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Expression of the cell cycle regulation proteins p53 and p21WAF1 in different types of non-dysplastic leukoplakias

Visioli, Fernanda; Lauxen, Isabel Silva; Sant'Ana Filho, Manoel; Rados, Pantelis Varvaki

Journal of Applied Oral Science; v. 20, n. 3 (2012); 369-375

Universidade de São Paulo. Faculdade de Odontologia de Bauru 2012-06-01

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  • Título:
    Expression of the cell cycle regulation proteins p53 and p21WAF1 in different types of non-dysplastic leukoplakias
  • Autor: Visioli, Fernanda; Lauxen, Isabel Silva; Sant'Ana Filho, Manoel; Rados, Pantelis Varvaki
  • Assuntos: Leukoplakia; Oral Cancer; Tumor Suppressor Protein P53; Cyclin-Cependent Kinase Inhibitor P21
  • É parte de: Journal of Applied Oral Science; v. 20, n. 3 (2012); 369-375
  • Descrição: OBJECTIVES: The aim of this study was to analyze the immunolabeling of two cell cycle protein regulators, p53 and p21WAF1, in non-dysplastic leukoplakias with different epithelial alterations: acanthosis, hyperkeratosis and acanthosis combined with hyperkeratosis, and compare them with dysplastic leukoplakias. MATERIAL AND METHODS: This was a prospective cohort study involving 36 patients with oral homogeneous leukoplakias. excisional biopsies were performed and the patients remain under clinical follow-up. The leukoplakias were divided into four groups: 6 acanthosis, 9 hyperkeratosis, 10 acanthosis combined with hyperkeratosis, and 11 epithelial dysplasias. Paraffin-embebeded sections were immunostained for p53 and p21WAF1. Five hundred cells from the basal layer and 500 from the parabasal layer were counted to determine the percentage of positive cells. A qualitative analysis was also carried out to determine the presence or absence of immunohistochemical staining in the intermediate and superficial layers. Groups were compared with ANOVA (p
  • DOI: 10.1590/S1678-77572012000300013
  • Títulos relacionados: https://www.revistas.usp.br/jaos/article/view/46246/49868
  • Editor: Universidade de São Paulo. Faculdade de Odontologia de Bauru
  • Data de publicação: 2012-06-01
  • Formato: Adobe PDF
  • Idioma: Inglês

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