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Impact of Corticosterone Treatment on Spontaneous Seizure Frequency and Epileptiform Activity in Mice with Chronic Epilepsy

Castro, Olagide W.; Santos, Victor R.; Pun, Raymund Y. K.; Mcklveen, Jessica M.; Batie, Matthew; Holland, Katherine D.; Gardner, Margaret; Garcia-Cairasco, Norberto; Herman, James P.; Danzer, Steve C. Universidade De São Paulo

PLOS ONE, SAN FRANCISCO, v. 7, n. 9, pp. 745-749, SEP 28, 2012

PUBLIC LIBRARY SCIENCE; SAN FRANCISCO 2012

Acesso online

  • Título:
    Impact of Corticosterone Treatment on Spontaneous Seizure Frequency and Epileptiform Activity in Mice with Chronic Epilepsy
  • Autor: Castro, Olagide W.; Santos, Victor R.; Pun, Raymund Y. K.; Mcklveen, Jessica M.; Batie, Matthew; Holland, Katherine D.; Gardner, Margaret; Garcia-Cairasco, Norberto; Herman, James P.; Danzer, Steve C.
  • Universidade De São Paulo
  • Assuntos: Spontaneous Recurrent Seizures; Low-Dose Corticosterone; Temporal-Lobe Epilepsy; Long-Term Potentiation; Central-Nervous-System; Chronic Stress; Mineralocorticoid Receptors; Kindling Epileptogenesis; Glucocorticoid-Receptors; Structural Plasticity; Multidisciplinary Sciences
  • É parte de: PLOS ONE, SAN FRANCISCO, v. 7, n. 9, pp. 745-749, SEP 28, 2012
  • Descrição: Stress is the most commonly reported precipitating factor for seizures in patients with epilepsy. Despite compelling anecdotal evidence for stress-induced seizures, animal models of the phenomena are sparse and possible mechanisms are unclear. Here, we tested the hypothesis that increased levels of the stress-associated hormone corticosterone ( CORT) would increase epileptiform activity and spontaneous seizure frequency in mice rendered epileptic following pilocarpine-induced status epilepticus. We monitored video-EEG activity in pilocarpine-treated mice 24/7 for a period of four or more weeks, during which animals were serially treated with CORT or vehicle. CORT increased the frequency and duration of epileptiform events within the first 24 hours of treatment, and this effect persisted for up to two weeks following termination of CORT injections. Interestingly, vehicle injection produced a transient spike in CORT levels - presumably due to the stress of injection - and a modest but significant increase in epileptiform activity. Neither CORT nor vehicle treatment significantly altered seizure frequency; although a small subset of animals did appear responsive. Taken together, our findings indicate that treatment of epileptic animals with exogenous CORT designed to mimic chronic stress can induce a persistent increase in interictal epileptiform activity.
    Charles L. Shor Foundation for Epilepsy Research
    National Institute of Neurological Disorders and Stroke [R01NS065020, R01NS062806]
    Programa de Excelencia Academica Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (PROEXCAPES)
    Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
    Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
  • DOI: 10.1371/journal.pone.0046044
  • Títulos relacionados: PLOS ONE
  • Editor: PUBLIC LIBRARY SCIENCE; SAN FRANCISCO
  • Data de publicação: 2012
  • Idioma: Inglês

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