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Monocyte-Derived Dendritic Cells from Patients with Dermatophytosis Restrict the Growth of Trichophyton rubrum and Induce CD4-T Cell Activation

Santiago, Karla ; Bomfim, Gisele Facholi ; Criado, Paulo Ricardo ; Almeida, Sandro Rogerio Neyrolles, Olivier (editor)

PLoS ONE, 2014, Vol.9(11) [Periódico revisado por pares]

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Título:
Monocyte-Derived Dendritic Cells from Patients with Dermatophytosis Restrict the Growth of Trichophyton rubrum and Induce CD4-T Cell Activation
Autor: Santiago, Karla ; Bomfim, Gisele Facholi ; Criado, Paulo Ricardo ; Almeida, Sandro Rogerio
Neyrolles, Olivier (editor)
Assuntos: Research Article ; Biology And Life Sciences ; Medicine And Health Sciences
É parte de: PLoS ONE, 2014, Vol.9(11)
Descrição: Dermatophytes are the most common agents of superficial mycoses that are caused by mold fungi. Trichophyton rubrum is the most common pathogen causing dermatophytosis. The immunology of dermatophytosis is currently poorly understood. Recently, our group investigated the interaction of T. rubrum conidia with peritoneal mouse macrophages. We found that macrophages phagocytose T. rubrum conidia resulted in a down-modulation of class II major histocompatibility complex (MHC) antigens and in the expression of co-stimulatory molecules. Furthermore, it induced the production of IL-10, and T. rubrum conidia differentiated into hyphae that grew and killed the macrophages after 8 hrs of culture. This work demonstrated that dendritic cells (DCs) and macrophages, from patients or normal individuals, avidly interact with pathogenic fungus T. rubrum . The dermatophyte has two major receptors on human monocyte-derived DC: DC-SIGN and mannose receptor. In contrast macrophage has only mannose...

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