skip to main content

Hepatocellular carcinoma in hepatitis D: Does it differ from hepatitis B monoinfection?.(Original Article)(Report)

Abbas, Zaigham ; Qureshi, Mustafa ; Hamid, Saeed ; Jafri, Wasim

Saudi Journal of Gastroenterology, Jan-Feb, 2012, Vol.18(1), p.18 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por
  • Título:
    Hepatocellular carcinoma in hepatitis D: Does it differ from hepatitis B monoinfection?.(Original Article)(Report)
  • Autor: Abbas, Zaigham ; Qureshi, Mustafa ; Hamid, Saeed ; Jafri, Wasim
  • Assuntos: Hepatitis D -- Complications And Side Effects ; Hepatitis D -- Research ; Hepatocellular Carcinoma -- Risk Factors ; Hepatocellular Carcinoma -- Development And Progression ; Hepatocellular Carcinoma -- Research
  • É parte de: Saudi Journal of Gastroenterology, Jan-Feb, 2012, Vol.18(1), p.18
  • Descrição: Background/Aim: Hepatitis D virus (HDV) superinfection in patients with chronic hepatitis B leads to accelerated liver injury, early cirrhosis, and decompensation. It may be speculated that hepatocellular carcinoma (HCC) may differ in these patients from hepatitis B virus (HBV) monoinfection. The aim of this study was to compare clinical aspects of hepatocellular carcinoma in patients of hepatitis D with HBV monoinfection. Patients and Methods: A total of 92 consecutive HCC cases seropositive for antibody against HDV antigen (HDV group) were compared with 92 HBsAg-positive and anti-HDV-negative cases (HBV group). Results: The features including sex, body mass index, presence of ascites, serum biochemistry, gross tumor appearance, child class, barcelona cancer liver clinic and okuda stages were not significantly different between the 2 groups. Decreased liver size was noticed more in cases of HDV compared with HBV group where the liver size was normal or increased ( P =0.000). HDV patients had lower platelets ( P =0.053) and larger varices on endoscopy ( P =0.004). Multifocal tumors and elevated alpha-fetoprotein level >1000 IU/mL were more common in HBV group ( P =0.040 and P = 0.061). TNM classification showed more stage III-IV disease in HBV group ( P =0.000). Conclusion: Decreased liver size and indirect evidence of more severe portal hypertension and earlier TNM stage compared with HBV monoinfection indicate that HDV infection causes HCC in a different way, possibly indirectly by inducing inflammation and cirrhosis.
  • Idioma: English

Buscando em bases de dados remotas. Favor aguardar.