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The transcriptional regulators SteA and StuA contribute to keratin degradation and sexual reproduction of the dermatophyte Arthroderma benhamiae

Kröber, Antje ; Etzrodt, Sandra ; Bach, Maria ; Monod, Michel ; Kniemeyer, Olaf ; Staib, Peter ; Brakhage, Axel A

Current genetics, February 2017, Vol.63(1), pp.103-116 [Periódico revisado por pares]

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  • Título:
    The transcriptional regulators SteA and StuA contribute to keratin degradation and sexual reproduction of the dermatophyte Arthroderma benhamiae
  • Autor: Kröber, Antje ; Etzrodt, Sandra ; Bach, Maria ; Monod, Michel ; Kniemeyer, Olaf ; Staib, Peter ; Brakhage, Axel A
  • Assuntos: Arthroderma ; Dermatophyte ; Development ; Stea ; Stua ; Virulence ; Arthrodermataceae -- Physiology ; Fungal Proteins -- Metabolism ; Keratins -- Metabolism ; Transcription Factors -- Metabolism
  • É parte de: Current genetics, February 2017, Vol.63(1), pp.103-116
  • Descrição: Most superficial fungal infections are caused by dermatophytes, a specialized group of filamentous fungi which exclusively infect keratinized host structures such as hair, skin and nails. Since little is known about the molecular basis of pathogenicity and sexual reproduction in dermatophytes, here we functionally addressed two central transcriptional regulators, SteA and StuA. In the zoophilic species Arthroderma benhamiae a strategy for targeted genetic manipulation was recently established, and moreover, the species is teleomorphic and thus allows performing assays based on mating. By comparative genome analysis homologs of the developmental regulators SteA and StuA were identified in A. benhamiae. Knock-out mutants of the corresponding genes as well as complemented strains were generated and phenotypically characterized. In contrast to A. benhamiae wild type and complemented strains, both mutants failed to produce sexual reproductive structures in mating experiments. Analysis of growth...
  • Idioma: Inglês

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