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Non-N-methyl-d-aspartate glutamate receptors in the lateral hypothalamus modulate cardiac baroreflex responses in conscious rats

Crestani, Carlos C.; Deolindo, Milena V.; Alves, Fernando H. F.; Resstel, Leonardo B. M.; Correa, Fernando M. A. Universidade De São Paulo

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, v.36, n.11, p.1079-1085, 2009

WILEY-BLACKWELL PUBLISHING, INC 2009

Acesso online

  • Título:
    Non-N-methyl-d-aspartate glutamate receptors in the lateral hypothalamus modulate cardiac baroreflex responses in conscious rats
  • Autor: Crestani, Carlos C.; Deolindo, Milena V.; Alves, Fernando H. F.; Resstel, Leonardo B. M.; Correa, Fernando M. A.
  • Universidade De São Paulo
  • Assuntos: Baroreflex; Blood Pressure; Glutamate Receptors; Glutamatergic Neurotransmission; Heart Rate; Hypothalamus; Unanesthetized Rats; Stria Terminalis; Periaqueductal Gray; Anesthetized Rats; Nmda Receptors; Bed Nucleus; Parasympathetic Component; Cardiovascular-Responses; Hypotensive Response; Arterial Baroreflex; Pharmacology & Pharmacy; Physiology
  • É parte de: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, v.36, n.11, p.1079-1085, 2009
  • Descrição: P>In the present study, we investigated the effects of inhibition of the lateral hypothalamus (LH) neurotransmission with bilateral microinjection of CoCl(2), a non-selective blocker of neurotransmission, on modulation of cardiac baroreflex responses in conscious rats as well as the involvement of LH glutamatergic neurotransmission in this modulation. Reflex bradycardiac and tachycardiac responses to blood pressure increases (following i.v. infusion of phenylephrine) or decreases (following i.v. infusion of sodium nitroprusside) were investigated in conscious male Wistar rats. Responses were evaluated before and after microinjection of 1 nmol/100 nL CoCl(2), 2 nmol/100 nL 1,2,3,4-tetrahydro-6-nitro-2,3-dioxobenzoquinoxaline-7-sulphonamide (NBQX; a selective non-N-methyl-d-aspartate (NMDA) glutamate receptor antagonist) or different doses (2, 4 or 8 nmol/100 nL) of the selective NMDA glutamate receptor antagonist LY235959. Microinjection of CoCl(2) into the LH had no effect on the tachycardiac baroreflex response, but did evoke a decrease in the reflex bradycardia caused by increases in blood pressure. Microinjection of NBQX into the LH had a similar effect on reflex bradycardia as CoCl(2), but had no effect on the tachycardiac response. Microinjection of increasing doses of LY235959 into the LH had no effect on the cardiac baroreflex response. In conclusion, the data suggest that the LH has a tonic facilitatory influence on the parasympathetic component of the baroreflex. The results also indicate that this facilitatory influence is mediated by local LH glutamatergic neurotransmission through non-NMDA glutamatergic receptors.
    FAPESP
    CNPq[870307/1997-5]
    CNPq[306381/2003-6]
    CNPq[505394/2003-0]
    Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP[06/57670-4]
  • DOI: 10.1111/j.1440-1681.2009.05191.x
  • Títulos relacionados: Clinical and Experimental Pharmacology and Physiology
  • Editor: WILEY-BLACKWELL PUBLISHING, INC
  • Data de publicação: 2009
  • Idioma: Inglês

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