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A second-generation vaccine protects against the psychoactive effects of cocaine

Carrera, M R ; Ashley, J A ; Wirsching, P ; Koob, G F ; Janda, K D

Proceedings of the National Academy of Sciences of the United States of America, 13 February 2001, Vol.98(4), pp.1988-92 [Periódico revisado por pares]

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  • Título:
    A second-generation vaccine protects against the psychoactive effects of cocaine
  • Autor: Carrera, M R ; Ashley, J A ; Wirsching, P ; Koob, G F ; Janda, K D
  • Assuntos: Cocaine -- Immunology ; Motor Activity -- Physiology
  • É parte de: Proceedings of the National Academy of Sciences of the United States of America, 13 February 2001, Vol.98(4), pp.1988-92
  • Descrição: The effects of immunization with the second-generation cocaine immunoconjugate GND-keyhole limpet hemocyanin (KLH) or with the anti-cocaine mAb GNC92H2 were assessed in a model of acute cocaine-induced locomotor activity. After i.p. administration of cocaine small middle dotHCl (15 mg/kg), rats were tested in photocell cages, and stereotypy was rated to determine preimmunization drug response (baseline). Experimental animals were subjected to an immunization protocol with GND-KLH or treated with the mAb GNC92H2. Rats were then challenged with systemic cocaine, and their locomotor responses were again measured. Active immunization with GND-KLH produced a 76% decrease in the ambulatory measure (crossovers) in the experimental group and a 12% increase in the control group compared with baseline values. Also, stereotypic behavior was significantly suppressed in the vaccinated animals. Decreases in both measures were seen in the experimental group on two subsequent challenges. The maximum effect...
  • Idioma: Inglês

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