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Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex

Wilson, F A ; O'Scalaidhe, S P ; Goldman-Rakic, P S

Proceedings of the National Academy of Sciences of the United States of America, 26 April 1994, Vol.91(9), pp.4009-13 [Periódico revisado por pares]

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  • Título:
    Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex
  • Autor: Wilson, F A ; O'Scalaidhe, S P ; Goldman-Rakic, P S
  • Assuntos: Cerebral Cortex -- Physiology ; Visual Pathways -- Physiology ; Gamma-Aminobutyric Acid -- Physiology
  • É parte de: Proceedings of the National Academy of Sciences of the United States of America, 26 April 1994, Vol.91(9), pp.4009-13
  • Descrição: The responses of putative gamma-aminobutyratergic interneurons (fast-spiking) and pyramidal (regular-spiking) cell pairs were compared in monkeys performing visual and memory-guided oculomotor tasks. Both fast- and regular-spiking neurons had similar receptive fields, indicating that gamma-aminobutyratergic interneurons carry a specific informational signal, as opposed to providing nonspecific modulation. However, the responses of the pairs were inverted and the timing of excitatory and inhibitory responses appeared to be phased, a property consistent with gamma-aminobutyrate-mediated shaping of receptive fields. These observations (i) provide evidence that interneurons and pyramidal cells can be differentiated in vivo and (ii) begin to elucidate the role of gamma-aminobutyratergic mechanisms in cognition.
  • Idioma: Inglês

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