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In vitro stability of arsenic trioxide-liposome encapsulates for acute promyelocytic leukemia treatment

Da Rosa, Francisco Cunha ; Buque Pardinho, Renan ; Schultz Moreira, Mauber Eduardo ; de Souza, Luiz Gustavo Teixeira ; de Moraes Flores, Érico Marlon ; Mortari, Sergio Roberto ; Dressler, Valderi Luiz

Leukemia Research, 01/2019, Vol.76, C, pp.11-14 [Periódico revisado por pares]

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  • Título:
    In vitro stability of arsenic trioxide-liposome encapsulates for acute promyelocytic leukemia treatment
  • Autor: Da Rosa, Francisco Cunha ; Buque Pardinho, Renan ; Schultz Moreira, Mauber Eduardo ; de Souza, Luiz Gustavo Teixeira ; de Moraes Flores, Érico Marlon ; Mortari, Sergio Roberto ; Dressler, Valderi Luiz
  • Assuntos: Arsenic Trioxide ; Liposome ; Arsenic Species
  • É parte de: Leukemia Research, 01/2019, Vol.76, C, pp.11-14
  • Descrição: •Arsenic trioxide-nanoliposome encapsulates were synthesized.•Stability of arsenic trioxide encapsulates with liposome was evaluated.•Stability of As(III) depends on the storing conditions.•Arsenic species were monitored by LC-ICP-MS during 90-days. In this work, we investigated the stability of arsenic trioxide (ATO) used in leukemia treatment, encapsulated with nanoliposome, with the aid of ultrasound treatment. Stability studies of As species were followed by liquid chromatography-inductively coupled plasma mass spectrometry (LC-ICP-MS), allowing for the detection of the conversion of low amounts of As(III) to As(V) or the formation of other As species. The influence of storage temperature and time on ATO was evaluated. Low amounts of As(III) to As(V) conversions were observed when the As encapsulated with nanoliposome was incubated at 25 °C and 40 °C. However, As(III) was stable if the solution was maintained at 5 °C, even after 90 days. No formation of other As species was observed, indicating good stability of the encapsulated ATO. Next step of the work will focus on spray drying of ATO nanoliposomes-encapsuleted with the aim of long term stability of As.
  • Idioma: Inglês

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