong-Hua ; Feng, Ying-Mei ; Wang, You-Chun ; Yang, Jin-Kui

Signal transduction and targeted therapy, 2021-03, Vol.6 (1), p.134-134, Article 134 [Periódico revisado por pares]

England: Nature Publishing Group

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7
Cathepsin L targeting in cancer treatment
Cathepsin L targeting in cancer treatment
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Cathepsin L targeting in cancer treatment

Sudhan, Dhivya R ; Siemann, Dietmar W

Pharmacology & therapeutics (Oxford), 2015-11, Vol.155, p.105-116 [Periódico revisado por pares]

England

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8
Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors
Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors
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Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors

Kuhn, Bernd ; Tichý, Michal ; Wang, Lingle ; Robinson, Shaughnessy ; Martin, Rainer E ; Kuglstatter, Andreas ; Benz, Jörg ; Giroud, Maude ; Schirmeister, Tanja ; Abel, Robert ; Diederich, François ; Hert, Jérôme

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2485-2497 [Periódico revisado por pares]

United States: American Chemical Society

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9
A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L
A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L
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A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L

Dana, Dibyendu ; Pathak, Sanjai K

Molecules (Basel, Switzerland), 2020-02, Vol.25 (3), p.698 [Periódico revisado por pares]

Switzerland: MDPI AG

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10
Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients
Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients
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Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients

Liu, Tianxiao ; Luo, Songyuan ; Libby, Peter ; Shi, Guo-Ping

Pharmacology & therapeutics (Oxford), 2020-09, Vol.213, p.107587-107587, Article 107587 [Periódico revisado por pares]

England: Elsevier Inc

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